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| 1 | Safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in hepatitis C virus/human immunodeficiency virus co-infected patients显示文摘AIM To evaluate the safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in patients with hepatitis C virus(HCV)/human immunodeficiency virus(HIV) co-infection in an urban HIV clinic.METHODS A retrospective cohort study of 40 subjects co-infected with HIV-1 and HCV treated with the fixed-dose combination of ledipasvir and sofosbuvir for 12 wk from 2014 to 2016.All patients included were receiving antiretroviral therapy(ART) with HIV RNA values of 100 copies/m L or fewer regardless of baseline HCV RNA level.The primary end point was a sustained virologic response of HCV at 12 wk(SVR12) after the end of therapy.RESULTS Of the 40 patients enrolled,55% were black,22.5% had been previously treated for HCV,and 25% hadcirrhosis.The patients were on a wide range of ART.Overall,39 patients(97.5%) had a SVR 12 after the end of therapy,including rates of 97.1% in patients with HCV genotype 1 a and 100% in those with HCV genotype 1 b.One patient with HCV genotype 3 a was included and achieved SVR12.Rates of SVR12 were similar regardless of previous treatment or the presence of compensated cirrhosis.Only 1 patient experienced relapse at week 12 following treatment and deep sequencing didn't reveal any resistance associated mutation in the NS5A or NS5B region.Interestingly,7(17.5%) patients who were adherent to ART experienced HIV viral breakthrough which resolved after continuing the same ART regimen.Two(5%) patients experienced HIV-1 virologic rebound due to noncompliance with HIV therapy,which resolved after resuming the same ART regimen.No severe adverse events were observed and no patient discontinued treatment because of adverse events.The most common adverse events included headache(12.5%),fatigue(10%),and diarrhea(2.5%).CONCLUSION This retrospective study demonstrated the high rates of SVR12 of ledipasvir/sofosbuvir on HCV eradication in patients co-infected with HCV and HIV,regardless of HCV baseline levels,HCV treatment history or cirrhosis condition.The oral combination of ledipasvir/sofosbuvir represents a safe and well tolerated HCV treatment option that does not require modification for many of the common HIV ART.Occasional HIV virologic rebound occurred but later resolved without the need to change ART. | Xiaoping He Lynne Hopkins George Everett Willie M Carter Cynthia SchroppDyce Khalid Abusaada Vincent Hsu | 2017 | World Journal of Hepatology2017，9，30： | 2 |
| 2 | Effects of UV- B on the development and ultrastructure of the primary leaf of wheat (Triticum aestivum)显示文摘 | Hopkins L Bond M A Tobin A K | 1996 | J Exp Bot1996，，： | 2 |
| 3 | Total domination subdivision numbers of trees显示文摘 | Haynes T W Henning M A Hopkins L | 2004 | Discrete Mathematics2004，286，： | 1 |
| 4 | The relationship between tenderness,proteolysis,muscle contraction and dissociation of actomyosin显示文摘 | Hopkins D L Thompson J M | 2001 | Meat Sci2001，57，： | 1 |
| 5 | Seed transmission of Acidovorax avenae subsp, c itrulli in cucurbits显示文摘 | Hopkins D L Thompson C M | 2002 | HortScience2002，37，6： | 1 |
| 6 | Mg2+dependence of halothane-induced Ca2+release from the sarcoplasmic reticulum in rat skeletal muscle显示文摘 | Duke A M Hopkins P M Steele D S | 2003 | J Physiology2003，551，2： | 1 |
| 7 | Nitric oxide-mediated cGMP production in the islands of Calleja in the rat显示文摘 | Vente J Hopkins DA Markerink-van Ittersum M | 1998 | Brain Res1998，789，1： | 1 |
| 8 | Polymorphisms of platelet membrane glycoprotein (GP) Ib alpha Kozak sequence determines the surface level of the GP In-IX-V complex and risk fur early myocardial infarction显示文摘 | Afshar-Khargan V Khoshnevis-Asl M Hopkins P | 1998 | Blood1998，92，： | 1 |
| 9 | Chicken interferon gene: cloning, expression, and analysis显示文摘 | Sekellick M J Ferrandion A F Hopkins D A | 1994 | J Interferon Res1994，14，： | 1 |
| 10 | Formation of an aggregate scale in Arctic sea ice显示文摘 | HOPKINS M A FRANKENSEIN S THORNDIKE A S | 2004 | Journal of Geophysical Research2004，109，01032： | 1 |
| 11 | Analysis of mortality after hip fracture data from a 5-year patient cohort显示文摘 | Arnander M Hopkins J Khaleel A | | 0，，04： | 1 |
| 12 | The effects of carbon dioxide pneumoperitoneum on seeding of tumor in port sites in a rat model显示文摘 | Hopkins M P Dulai R M Occhino A | 1999 | Am J Obstet Gynecol1999，181，6： | 1 |
| 13 | Biological and chemical properties of arable soils affected by long-term organic and inorganic fertilizer applications显示文摘 | SIMEK M HOPKINS D W KALCIK J | 1999 | Biology and Fertility of Soils1999，29，： | 1 |
| 14 | Functional difference between manganese and iron superoxide dismutases in Escherichia coli K-12 显示文摘 | Hopkin K A Papazian M A Steinman H M | 1992 | J Biol Chem1992，267，24： | 1 |
| 15 | Regulation of senescence by eukaryotic translation initiation factor 5A: Implications for plant growth and development显示文摘 | Thompson J E Hopkins M T Taylor C | 2004 | Trends in Plant Science2004，9，4： | 1 |
| 16 | Chicken interferon gene: Cloning, expression, and analysis显示文摘 | Sekellick M J Ferrandino A F Hopkins D A | 1994 | Journal of Interferon Research1994，14，： | 1 |
| 17 | Chicken interferon gene:cloning,expression,and analysis显示文摘 | Sekellick M J Ferrandino A F Hopkins D A Marcus P I | 1994 | J Interferon Res1994，14，2： | 1 |
| 18 | Genetic diversity among elite sorghum inbred lines assessed with simple sequence repeats 显示文摘 | SMITH J S C KRESOVICH S HOPKINS M S | 2000 | CROP SIC2000，40，： | 1 |
| 19 | Synovial hemangioma of the knee 显示文摘 | Barakat M J Hirehal K Hopkins J R | 2007 | J Knee Surg2007，20，4： | 1 |
| 20 | Characteristics of Pestalotiopsis associated with hardy ornamental plants in the UK显示文摘 | Hopkins K E McQuilken M P | 1999 | European Journal of Plant Pa- thology1999，106，1： | 1 |
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