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| 1 | Study of Helicity in Typhoon Rainfall Regions——A Case Study of Typhoon 'Muifa'显示文摘Using the center of figure method and center of mass method,precipitation and heavy precipitation processes caused by No.9 typhoon 'Muifa' in 2011 were analyzed based on helicity,and the mechanism of typhoon rainfall was interpreted from the relation between helicity and energy. The results showed that horizontal helicity checked the diffusion of nonlinear energy and maintained the development of the system. Precipitation mainly appeared on the southeast of vertical helicity,while heavy precipitation mainly occurred on its southwest. Compared with the center of figure method,the center of mass method had good results,especially for heavy precipitation. Vertical helicity at 700 hPa reflected system deviation in rainfall regions well and had the best correction effect on rainfall intensity and | Huang Weiqi Wang Ju Huang Hong Hu Banghui | 2016 | Meteorological and Environmental Research2016，7，1： | 1 |
| 2 | Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy显示文摘Inflammatory bowel disease(IBD)is a chronic and relapsing disorder for many people associated with poor health.Although there are some clinical drugs for IBD treatment,the development of effective therapeutics on IBD patients has always been necessary.Here,we show that externalized phosphatidylserine(PS)is observed on the surface of colonic capillaries.Annexin A5(ANXA5)with high affinity for PS has a good targeting to the colon and effectively alleviates experimental colitis.In contrast,ANXA5 mutant(A5m)lacking the PS-binding ability,has no accumulation in the colon and no therapeutic effects on colitis.Mechanistic investigations indicate that ANXA5 reduces the inflammatory cell infiltration by inhibiting endothelial cell activation dependent on PS-binding ability.With the increasing of PS exposure on activated HUVECs(human umbilical vein endothelial cells),ANXA5 binding induces the internalization of TLR4 via PS-dependent endocytosis.We provide new insights on the molecular mechanism of ANXA5 for its anti-inflammatory effect.Our data suggest that PS-externalization is a potential target of ANXA5 aiming at targeted drug delivery(TDD)for IBD treatment. | Xuerui Zhang Lulu Song Lin Li Banghui Zhu Lina Huo Zhaoqing Hu Xinran Wang Jie Wang Mengyue Gao Jing Zhang Zichun Hua | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 3 | Analysis of Characteristic and Causes of a Strong Cooling Process in China in the Early Winter of 2020/2021显示文摘The characteristics and causes of a drop in temperature during a cold wave process in the early winter of 2020/2021 were analyzed.The results show that the air temperature at 700-600 hPa over China was firstly and mostly influenced by the cold wave process,and then the cold air gradually extended to the lower layer,causing the most severe cooling in North China and its nearby areas.During the cold wave,the longitude of the upper-level jet over the Chinese mainland was larger;the Ural blocking high and the East Asian trough were stronger,so that the geopotential height gradient between the two was also significantly larger;the meridional air flow was abnormally strong,which was conducive to the southward transport of cold air from the middle and high latitudes.Results of the diagnostic analysis further show that the outbreak of the cold wave and the negative temperature tendency anomaly in the key area were mainly caused by the meridional temperature horizontal advection anomaly,while the temperature rise accompanied by abnormal air subsidence compensated for the abnormal decrease in temperature,which was conducive to the gradual rise of temperature in the key area. | Ju WANG Tianju WANG Hong HUANG Banghui HU Xuezhong WANG | 2023 | Meteorological and Environmental Research2023，14，1： | 0 |
| 4 | Error Inhomogeneity in the Computation of Spherical Mean Displacement显示文摘The traditional method for computing the mean displacement in latitude–longitude coordinates is a spherical meridional–zonal resultant displacement method(MRDM), which regards the displacement as the resultant vector of the meridional and zonal displacement components. However, there are inhomogeneity and singularity in the computation error of the MRDM, especially at high latitudes. Using the NCEP/NCAR long-term monthly mean wind and idealized wind fields, the inhomogeneity in the MRDM was accessed by using a great circle displacement computing method(GCDM) for non-iterative cases. The MRDM and GCDM were also compared for iteration cases by taking the trajectories from a three-time level reference method as the real trajectories. In the horizontal direction, the GCDM assumes that an air particle moves along its locating great circle and that the magnitude of the displacement equals the arc length of the great circle. The inhomogeneity of the MRDM is evaluated in terms of the horizontal distance error from the products of wind speed, lapse time, and angle difference from the GCDM displacement orient.The non-iterative results show that the mean horizontal displacement computed through the MRDM has both computational and analytical errors. The displacement error of the MRDM depends on the wind speed, wind direction, and the departure latitude of the air particle. It increases with the wind speed and the departure latitude. The displacement magnitude error has a four-wave pattern and the displacement direction error has a two-wave feature in the definition range of the wind direction. The iterative result shows that the displacement magnitude error and angle error of the MRDM and GCDM with respect to the reference method increase with the lapse time and have similar distribution patterns. The mean magnitude error and the angle error of the MRDM are nearly twice as large as those of the GCDM. | Xuezhong WANG Banghui HU Hong HUANG Ju WANG Gang ZENG Yanke TAN Li ZOU | 2017 | Journal of Meteorological Research2017，31，6： | 0 |
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