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6篇 您的检索式：作者名="Hostomsky"

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		题名	作者	年代	出处	被引量
	1	Crystallization kinetics of amorphous alumina–zirconia–silica ceramics显示文摘	T. Chráska J. Hostomsky M. Klementová J. Dubsky	2009	Journal of the European Ceramic Society2009，，15：	1
	2	Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis 显示文摘	Hostomsky Z Hostomska Z Fu TB	1992	J Virol1992，66，：	1
	3	Design,synthesis,and evaluation of 3,4-dihydro-2H-diazepino indol-1-ones as inhibitors of poly(ADP-ribose)polymerase显示文摘	TIKHE J G WEBBER S E HOSTOMSKY Z	2004	J Med Chem2004，47，22：	1
	4	Design, syn- thesis, and evaluation of 3,4-dihydro-2H- diazepino indol-l-ones as inhibitors of poly(ADP-ribose) polymerase 显示文摘	TIKHE JG WEBBER SE HOSTOMSKY Z	2004	JMed Chem2004，47，22：	1
	5	Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase显示文摘	DAVIES J F HOSTOMSKA Z HOSTOMSKY Z	1991	Science1991，252，5002：	1
	6	Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line显示文摘Evaluating the effects of novel drugs on appropriate tumor models has become crucial for developing more effective therapies that target highly tumorigenic and drug-resistant cancer stem cell(CSC)populations.In this study,we demonstrate that a subset of cancer cells with CSC properties may be enriched into tumor spheroids under stem cell conditions from a non-small cell lung cancer cell line.Treating these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK1 inhibitor PF-00477736 revealed that PF-00477736 enhances the anti-proliferative effect of gemcitabine against both the parental and the CSC-like cell populations.However,the CSC-like cells exhibited resistance to gemcitabine-induced apoptosis.Collectively,the spheroid-forming CSC-like cells may serve as a model system for understanding the mechanism underlying the drug resistance of CSCs and for guiding the development of better therapies that can inhibit tumor growth and eradicate CSCs.	Douglas D.Fang Joan Cao Jitesh P.Jani Konstantinos Tsaparikos Alessandra Blasina Jill Kornmann Maruja E.Lira Jianying Wang Zuzana Jirout Justin Bingham Zhou Zhu Yin Gu Gerrit Los Zdenek Hostomsky Todd VanArsdale	2013	Frontiers of Medicine2013，7，4：	0

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