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| 1 | Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein显示文摘真核细胞的房间的最惹人注目的形态特征是各种各样的围住膜的分隔空间的存在。包括细胞器和短暂运输中介,这些分隔空间不是静态的。更确切地说,蛋白质和膜的动态交换被需要维持细胞的动态平衡。膜动员的最戏剧的例子之一在 macroautophagy 的过程期间被看见。Macroautophagy 是为长寿蛋白质和细胞器的降级的主要细胞的小径。响应环境暗示,例如饥饿或应力的另外的类型,房间生产唯一的膜结构, phagophore.The phagophore 扣押它形成一个双膜 cytosolic 泡的细胞质, anautophagosome。在结束之后, autophagosome 与溶酶体熔化或在酵母的一个液泡,它交付水疗院放射激光与它的货物,和产生大分子一起毁坏内部 autophagosome 膜回来被释放进 cytosol 因为 reuse.Autophagy 因此是正在骑车过程,允许房间熬过滋养的限制的时期;然而,它有一个更宽的生理的角色,参予开发和老化,并且另外在对病原体侵略,癌症和某些 neurodegenerative 的保护疾病。在许多情况中, autophagy 的角色通过 autophagy 相关的蛋白质的研究被识别, Atg6/Beclin 1。这蛋白质是类脂化合物 kinase 建筑群的部分,并且最近的研究建议它在协调 autophagy 并且在反对 apoptosis 的细胞的死亡过程的 thecytoprotective 功能起一个中央作用。这里,我们总结我们 Atg6/Beclin 的当前的知识 1 在在细胞的不同模型有机体和它的唯一的功能。 | Yang Cao Daniel J Klionsky | 2007 | Cell Research2007，17，10： | 100 |
| 2 | 人类感染新型H7N9禽流感病毒显示文摘2013年4月11日,《新英格兰医学杂志》在线发表了来自中国疾控中心、上海公共卫生临床中心、上海市第五人民医院、上海疾控中心、安徽疾控中心等单位的中国科学家的最新研究成果《人感染新型H7N9禽流感病毒》。介绍了我国科学家发现人感染H7N9禽流感病毒的重要成果和意义. | 李侗曾 Gao RB Cao B Hu YW | 2013 | 北京医学2013，35，6： | 352 |
| 3 | Efficient genome editing in plants using a CRISPR/Cas system显示文摘 | Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu | 2013 | Cell Research2013，23，10： | 211 |
| 4 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 5 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 6 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 7 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 8 | The origin, transmission and clinical therapies on coronavirus disease 2019(COVID-19) outbreak——an update on the status显示文摘An acute respiratory disease,caused by a novel coronavirus(SARS-CoV-2,previously known as 2019-nCoV),the coronavirus disease 2019(COVID-19)has spread throughout China and received worldwide attention.On 30 January 2020,World Health Organization(WHO)officially declared the COVID-19 epidemic as a public health emergency of international concern.The emergence of SARS-CoV-2,since the severe acute respiratory syndrome coronavirus(SARSCoV)in 2002 and Middle East respiratory syndrome coronavirus(MERS-CoV)in 2012,marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century.As of 1 March 2020,a total of 87,137 confirmed cases globally,79,968 confirmed in China and 7169 outside of China,with 2977 deaths(3.4%)had been reported by WHO.Meanwhile,several independent research groups have identified that SARS-CoV-2 belongs toβ-coronavirus,with highly identical genome to bat coronavirus,pointing to bat as the natural host.The novel coronavirus uses the same receptor,angiotensin-converting enzyme 2(ACE2)as that for SARS-CoV,and mainly spreads through the respiratory tract.Importantly,increasingly evidence showed sustained human-tohuman transmission,along with many exported cases across the globe.The clinical symptoms of COVID-19 patients include fever,cough,fatigue and a small population of patients appeared gastrointestinal infection symptoms.The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes,which may be associated with acute respiratory distress syndrome(ARDS)and cytokine storm.Currently,there are few specific antiviral strategies,but several potent candidates of antivirals and repurposed drugs are under urgent investigation.In this review,we summarized the latest research progress of the epidemiology,pathogenesis,and clinical characteristics of COVID-19,and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. | Yan-Rong Guo Qing-Dong Cao Zhong-Si Hong Yuan-Yang Tan Shou-Deng Chen Hong-Jun Jin Kai-Sen Tan De-Yun Wang Yan Yan | 2020 | Military Medical Research2020，7，1： | 123 |
