6篇
您的检索式：作者名="Hu Jinxian"
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| 1 | Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy显示文摘Immunotherapy is emerging as a powerful tool for combating many human diseases.However,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly restricted.The major obstacle is the lack of effective technologies for transporting therapeutic agents across the blood-brain barrier(BBB)and achieving targeted delivery to specific cells once across the BBB.Ferritin,an iron storage protein,traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1(TfR1)overexpressed on BBB endothelial cells.Here,we developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse model.We fused different glioma-targeting moieties on self-assembled ferritin nanoparticles via genetic engineering,and RGE fusion protein nanoparticles(RGE-HFn NPs)were identified as the best candidate.Furthermore,RGE-HFn NPs encapsulating a stimulator of interferon genes(STING)agonist(SR717@RGE-HFn NPs)maintained stable self-assembled structure and targeting properties even after traversing the BBB.In the glioma-bearing mouse model,SR717@RGE-HFn NPs elicited a potent local innate immune response in the tumor microenvironment,resulting in significant tumor growth inhibition and prolonged survival.Overall,this biomimetic brain delivery platform offers new opportunities to overcome the BBB and provides a promising approach for brain drug delivery and immunotherapy in patients with glioma. | Bin Wang Maoping Tang Ziwei Yuan Zhongyu Li Bin Hu Xin Bai Jinxian Chu Xiaoyang Xu Xue-Qing Zhang | 2022 | Bioactive Materials2022，7，10： | 2 |
| 2 | Lanthanum Ox- ides-lmproved Catalytic Performanee of ZSM-5 in Toluene Alkyla- tion with Methanol 显示文摘 | Zhang Lidong Gao Junhua Hu Jinxian | 2009 | Catalysis Letters2009，130，： | 1 |
| 3 | Lanthanum oxides-improved catalytic performance of ZSM-5 in toluene alkylation with methanol 显示文摘 | Zhang Lidong Gao Junhua Hu Jinxian | 2009 | Catalysis Letters2009，130，34： | 1 |
| 4 | Synthesis of bis (substituted benzylidene) cycloalkanones from aldehydes and ketals under microwave irradiation显示文摘 | Wang Jinxian Kang Liqin HU Yulai | 2002 | J Chem Research(S)2002，，3： | 1 |
| 5 | The research of Gecko ecology and biology characteristic显示文摘 | Yu jinxian Hu tingsong | | The studies for medicinal purposes animal0，12，2： | 1 |
| 6 | Develop Methanol-to-Gasoline to Avoid Risks of Over-Capacity显示文摘Marketing price of energy and chemical products are dropping dramatically pulled by the increasingly significant economic de-pression resulted from the recent US financecrisis.Prices | By Li Wenhuai and Hu Jinxian,SICC,CAS Xia Lei,ASIACHEM Consulting | 2008 | China Chemical Reporter2008，，33： | 0 |
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