|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance显示文摘前列腺癌症(PCa ) 是在在世界上的人之中的第二很普通的恶意。阉割抵抗的前列腺癌症(CRPC ) 是疾病的致命的形式,它在抵抗之上发展首先衬里雄激素剥夺治疗(ADT ) 。新兴的证据为在 CRPC 的发展和维护表明轴的 PI3K-AKT-mTOR 表明一个关键角色。这条小径,是在先进 PCas 的多数的 deregulated,与象蛋白质合成,增长,幸存,新陈代谢和区别那样的下游地细胞的过程为生长信号的集成用作批评连结,因此提供机制让癌症细胞克服压力与雄激素剥夺联系了。而且,现出症状之前的潜的研究阐明了在发信号的 PI3K-AKT-mTOR 和雄激素受体(AR ) 之间的一个直接连接削减,在 ADT 抵抗的发展期间揭示在这些小径之间的动态相互影响。因此,为 PI3K 小径的很多个新奇禁止者的继续的临床的发展有一个清楚的基本原理,它提供堵住 CRPC 生长和幸存的潜力。在这评论,我们将在 PCa 前进和阉割抵抗探索 PI3K-AKT-mTOR 小径的关联以便在先进 PCa 通知临床的发展特定的小径禁止者。另外,我们将在我们的临床的知识加亮当前的缺乏,最尤其是对能精确地为对 PI3K 小径禁止者的反应预言的 biomarkers 的需要。 | Merritt P Edlind Andrew C Hsieh | 2014 | Asian Journal of Andrology2014，16，3： | 20 |
| 2 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 3 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 4 | Potential of utilizing jellyfish as food in Western countries 显示文摘 | Hsieh Y-H P Rudloe J | 1994 | Trends Food Sci Tech1994，5，： | 1 |
| 5 | Bioretention column studies of phosphorus removal from urban storm water runoff显示文摘 | Hsieh C H Davis A P Needleman B A | 2007 | Water Environ Res2007，79，2： | 1 |
| 6 | Molecular mechanisms of DNA mismatch repair显示文摘 | Hsieh P | 2001 | Mutat Res2001，486，2： | 1 |
| 7 | DNA mismatch repair:molecular mec-hanisms and biological function显示文摘 | Schofield MJ Hsieh P | 2003 | Annu Rev Microbiol2003，57，： | 1 |
| 8 | Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells显示文摘 | Hsieh FH Sharma P Gibbons A | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 9 | Improved foreign gene expression in plants using a virus-encoded suppressor of RNA silencing modified to be developmentally harmless显示文摘 | Saxena P Hsieh Y C Alvarado V Y | 2011 | Plant BiotechnolJ2011，9，6： | 1 |
| 10 | Novel high step-up DC-DC converter with coupled-inductor and switched-capacitor techniques for a sustainable energy system显示文摘 | Hsieh Y P Chen J F Liang T J | 2011 | IEEE Transactions on Power Electronics2011，26，12： | 1 |
| 11 | Analysis of sulfides in the presence of ferric minerals by diffusion methods显示文摘 | Hsieh Y P Chung S W Tsau Y J | 2002 | Chemical Geology2002，182，24： | 1 |
| 12 | Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials显示文摘 | Hsieh TC Burfeind P Laud K | 1999 | Int J Oncol1999，15，2： | 1 |
| 13 | Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways 显示文摘 | Chen P N Hsieh Y S Chiou H L | 2005 | Chem Biol Interact2005，156，： | 1 |
| 14 | Jellyfish as food显示文摘 | Hsieh Y-H P Leong F M Rudloe | 2001 | Hydrobiologia2001，451，： | 1 |
| 15 | Ultrasound assessment of cervical length in pregnancy 显示文摘 | Chao A S Chao A Hsieh P C | 2008 | Taiwan J Obstet Gynecol2008，47，3： | 1 |
| 16 | Characteristics of ground surface settlement during excavation 显示文摘 | Ou C Y Hsieh P G Chiou D C | 1993 | Canadian Geotechnical Journal1993，30，5： | 1 |
| 17 | Structural Effect on UV Emission Properties of High-Quality ZnO Thin Films Deposited by RF Magnetron Sputtering显示文摘 | Hsieh P T Chen Y C Kao K S | 2007 | Physica B:Condensed Matter2007，392，12： | 1 |
| 18 | Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent显示文摘 | HSIEH P K CHANG S C HUANG C C | 2005 | J Virol2005，79，13： | 1 |
| 19 | Deterministic inventory model for deteriorating items with capacity constraint and time-proportional backlogging rate显示文摘 | Dye C Y Ouyang L Y Hsieh T P | 2007 | European Journal of Operational Research2007，178，3： | 1 |
| 20 | Mg based nano-composites fabricated by friction stir processing 显示文摘 | Lee C J Huang J C Hsieh P J | 2006 | Scripta Materialia2006，54，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员