| 9 | Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020显示文摘Background:Cancer is one of the leading causes of death globally,but its burden is not uniform.GLOBOCAN 2020 has newly updated the estimates of cancer burden.This study summarizes the most recent changing profiles of cancer burden worldwide and in China and compares the cancer data of China with those of other regions.Methods:We conducted a descriptive secondary analysis of the GLOBOCAN 2020 data.To depict the changing global profile of the leading cancer types in 2020 compared with 2018,we extracted the numbers of cases and deaths in 2018 from GLOBOCAN 2018.We also obtained cancer incidence and mortality from the 2015 National Cancer Registry Report in China when sorting the leading cancer types by new cases and deaths.For the leading cancer types according to sex in China,we summarized the estimated numbers of incidence and mortality,and calculated China’s percentage of the global new cases and deaths.Results:Breast cancer displaced lung cancer to become the most leading diagnosed cancer worldwide in 2020.Lung,liver,stomach,breast,and colon cancers were the top five leading causes of cancer-related death,among which liver cancer changed from the third-highest cancer mortality in 2018 to the second-highest in 2020.China accounted for 24%of newly diagnosed cases and 30%of the cancer-related deaths worldwide in 2020.Among the 185 countries included in the database,China’s age-standardized incidence rate(204.8 per 100,000)ranked 65th and the age-standardized mortality rate(129.4 per 100,000)ranked 13th.The two rates were above the global average.Lung cancer remained the most common cancer type and the leading cause of cancer death in China.However,breast cancer became the most frequent cancer type among women if the incidence was stratified by sex.Incidences of colorectal cancer and breast cancer increased rapidly.The leading causes of cancer death varied minimally in ranking from 2015 to 2020 in China.Gastrointestinal cancers,including stomach,colorectal,liver,and esophageal cancers,contributed to a massive burden of cancer for both sexes.Conclusions:The burden of breast cancer is increasing globally.China is undergoing cancer transition with an increasing burden of lung cancer,gastrointestinal cancer,and breast cancers.The mortality rate of cancer in China is high.Comprehensive strategies are urgently needed to target China’s changing profiles of the cancer burden. | Wei Cao Hong-Da Chen Yi-Wen Yu Ni Li Wan-Qing Chen | 2021 | Chinese Medical Journal2021，，7： | 982 |
| 10 | Current cancer situation in China:good or bad news from the 2018 Global Cancer Statistics?显示文摘Cancer is the leading cause of death in China and depicting the cancer pattern of China would provide basic knowhows on how to tackle it more effectively.In this study we have reviewed several reports of cancer burden,including the Global cancer statistics 2018 and Cancer statistics in China,2015,along with the GLOBCAN 2018 online database,to investigate the differences of cancer patterns between China,the United States(USA)and the United Kingdom(UK).An estimated 4.3 million new cancer cases and 2.9 million new cancer deaths occurred in China in 2018.Compared to the USA and UK,China has lower cancer incidence but a 30%and 40%higher cancer mortality than the UK and USA,among which 36.4%of the cancer-related deaths were from the digestive tract cancers(stomach,liver,and esophagus cancer)and have relatively poorer prognoses.In comparison,the digestive cancer deaths only took up≤5%of the total cancer deaths in either USA or UK.Other reasons for the higher mortality in China may be the low rate of early-stage cancers at diagnosis and non-uniformed clinical cancer treatment strategies performed by different regions.China is undergoing the cancer transition stage where