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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Susceptibility variations of multiple origins of loess from the Ily Basin(NW China)显示文摘The magnetic susceptibility of loess from the Ily Basin,northwestern China shows maximum values in S0 paleosols but minimum values in other paleosols,the mechanism of which has been well debated.In this work,systematic magnetic measurements were made on a representative section from Neleke county.The results show that the loess horizons(L1,L2 and L3) have multi-domain magnetite grains of aeolian origin,S0 is characterized by production of pedogenetic ultrafine-grained ferrimagnetic minerals,and the other paleosols(S1,S2,and S3) are characterized by the formation of nonferrimagnetic minerals associated with waterlogging.The correlation between the low concentration of ferrimagnets,high paramagnetic content,high magnetic coercivity remanence,fine ferrimagnetic grain size and intensified pedogenesis suggest two competing processes of pedogenetic enhancement and pedogenetic depletion in the lower paleosols.Pedogenetic depletion dominates and is responsible for the low susceptibility.Changes in magnetic grain size distribution occur during pedogenetic depletion.The susceptibility variations are of multiple origins in the loess of the Ily Basin.Pedogenetic enhancement,pedogenetic depletion,and allochthonous input of magnetic minerals should all be taken into account to explain the variations of magnetic parameters. | CHEN Qu LIU XiuMing HELLER F HIRT Ann M LU Bin GUO XueLian MAO XueGang ZHAO GuoYong FENG Hua GUO Hui | 2012 | Chinese Science Bulletin2012，57，15： | 9 |
| 3 | High urinary bisphenol A concentra- tions in workers and possible laboratory abnormalities 显示文摘 | Wang F Hua J Chen M | 2012 | Oceup Environ Med2012，69，： | 1 |
| 4 | Structural charac- terization of a 2 - O - acetylglucomannan from Dendrobium officinale stem 显示文摘 | Hua Y F Zhang M Fu C X | 2004 | Carbohydrate Re- search2004，339，： | 1 |
| 5 | 查看详情显示文摘 | Dong W Y Sun Y J Lee C W Hua W M Lu X C Shi Y F Zhang S C Chen J M Zhao D Y | | 0，，： | 1 |
| 6 | Economical and green synthesis of bagasse-derived fluorescent carbon dots for biomedical applications 显示文摘 | Du F Y Zhang M M Li X F Li J N Jiang X Y Li Z Hua Y Shao G H Jin J Shao Q X | 2014 | Nanotechnology2014，25，31： | 1 |
| 7 | Regulation of MntH by a dual Mn(11)- and Fe(11)-dependent transcriptional repressor (DR2539) in Deinococcus radiodurans显示文摘 | Sun H X Li M F Xu G Z Chen H Jiao J D Tian B Wang L Y Hua Y J | 2012 | PLoS One2012，7，35： | 1 |
| 8 | Catalytic decomposition of NzO over Cu-ZSM-5 nanosheets显示文摘 | Zou W Yde P F Hua W M | 2014 | J Mol CataA: Chem2014，394，1： | 1 |
| 9 | A Mur regulator protein in the extremophilic bacterium Deinococcus radiodurans显示文摘 | Hussain Shah A M Zhao Y Wang Y F Yan G Q Zhang Q K Wang L Y Tian B Chen H Hua Y J | 2014 | PLoS One2014，9，10： | 1 |
| 10 | Analysis and finite element approximation of a coupled,continuum pipe-flow/darcy model for flow in porous media with embedded conduits显示文摘 | Cao Y Z Gunzburger M Hua F Wang X M | | 0，，： | 1 |
| 11 | Robust delay-dependent exponential stability of uncertain stochastic system with time-varying delay显示文摘 | HUA M DENG F LIU X | 2010 | Circuits Syst Signal Process2010，29，： | 1 |
| 12 | An improved fullbridge zero-voltage-switched pwm converter using a saturable inductor显示文摘 | HUA G LEE F C JOVANOVIC M M | 1991 | IEEE PESC1991，，： | 1 |
| 13 | Design-based Spatial Sampling: Theory and Implementation 显示文摘 | WANG J F JIANG C S HUA M G | | Environ- mental Modelling and Software0，40，： | 1 |
| 14 | Internal promoter characterization and expression of the Deinococcus radiodurans pprI-folP gene cluster显示文摘 | Gao G J Le D H Huang L F Lu H M Narumi I Hua Y J | 2006 | Fems Microbiology Letters2006，257，2： | 1 |
| 15 | A simple method to calculate contact factor used in average flow model显示文摘 | MENG F M WANG Q J HUA D | 2010 | Journal of Tribology2010，132，2： | 1 |
| 16 | Structural modification of soyprotein by the lipid peroxidation product malondialdehyde 显示文摘 | Wu W Zhang C M Hua Y F | 2009 | Journal of the Science of Food and Agriculture2009，89，8： | 1 |
| 17 | Preparation and antioxi-dant activity of wheat gluten hydrolysates (WGHs) using ul- trafiltration membranes 显示文摘 | Kong X Z Zhou H M Hua Y F | 2008 | Journal of the Science of Food and Agriculture2008，88，5： | 1 |
| 18 | Microbial Response to Repeated Treatments of Manure Containing Sulfadiazine and Chlortetracyeline in Soil显示文摘 | HUA F HAN Y L YIN Y M | 2014 | Journal of Environmen- tal Science and Health Part B2014，49，8： | 1 |
| 19 | Effects of Bcl-2 levels on fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predietions 显示文摘 | HUA F COMEJO M G CARDONE M H | 2005 | JImmunol2005，175，2： | 1 |
| 20 | Offcongruent LiNbO3 crystals prepared by Li-poor vapor transport equilibration for integrated optics显示文摘 | Hua P R Zhang D L Cui Y M Wang Y F Pun E Y B | | 0，，07： | 1 |
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