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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 4 | Immunogenetic phenotypes in inflammatory bowel disease显示文摘当前接受的 etiopathogenic 假设建议长期的肠的发炎和煽动性的肠疾病(IBD ) 的相关全身的表明特征由于对居民钠的过分好攻击或病理学的有免疫力的回答细菌的成分。预先安排的因素是粘膜免疫者回答或障碍功能的基因 dysregulation,与环境刺激触发的发作。这些因素和他们的相互作用可以也是疾病显型和疾病前进的重要决定因素。免疫的出现基因显型把支持借给不同免疫者处理的危险性基因调整的建议假设,由钠抗原开车,表示了接着在 IBD 影响临床的显型的同样特定的有免疫力的显型病人。 | Maria C Dubinsky Kent Taylor Stephan R Targan Jerome I Rotter | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 5 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 6 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 7 | 新型冠状病毒肺炎及其心血管效应:流行病学研究的系统综述显示文摘少数新型冠状病毒肺炎(新冠肺炎)患者病情严重,其特征是炎症、微血管损伤和凝血障碍,可能导致心肌损伤、静脉血栓栓塞症(venous thromboembolism, VTE)和动脉闭塞事件。有心血管病危险因素或既往有心血管病的个体可能面临更大的风险。目的:评估各种环境(包括社区、疗养院和医院)中,与新冠肺炎疑似或确诊病例相关的既往存在心血管合并症的患病率。研究者还评估了疑似或确诊新冠肺炎患者随后发生心血管并发症和临床事件的性质和发生率。 | Pellicori P Doolub G Wong CM Lee KS Mangion K Ahmad M Berry C Squire I Lambiase PD Lyon A McCon-nachie A Taylor RS Cleland JG 刘青(摘译) 练桂丽(审校) | 2021 | 中华高血压杂志2021，29，5： | 3 |
| 8 | 油气两相流工况下汽车发动机轴承气蚀磨损的模拟试验研究显示文摘采用超声振动原理建立了一台汽车发动机滑动轴承模拟气蚀试验装置。试验研究了空气混入滑动轴承后对其气蚀磨损的影响。通过大量试验研究结果的分析比较 ,发现空气的混入会使滑动轴承的气蚀磨损降低 ,且含气率越高这种影响作用越明显。 | 安琦 Priest M Taylor C M | 2001 | 机械工程学报2001，37，2： | 2 |
| 9 | The patch test for mixed formulation显示文摘 | Zienkiewicz O C Qu S Taylor R L | 1986 | Int J for Numerical Methods in Engineering1986，23，： | 2 |
| 10 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 11 | Modulation of β-lactam resistance in Staphylococcus aureus by catechins and gallates显示文摘 | Paul D Stapleton Saroj Shah James C Anderson Yukihiko Hara Jeremy M.T Hamilton-Miller Peter W Taylor | 2004 | International Journal of Antimicrobial Agents2004，，5： | 2 |
| 12 | Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300 000 women in US SEER cancer registries显示文摘 | Sarah C Darby Paul McGale Carolyn W Taylor Richard Peto | 2005 | Lancet Oncology2005，，： | 2 |
| 13 | The basic he lix loop helix transcription factor HESR1 regulates endothelial cell tube formation 显示文摘 | Henderson A M Wang S J Taylor A C | 2001 | J Biol Chem2001，276，： | 1 |
| 14 | Gold on titania catalysts for the oxidation of carbon monoxide : Control of pH during preparation with various gold contents显示文摘 | MOREAU F BOND G C TAYLOR A O | 2005 | Journal of Catalysis2005，231，1： | 1 |
| 15 | Determination of wood density in standing white spruce using Pilodyn tester显示文摘 | MICKO M M WANG E I C TAYLOR F W | 1982 | The Forestry Chronicle1982，58，4： | 1 |
| 16 | Structural testing of concurrent programs显示文摘 | Taylor R N Levine D L Kelly C D | 1992 | IEEE Trans Softw Eng1992，18，3： | 1 |
| 17 | Effects of pigment-deficient mutants on the accumulation of photosynthetic proteins in maize显示文摘 | Harpster M H Mayfield S P Taylor W C | 1984 | Plant Mol Biol1984，3，： | 1 |
| 18 | Diagnosis of malaria by detection of Plasmodium falciparum HRP - 2 antigen with a rapid dipstick antigen-capture assay显示文摘 | Taylor | 1994 | Lancet1994，343，： | 1 |
| 19 | Finite element modeling of blood flow in arteries 显示文摘 | Thomas J R Hughes Zarins C K | 1998 | Computer Methods in Applied Mechanics and Engineering1998，158，： | 1 |
| 20 | Chlorination byproducts in chlorinated cooling water of some European coastal power stations 显示文摘 | JENNER H A TAYLOR C J L DONK V | 1997 | Mar Environ Res1997，43，4： | 1 |
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