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| 1 | 677TT genotype is associated with elevated risk of methotrexate (MTX) toxicity in juvenile idiopathic arthritis: treatment outcome, erythrocyte con- centrations of MTX and folates, and MTHFR polymorphisms显示文摘 | TUKOYA J CHLADEK J HROCH M | 2010 | J Rheumatol2010，37，10： | 1 |
| 2 | Early and delayed cardioproteetive intervention with dexrazoxane each show different potential for prevention of chronic anthracycline eardiotoxieity in rabbits显示文摘 | Jirkovsky E Lencova-Popelova O Hroch M | 2013 | Toxicology2013，311，3： | 1 |
| 3 | Chronic anthracycline cardiotoxicity:molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways显示文摘 | Jirkovsky E PopelováO Kriváková-StankováP VávrováA Hroch M HaskováP | 2012 | J Pharmacol Exp Ther2012，343，2： | 1 |
| 4 | The occurrence of localized shear bands at non-isothermal hot-forging of Ti alloys显示文摘 | LUKAC I PETRIK J KOKARDA V HROCH P | 1988 | Kovove Materialy-Metallic Materials1988，26，2： | 1 |
| 5 | Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic an-thracycline cardiotoxicity in rabbits显示文摘 | Jirkovsky E Lencová-Popelová O Hroch M | | 0，，03： | 1 |
| 6 | 677TT genotype is associated with elevated risk of methotrexate (MTX) toxicity in juvenile idiopathic arthritis: treatment outcome, erythrocyte concentrations of MTX and folates,and MTHFR polymorphisms 显示文摘 | Tukoya J Cjladek J Hroch M | 2010 | Rheumatol2010，37，10： | 1 |
| 7 | The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats显示文摘 | Kucera O Garnol T Lotková H Stanková P Mazurová Y Hroch M Bolehovská R Rousar T Cervinková Z | 2011 | Physiological Research2011，，2： | 1 |
| 8 | 677TT genotype is associated with elevated risk of methotrexate (MTX) toxic-ity in juvenile idiopathic arthritis treatment outcome,eryth-rocyte concentrations of MTX and folates,and MTHFR polymorphisms显示文摘 | Tukova J Chladek J Hroch M | 2010 | J Rheumatol2010，37，10： | 1 |
| 9 | Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats显示文摘AIM To investigate the effect of resveratrol on biliary secretion of cholephilic compounds in healthy and bile duct-obstructed rats. METHODS Resveratrol(RSV) or saline were administered to rats by daily oral gavage for 28 d after sham operation or reversible bile duct obstruction(BDO). Bile was collected 24 h after the last gavage during an intravenous bolus dose of the Mdr1/Mrp2 substrate azithromycin. Bile acids,glutathione and azithromycin were measured in bile to quantify their level of biliary secretion. Liver expression of enzymes and transporters relevant for bile production and biliary secretion of major bile constituents and drugs were analyzed at the m RNA and protein levels using q RT-PCR and Western blot analysis,respectively. The TR-FRET PXR Competitive Binding Assay kit was used to determine the agonism of RSV at the pregnane X receptor. RESULTS RSV increased bile flow in sham-operated rats due to increased biliary secretion of bile acids(BA) and glutathione. This effect was accompanied by the induction of the hepatic rate-limiting transporters for bile acids and glutathione,Bsep and Mrp2,respectively. RSV also induced Cyp7 a1,an enzyme that is crucial for bile acid synthesis; Mrp4,a transporter important for BA secretion from hepatocytes to blood; and Mdr1,the major apical transporter for xenobiotics. The findings were supported by increased biliary secretion of azithromycin. The TR-FRET PXR competitive binding assay confirmed RSV as a weak agonist of the human nuclear receptor PXR,which is a transcriptional regulator of Mdr1/Mrp2. RSV demonstrated significant hepatoprotective properties against BDO-induced cirrhosis. RSV also reduced bile flow in BDO rats without any corresponding change in the levels of the transporters and enzymes involved in RSV-mediated hepatoprotection. CONCLUSION Resveratrol administration for 28 d has a distinct effect on bile flow and biliary secretion of cholephilic compounds in healthy and bile duct-obstructed rats. | Eva Dolezelova Alena Prasnicka Jolana Cermanova Alejandro Carazo Lucie Hyrsova Milos Hroch Jaroslav Mokry Michaela Adamcova Alena Mrkvicova Petr Pavek Stanislav Micuda | 2017 | World Journal of Gastroenterology2017，23，43： | 0 |
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