the cancer spectrum is changing from developing country to developed country,with a rapidly increase cancer burden of colorectal,prostate,female breast cancers in addition to a high occurrence of infection-related and digestive cancers.The incidence of westernized lifestyle-related cancers in China(i.e.colorectal cancer,prostate,bladder cancer)has risen but the incidence of the digestive cancers has decreased from 2000 to 2011.An estimated 40%of the risk factors can be attributed to environmental and lifestyle factors either in China or other developed countries.Tobacco smoking is the single most important carcinogenic risk factor in China,contributing to~24.5%of cancers in males.Chronic infection is another important preventable cancer contributor which is responsible for~17%of cancers.Comprehensive prevention and control strategies in China should include effective tobacco-control policy,recommendations for healthier lifestyles,along with enlarg-ing the coverage of effective screening,educating,and vaccination programs to better sensitize greater awareness control to the general public. | Rui-Mei Feng Yi-Nan Zong Su-Mei Cao Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 675 |
| 11 | Cancer burden of major cancers in China:A need for sustainable actions显示文摘Cancer is still a major health problem in China although numerous efforts have been made for its prevention and control.Findings from this study showed that lung cancer remains the most common type of cancer diagnosed,and was attributed to nearly 30%of all cancer-related deaths.The incidence of the five most common cancers,in China,in 2015,including cancers of the lungs,stomach,colorectum,liver and breast,accounted for almost 60%of all cancers diagnosed.The high cancer burden in China highlights the need for further improvement in health education,professional training and the building up an anti-cancer network for introducing and implementing sustainable actions for cancer control. | Maomao Cao He Li Dianqin Sun Wanqing Chen | 2020 | Cancer Communications2020，40，5： | 140 |
| 12 | Cancer incidence,mortality,and burden in China:a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020显示文摘Background:Cancer is one of the leading causes of death and a main economic burden in China.Investigating the differences in cancer patterns and control strategies between China and developed countries could provide reference for policy planning and contribute to improving cancer control measures.In this study,we reviewed the rates and trends of cancer incidence and mortality and disability-adjusted life year(DALY)burden in China,and compared them with those in the United States(US)and the United Kingdom(UK).Methods:Cancer incidence,mortality,and DALY data for China,US and UK were obtained fromtheGLOBOCAN2020 online database,Global Burden of Disease(GBD)2019 study,and Cancer Incidence in Five Continents plus database(CI5 plus).Trends of cancer incidence and mortality in China,US,and UK were analyzed using Joinpoint regression models to calculate annual percent changes(APCs)and identify the best-fitting joinpoints.Results:An estimated 4,568,754 newly diagnosed cancer cases and 3,002,899 cancer deaths occurred in China in 2020.Additionally,cancers resulted in 67,340,309 DALYs in China.Compared to the US and UK,China had lower cancer incidence but higher cancer mortality andDALY rates.Furthermore,the cancer spectrum of China was changing,with a rapid increase incidence and burden of lung,breast,colorectal,and prostate cancer in addition to a high incidence and heavy burden of liver,stomach,esophageal,and cervical cancer.Conclusions:The cancer spectrum of China is changing from a developing country to a developed country.Population aging and increase of unhealthy lifestyles would continue to increase the cancer burden of China.Therefore,the Chinese authorities should adjust the national cancer control program with reference to the practices of cancer control which have been well-established in the developed countries,and taking consideration of the diversity of cancer types by of different regions in China at the same time. | Haibo Qiu Sumei Cao Ruihua Xu | 2021 | Cancer Communications2021，41，10： | 194 |
