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| 1 | 持续性姿势-感知性头晕(PPPD)诊断标准:Bárány学会前庭疾病分类委员会共识显示文摘本文提出被纳入前庭疾病国际分类(International Classification of Vestibular Disorders,ICVD)的持续性姿势-感知性头晕(PPPD)的诊断标准。PPPD虽然是一个新的医学术语,但该病的存在由来已久。前庭疾病分类委员会深入汇总、分析了近30年来恐惧性姿势性眩晕(Phobic Postural Vertigo,PPV)、空间运动不适(Space℃Motion Discomfort,SMD)、视觉性眩晕(Visual Vertigo,VV)和慢性主观性头晕(Chronic Subjective Dizziness,CSD)相关的研究,在此基础上提出了PPPD的诊断标准。临床上,头晕、不稳、非旋转性眩晕为PPPD的3个核心症状。PPPD患者常表现为这3个核心症状中的一个或多个,症状持续时间超过3个月,并且在直立姿势、主动/被动运动、暴露于移动视觉刺激或复杂视觉环境中时症状出现加重。PPPD可能与影响平衡系统或引起眩晕、不稳及头晕的疾病所触发有关,包括周围或中枢前庭病变、其他内科疾病或心理疾病。临床上,PPPD既可单独存在,也可与其他临床疾病共病。PPPD可能的亚型分类尚需进一步识别和验证。迄今为止,PPPD确切的病理生理机制尚不明确。新近研究表明,PPPD可能与躯体姿势控制、多感觉信息处理、威胁评估系统与空间定向系统皮质整合的功能异常相关。因此,PPPD被归类为慢性功能性前庭疾病,并不是结构性前庭疾病或精神心理性前庭疾病。 | 李康之(译) 刘博(译) 顾平(审校) 杨旭(审校) Jeffrey PStaab Annegret Eckhardt-Henn Arata Horii Rolf Jacob Michael Strupp Thomas Brandt Adolfo Bronstein | 2020 | 神经损伤与功能重建2020，15，2： | 20 |
| 2 | Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism显示文摘植物 metabolomics 作为一个强大的工具发展了检验基因功能并且获得更深的卓见进植物房间的生理学。在这研究,我们屏蔽了 Arabidopsis 线 overexpressing 米饭全身(FL ) 用煤气的 chromatographytime-of-flight 团 spectrometry (GCTOF/MS ) 的 cDNAs (米饭狐狸 Arabidopsis 线) 基于技术识别引起了新陈代谢的变化的米饭基因。这个屏蔽系统允许显示出改变的代谢物侧面的候选人线的快、可靠的鉴定。我们执行了怀有 Arabidopsis 的侧面的机关边界(高球) 领域(LBD )/Asymmetric 象 Leaves2 一样(ASL ) 基因的米饭 ortholog 的 FL cDNA 的一根米饭狐狸 Arabidopsis 线的 metabolomic 和 transcriptomic 分析, At-LBD37/ASL39。调查米饭狐狸 Arabidopsis 线在与氮新陈代谢有关的代谢物的层次显示出突出的变化。象从 Arabidopsis At-LBD37/ASL39-overexpressor 植物的代谢物分析的结果一样的 transcriptomic 数据与这些调查结果一致。而且, Os-LBD37/ASL39-overexpressing 米饭植物的 metabolomic 和 transcriptomic 分析显示 Os-LBD37/ASL39 在米饭与与氮新陈代谢有关的过程被联系。因此,一个基于 metabolomics 的屏蔽方法的联合和一条 gain-of-function 途径为在 Arabidopsis 和米饭的新奇基因的快速的描述是有用的。 | Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko Horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki Saito | 2010 | Molecular Plant2010，3，1： | 15 |
| 3 | Genome engineering using the CRISPR/Cas system显示文摘Recently, an epoch-making genome engineering technology using clustered regularly at interspaced short palindromic repeats(CRISPR) and CRISPR associated(Cas) nucleases, was developed. Previous technologies for genome manipulation require the time-consuming design and construction of genome-engineered nucleases for each target and have, therefore, not been widely used in mouse research where standard techniques based on homologous recombination are commonly used. The CRISPR/Cas system only requires the design of sequences complementary to a target locus, making this technology fast and straightforward. In addition, CRISPR/Cas can be used to generate mice carrying mutations in multiple genes in a single step, an achievement not possible using other methods. Here, we review the uses of this technology in genetic analysis and manipulation, including achievements made possible to date and the prospects for future therapeutic applications. | Takuro Horii Izuho Hatada | 2014 | World Journal of Medical Genetics2014，4，3： | 9 |
| 4 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 5 | Screening of functionalized self-assembling peptide nanofiber scaffolds with angiogenic activity for endothelial cell growth | Akihiro HORII | 2011 | Progress in Natural Science:Materials International2011，21，2： | 6 |
| 6 | CO_2 insufflation for potentially diffi cult colonoscopies: Effi cacy when used by less experienced colonoscopists显示文摘AIM: To clarify the effectiveness of CO2 insufflation in potentially difficult colonoscopy cases, particularly in relation to the experience level of colonoscopists.METHODS: One hundred twenty potentially difficult cases were included in this study, which involved females with a low body mass index and patients with earlier abdominal and/or pelvic open surgery or previously diagnosed left-side colon diverticulosis. Patients receiving colonoscopy examinations without sedation using a pediatric variable-stiffness colonoscope were divided into two groups based on either