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| 1 | Neuroprotective effects of rutaecarpine on cerebral ischemia reperfusion injury显示文摘Rutaecarpine,an active component of the traditional Chinese medicine Tetradium ruticarpum,has been shown to improve myocardial ischemia reperfusion injury.Because both cardiovascular and cerebrovascular diseases are forms of ischemic vascular disease,they are closely related.We hypothesized that rutaecarpine also has neuroprotective effects on cerebral ischemia reperfusion injury.A cerebral ischemia reperfusion model was established after 84,252 and 504 μg/kg rutaecarpine were given to mice via intraperitoneal injection,daily for 7 days.Results of the step through test,2,3,5-triphenyl tetrazolium chloride dyeing and oxidative stress indicators showed that rutaecarpine could improve learning and memory ability,neurological symptoms and reduce infarction volume and cerebral water content in mice with cerebral ischemia reperfusion injury.Rutaecarpine could significantly decrease the malondialdehyde content and increase the activities of superoxide dismutase and glutathione peroxidase in mouse brain.Therefore,rutaecarpine could improve neurological function following injury induced by cerebral ischemia reperfusion,and the mechanism of this improvement may be associated with oxidative stress.These results verify that rutaecarpine has neuroprotective effects on cerebral ischemia reperfusion in mice. | Chunlin Yan Ji Zhang Shu Wang Guiping Xue Yong Hou | 2013 | Neural Regeneration Research2013，8，22： | 20 |
| 2 | Disordered Translocation is Hastening Local Extinction of the Chinese Giant Salamander显示文摘Biodiversity is declining globally by an unprecedented extinction rate.This is especially true for amphibians,accounting for 24.3%of all threatened vertebrates.As the largest extant amphibian species in the world,wild populations of the Chinese giant salamander(Genus Andrias)(CGS)have decreased dramatically because of overexploitation and habitat degradation.Translocation has become an important strategy for restoring threatened wild populations worldwide.However,disordered tra nsloca tion usually has negative effects on the native populations.We provide an overview of CGS translocation and show that disordered translocation can increase local population extinction.Nearly four times the estimated number of wild individuals have been released across China.There a re three types of translocation used for CGS,namely,reinforcement,reintroduction and ecological replacement,the last of which accounts for over one-third of translocations.Our genetic screening revealed that most released individuals were not from local populations,with one to four lineages detected in every release site(n=6).This disordered translocation can potentially reduce the genetic integrity of original populations.Hence,we suggest suspending current CGS translocation activities immediately,until more robust measures can be developed and implemented to improve the current translocation program,especially with respect to lineage identifica tion a nd the identifica tion of appropriate release sites. | Guocheng SHU Ping LIU Tian ZHAO Cheng LI Yinmeng HOU Chunlin ZHAO Jie WANG Xiaoxiao SHU Jiang CHANG Jianping JIANG Feng XIE | 2021 | Asian Herpetological Research2021，12，3： | 4 |
| 3 | Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice显示文摘Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol(0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice. | Ji Zhang Chunlin Yan Shu Wang Yong Hou Guiping Xue Li Zhang | 2014 | Neural Regeneration Research2014，9，9： | 4 |
| 4 | Comparision of biodegradable and medtallic tension-band fixation for patella fractures 显示文摘 | Chen Aimin Hou Chunlin Bao Juliang | 1998 | J Acta Orthop Scand1998，69，1： | 1 |
| 5 | Comparision of biodegradable and medtallic tension-band fixation for patella fractures显示文摘 | Chen Aimin Hou Chunlin Bao Juliang | 1998 | J Acta Orthop Scand1998，69，1： | 1 |
| 6 | Treatment of Ischial Pressure Sores Using a Modified Gracilis Myofasciocutaneous Flap显示文摘 | Haodong Lin Chunlin Hou Aimin Chen Zhen Xu | 2010 | J reconstr Microsurg2010，，03： | 1 |
| 7 | Chitin bridging of peripheral nerve defects:an experimental study and report of four eases 显示文摘 | Gou Sanhuai Hou ChunLin Wang Dongrong | 1996 | Chinese Journal Orthopaedics1996，16，3： | 1 |
| 8 | Comparision of biodegradable and medtallic tension-band fixation for patella fractures 显示文摘 | Chen Aimin Hou Chunlin Bao Juliang | 1998 | J Acta Orthop Scand1998，69，1： | 1 |
| 9 | Reconstructed bladder innervation below the level of spinal cord injury:the knee-tendon to bladder artificial reflex arc显示文摘 | Zheng Xianyou Hou Chunlin Zhong Hongbin | | 0，，01： | 1 |
| 10 | Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment显示文摘Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of wound status and complications,including wound re-tearing,inflammation,and morphology,are key focal points for comprehensive healthcare.Herein,an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive(DLGel)by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains.The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue,providing a basis for reliable wound closure.DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion,excellent hemostatic performance,outstanding antimicrobial properties,and self-repair capability.Furthermore,a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies.This strategy translates biological information into visual graphics,providing real-time early warning and assessment of postoperative wound-abnormality/-morphology,such as laceration,inflammation,and necrosis.Therefore,DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure,wound healing,and real-time postoperative wound-status warning and assessment within the unobservable and undetectable“black box”regions in a context of non-clinical comprehensive therapy. | Ouyang Yue Xuechuan Wang Mengdi Hou Siwei Sun Manhui Zheng Xiaoliang Zou Zhongxue Bai Chunlin Liu Xinhua Liu | 2024 | Nano Research2024，17，5： | 0 |
| 11 | Some contributions to world microsurgery by Chinese scholars显示文摘Dr.Chen Zhongwei started the era of microsurgery with the world very first limb replantation in 1963.Over half a century,generations of Chinese surgical experts in microsurgery have innovatively made great contributions in the development of microsurgery in the world.The microsurgery in China has always been kept at the leading edge and advanced academic status in the world.The microsurgical experts in China have achieved and made great contributions in the fields of replantation surgery,reconstructive surgery,soft-tissue repair,and studies in repair of peripheral nerve.This article describes in details of the great achievements and contributions made to the world microsurgery by the Chinese surgeons.Look back into the past,the development of microsurgery in China embodies great efforts and wisdom of the earlier generations.Looking into the future,the younger generations should inherit the course of the older gen erations and continue to promote the popularisation and development of microsurgery in China. | Hou Chunlin | 2020 | 中华显微外科杂志2020，43，3： | 0 |
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