| 13 | Cancer statistics in China and United States,2022:profiles,trends,and determinants显示文摘Background:The cancer burden in the United States of America(USA)has decreased gradually.However,China is experiencing a transition in its cancer profiles,with greater incidence of cancers that were previously more common in the USA.This study compared the latest cancer profiles,trends,and determinants between China and USA.Methods:This was a comparative study using open-source data.Cancer cases and deaths in 2022 were calculated using cancer estimates from GLOBOCAN 2020 and population estimates from the United Nations.Trends in cancer incidence and mortality rates in the USA used data from the Surveillance,Epidemiology,and End Results program and National Center for Health Statistics.Chinese data were obtained from cancer registry reports.Data from the Global Burden of Disease 2019 and a decomposition method were used to express cancer deaths as the product of four determinant factors.Results:In 2022,there will be approximately 4,820,000 and 2,370,000 new cancer cases,and 3,210,000 and 640,000 cancer deaths in China and the USA,respectively.The most common cancers are lung cancer in China and breast cancer in the USA,and lung cancer is the leading cause of cancer death in both.Age-standardized incidence and mortality rates for lung cancer and colorectal cancer in the USA have decreased significantly recently,but rates of liver cancer have increased slightly.Rates of stomach,liver,and esophageal cancer decreased gradually in China,but rates have increased for colorectal cancer in the whole population,prostate cancer in men,and other seven cancer types in women.Increases in adult population size and population aging were major determinants for incremental cancer deaths,and case-fatality rates contributed to reduced cancer deaths in both countries.Conclusions:The decreasing cancer burden in liver,stomach,and esophagus,and increasing burden in lung,colorectum,breast,and prostate,mean that cancer profiles in China and the USA are converging.Population aging is a growing determinant of incremental cancer burden.Progress in cancer prevention and care in the USA,and measures to actively respond to population aging,may help China to reduce the cancer burden. | Changfa Xia Xuesi Dong He Li Maomao Cao Dianqin Sun Siyi He Fan Yang Xinxin Yan Shaoli Zhang Ni Li Wanqing Chen | 2022 | Chinese Medical Journal2022，，5： | 827 |
| 14 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 15 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 16 | Characterizing ionic species in PM_(2.5) and PM_(10) in four Pearl River Delta cities,South China显示文摘PM2.5 和 PM10 样品在珍珠河三角洲(PRD ) 在四个主要城市被收集,华南,在在 2002 的冬季和夏天期间。六个水溶性的离子, Na (+) , NH4 (+) , K (+) , Cl (?) , NO3 (?) 和 SO4 (2 ?) 用离子层析被测量。平均,离子的种类为 PM2.5 和 PM10 占了 53.3% 和 40.5% ,分别地在冬季并且 39.4% 和 35.2% ,分别地在里面夏天。象硫酸盐,硝酸盐和铵那样的第二等的离子说明了全部的离子的种类的主要部分。硫酸盐是硝酸盐跟随的最丰富的种类。总的来说,一个地区性的污染趋势被看那有另外的 PRD 城市里的比那些的广州城市里的硫酸盐,硝酸盐和铵的更高的集中。重要季节变化也在冬季与种类的高水平被观察,但是在夏天降低。当高度本地工业排出物装载趋于败坏时,亚洲季风系统为在在夏天的 PRD 的空气污染物的移动和散开是有利的空气质量也。NO3 (?)/SO4 (2 )(?) 比率显示活动来源更加有贡献到城市的喷雾器,并且静止来源不应该被忽视。除主要排出物以外,在有利天气条件下面的复杂大气的反应应该在 PRD 区域为主要排放的控制被付更多的注意。 | LAI Sen-chao ZOU Shi-chun CAO Jun-ji LEE Shun-cheng HO Kin-fai | 2007 | Journal of Environmental Sciences2007，19，8： | 76 |