CO2 or standard air insufflation. Both insufflation procedures were also evaluated according to the experience level of the respective colonoscopists who were divided into an experienced colonoscopist (EC) group and a less experienced colonoscopist (LEC) group. Study measurements included a 100-mm visual analogue scale (VAS) for patient pain during and after colonoscopyexaminations, in addition to insertion to the cecum and withdrawal times.RESULTS: Examination times did not differ, however, VAS scores in the CO2 group were signifi cantly better than in the air group (P < 0.001, two-way ANOVA) from immediately after the procedure and up to 2 h later. There were no significant differences between either insufflation method in the EC group (P = 0.29), however, VAS scores for CO2 insufflation were significantly better than air insufflation in the LEC group (P = 0.023) immediately after colonoscopies and up to 4 h afterwards.CONCLUSION: CO2 insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs. | Toshio Uraoka Jun Kato Motoaki Kuriyama Keisuke Hori Shin Ishikawa Keita Harada Koji Takemoto Sakiko Hiraoka Hideyuki Fujita Joichiro Horii Yutaka Saito Kazuhide Yamamoto | 2009 | World Journal of Gastroenterology2009，15，41： | 5 |
| 7 | 固相萃取/气相色谱质谱法测定灰尘中的氯代多环芳烃显示文摘建立了固相萃取(SPE)/气相色谱质谱(GC/MS)联用检测灰尘中氯代多环芳烃(ClPAHs)的方法.以正己烷和二氯甲烷混合液为提取溶剂,索氏提取灰尘样品中的20种ClPAHs,活性硅胶层析柱与活性炭混合硅胶SPE柱协同净化.净化后的提取液采用GC/MS测定,SIM模式扫描,并用质谱特征离子定量分析.结果表明,填充量为0.2 g(W(活性炭)∶W(硅胶)=1∶40)的活性炭混合硅胶SPE小柱能有效地将ClPAHs分离出来,载样后采用反向溶剂洗脱,既提高了回收率又减少了洗脱剂甲苯的用量,净化效果好.处理灰尘样品后检测分析,20种ClPAHs的平均回收率稳定在60.4%—120.1%,相关系数>0.99,检出限为0.04—0.17 ng.g-1,相对标准偏差为1.6%—10.2%.本方法前处理简单,定性、定量准确可靠,可广泛应用于环境介质中氯代多环芳烃的检测. | 郑继三 马静 Yuichi Horii Kurunthachalam Kannan Takeshi Ohura 徐刚 吴明红 | 2012 | 环境化学2012，31，7： | 4 |
| 8 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 9 | Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole显示文摘AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，15： | 3 |
| 10 | Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers显示文摘AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，13： | 2 |
| 11 | Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers显示文摘 | Shinichi Fukushige Akira Horii | 2012 | Cancer Letters2012，，： | 2 |
| 12 | Shearing strength of steel fiber reinforced concrete显示文摘 | KOHNO K HORII K YUKITOMO K GOTOH Y | 1983 | Transactions of the Japan Concrete Institute1983，5，4： | 2 |
| 13 | An Asian emission inventory of anthropogenic emission sources for the period 1980–2020显示文摘 | Ohara T. Akimoto H. Kurokawa J. Horii N. Yamaji K. Yan X. Hayasaka T | 2007 | Atmospheric Chemistry and Physics2007，，100： | 2 |
| 14 | NOx reduction mechanism of a methane-air smithells flame显示文摘 | Nishioka M Ishigami Y Horii H | 2006 | Combustion and Flame2006，147，12： | 1 |
| 15 | Chlorinated and parent polycyclic aromatic hydrocarbons in environmental samples from an electronic waste recycling facility and a chemical industrial complex in China 显示文摘 | Ma J Horii Y Cheng J | 2009 | Environ Sei Teehnol2009，43，3： | 1 |
| 16 | Endolymphatic hy- drops in Meniere's disease detected by MRI after in- tratympanic administration of gadolinium: comparison with sudden deafness显示文摘 | Horii A Osaki Y Kitahara T | 2011 | Acta Oto Laryngologica2011，131，6： | 1 |
| 17 | Thermal stability of the spi ronaphthoxazine colored form in polymericsiloxanes显示文摘 | Nakao R Noda F Horii T | | 0，，02： | 1 |
| 18 | Risk factors for nontraumatic osteonecrosis of the femoral head after renal transp lantation显示文摘 | Inoue S Horii M Asano T | 2003 | J Orthop Sci2003，8，6： | 1 |
| 19 | Analytical model for fracture behaviors of pseudo strain-hardening cementitious composites 显示文摘 | Kabele P Horii H | 1996 | Journal :f Materials Concrete Structures and Pavements (Proceedings of JSCE)1996，532，30： | 1 |
| 20 | Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation 显示文摘 | Horii M Uemura S Uemura M | 2008 | Heart Vessels2008，23，5： | 1 |
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