| 17 | Investigation on emission factors of particulate matter and gaseous pollutants from crop residue burning显示文摘微粒物质(下午)的排放因素,元素碳( EC ),器官的碳( OC ), SO2 , NOx ,公司, CO2 ,和十个离子(Na+,NH4+,K+,Mg2+,Ca2+, F ?, Cl ?, NO2 ?, NO3 ?, SO42 ?)从在农村中国的通常生产的罪残茬的四种类型的国内烧被估计:稻秸,麦秸,玉米 stover,和棉花越过中国搜索区域,它从代表是镇定的。一个燃烧塔被设计模仿农民在农村中国在下面烧了他们的罪残茬的煮的条件,到措施排放因素。,结果证明那麦秸在四罪残茬之中有最高的排放因素彻底的下午(8.75 g/kg ) 玉米 stover 和麦秸分别地为 EC (0.95 g/kg ) 和 OC (3.46 g/kg ) 有最高的排放因素。玉米 stover 也作为有最高的排放因素介绍没有, NOx,和 CO2,麦秸,稻秸,和棉花梗分别地有 NO2, SO2,和公司的最高的排放因素。水溶性的离子, K+ 和 Cl ? ,从所有庄稼有最高的排放因素。麦秸有阳离子种类和 F 的一个相对更高的排放因素 ? , Cl ? , NO2 吗?比另外的残余。 | CAO Guoliang ZHANG Xiaoye GONG Sunling ZHENG Fangcheng | 2008 | Journal of Environmental Sciences2008，20，1： | 61 |
| 18 | Heavy metals in rice and garden vegetables and their potential health risks to inhabitants in the vicinity of an industrial zone in Jiangsu, China显示文摘Contamination of soil and agricultural products by heavy metals resulting from rapid industrial development has caused major concern. In this study, we investigated heavy metal (Cu, Zn, Pb, Cr, Hg and Cd) concentrations in rice and garden vegetables, as well as in cultivated soils, in a rural-industrial developed region in southern Jiangsu, China, and estimated the potential health risks of metals to the inhabitants via consumption of locally produced rice and garden vegetables. A questionnaire-based survey on dietary consumption rates of foodstuffs showed that rice and vegetables accounted for 64% of total foodstuffs consumed, and over 60% of rice and vegetables were grown in the local region. Average concentrations of Cr, Cu, Zn, Cd, Hg and Pb were 0.75, 2.64, 12.00, 0.014, 0.006 and 0.054 mg/kg dw (dry weight) in rice and were 0.67, 1.18, 4.34, 0.011, 0.002 and 0.058 mg/kg fw (fresh weight) in garden vegetables, respectively. These values were all below the maximum allowable concentration in food in China except for Cr in vegetables. Leafy vegetables had higher metal concentrations than solanaceae vegetables. Average daily intake of Cr, Cu, Zn, Cd, Hg and Pb through the consumption of rice and garden vegetables were 5.66, 16.90, 74.21, 0.10, 0.04 and 0.43 μg/(kg·day), respectively. Although Hazard Quotient values of individual metals were all lower than 1, when all six metal intakes via self-planted rice and garden vegetables were combined, the Hazard Index value was close to 1. Potential health risks from exposure to heavy metals in self-planted rice and garden vegetables need more attention. | Hongbin Cao Jianjiang Chen Jun Zhang Hui Zhang Li Qiao Yi Men | 2010 | Journal of Environmental Sciences2010，22，11： | 61 |
| 19 | Evaluation of the traditional Chinese medicine Shensongyangxin capsule on treating premature ventricular contractions: a randomized, double-blind, controlled multicenter trial显示文摘背景早熟的室的收缩(PVC ) 是治疗为掉进窘境的心律不齐的最普通的类型之一。以前的临床的申请证明繁体中文药 Shensongyangxin (SSYX ) 囊为 PVC 的治疗是有效的。这使随机化的临床的试用试图进一步在对待 PVC.Methods 上评估 SSYX 囊的功效和安全有经常的 PVC 与或没有器官的心疾病和正常心脏的功能的题目在学习被注册。主要端点是在有 SSYX 囊的八星期的药以后的 PVC 数字的变化。包括的第二等的端点与 PVC 和 SSYX 囊的安全评估有关的临床的症状变化。完全, 188 个 PVC 病人随机在非器官的心疾病 PVC 试用被注册并且口头上地拿了 SSYX 囊或类似物(三每天预定, 4 囊一次) 。671 个 PVC 病人的一个总数随机在器官的心疾病 PVC 试用被注册,并且口头上地拿了任何一个 SSYX 囊(三每天预定, 4 囊一次) 或 mexiletine 药片(三每天预定, 150 mg 时间) 。PVC 与 24 小时的 Holter 心电图被监视并且计算。在有 SSYX capsule.Results SSYX 囊的药显著地减少了前后,平淡的血,肝和肾功能被测试 PVC 数字并且在病人减轻了相关症状与或没有器官的心疾病。在非器官的心疾病组, SSYX 囊和安慰剂减少了从 12561.34 猠潣敲?的 PVC ???????鷓???鮰?钱?????????????????颓陎???讂??????鶝???????錄?吗??????疞????鮪鴿?铳?????????????? T ?? | ZOU Jian-gang ZHANG Jian JIA Zhen-hua CAO Ke-jiang | 2011 | Chinese Medical Journal2011，，1： | 70 |
| 20 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
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