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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | Markov Chain-based Degree Distributions of Evolving Networks显示文摘In this paper, we study a class of stochastic processes, called evolving network Markov chains, in evolving networks. Our approach is to transform the degree distribution problem of an evolving network to a corresponding problem of evolving network Markov chains. We investigate the evolving network Markov chains, thereby obtaining some exact formulas as well as a precise criterion for determining whether the steady degree distribution of the evolving network is a power-law or not. With this new method, we finally obtain a rigorous, exact and unified solution of the steady degree distribution of the evolving network. | Xiang Xing KONG Zhen Ting HOU Ding Hua SHI Quan Rong CHEN Qing Gui ZHAO | 2012 | Acta Mathematica Sinica,English Series2012，28，10： | 2 |
| 3 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 4 | The common anesthetic, sevoflurane, induces apoptosis in A549 lung alveolarepithelial cells显示文摘 | Gui?Hua Wei Juan Zhang Da?Qing Liao Zhuo Li Jing Yang Nan?Fu Luo Yan Gu | 2014 | Molecular Medicine Reports2014，，1： | 1 |
| 5 | MURICATALIN, A NEW POLYKETIDE FROM ANNONA MURICATA (ANNONACEAE)显示文摘MURICATALIN,ANEWPOLYKETIDEFROMANNONAMURICATA(ANNONACEAE)HuaQingGUI;jingGuangYU;andZhiLiYU￣aInstituteofMedicinalPlantDevelopme... | Hua Qing GUI jing Guang YU and Zhi Li YU￣aInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing 100O94 | 1995 | Chinese Chemical Letters1995，6，1： | 1 |
| 6 | A NEW METHOD FOR THE TREATMENT AND UTILIZATION OF THE WASTE GAS NOx----THE PREOXIDATION OF 2-OCTANOL BY ABSORBING NOx显示文摘A new method is proposed to absorb the NOx into an organic compound,2-octanol.The absorption efficiency reaches up to 96-99%,and the NOx emission level is decreased from1.0×10~4-3.0×10~5 to 60-680Ppm.In the absorption process,2-octanol is preoxidized.And thenit is further oxidized into hexanoic acid with nitric acid.In this way,20% of nitric acid is savedfor the same yield of hexanoic acid. | Shen Shong ZHANG Fu Gui LU Qing Zhi ZHANG (Department of Chemistry,Henan Normal University,Xinxiang,453002) Gen Suo ZHAO (Henan Institute of Chemistry,Chinese Academy of Sciences,Zhenzhong,450002) Guo Xiong HUA (Analytical Center,Fushun Petroleum Institute,Fushun,113001) | 1991 | Chinese Chemical Letters1991，2，9： | 0 |
| 7 | Mediating the Local Oxygen‑Bridge Interactions of Oxysalt/Perovskite Interface for Defect Passivation of Perovskite Photovoltaics显示文摘Passivation,as a classical surface treatment technique,has been widely accepted in start-of-the-art perovskite solar cells(PSCs)that can effectively modulate the electronic and chemical property of defective perovskite surface.The discovery of inorganic passivation compounds,such as oxysalts,has largely advanced the efficiency and lifetime of PSCs on account of its favorable electrical property and remarkable inherent stability,but a lack of deep understanding of how its local configuration affects the passivation effectiveness is a huge impediment for future interfacial molecular engineering.Here,we demonstrate the central-atom-dependent-passivation of oxysalt on perovskite surface,in which the central atoms of oxyacid anions dominate the interfacial oxygen-bridge strength.We revealed that the balance of local interactions between the central atoms of oxyacid anions(e.g.,N,C,S,P,Si)and the metal cations on perovskite surface(e.g.,Pb)generally determines the bond formation at oxysalt/perovskite interface,which can be understood by the bond order conservation principle.Silicate with less electronegative Si central atoms provides strong O-Pb motif and improved passivation effect,delivering a champion efficiency of 17.26%for CsPbI2Br solar cells.Our strategy is also universally effective in improving the device performance of several commonly used perovskite compositions. | Ze Qing Lin Hui Jun Lian Bing Ge Ziren Zhou Haiyang Yuan Yu Hou Shuang Yang Hua Gui Yang | 2021 | Nano-Micro Letters2021，13，11： | 0 |
| 8 | Determination of Periplocymarin in Human Blood and Urine by High-Performance Liquid Chromatography-Mass Spectrometry显示文摘A simple,rapid and sensitive liquid chromatography with tandem mass spectrometry method for the determination of periplocymarin in human blood and urine was developed.The digoxin‑d3 was used as an internal standard.Periplocymarin and digoxin‑d3(IS)were processed with ethyl acetate by liquid–liquid extraction.The chromatographic separation was performed on a Shim‑pack XR‑ODSIII C18 column with a 7 min gradient elution using methanol‑ammonium formate(5 mmol/L)as mobile phase at a flow rate of 0.3 mL/min(65:35,v/v).The detection was performed on a triple quadrupole tandem mass spectrometer using positive‑ion mode electrospray ionization in selected reaction monitoring mode.The periplocymarin was well separated from the internal standard.Two calibration curves were linear within the concentration range 0.01–1µg/mL.The limit of detection and quantification of blood and urine samples were both estimated at 0.005 and 0.01µg/mL.The interday and intraday precisions,accuracy,and recovery were assessed to verify this method.The results showed that the method was suitable for the determination of periplocymarin in forensic toxicological analysis and clinical diagnosis. | Chen Jian Xia Wei Qing Tao Chen Fan Wu Hao Fu Ying Qing Wu Zhi Gui Dai Xin Hua Ye Yi Yan You Yi Liao Lin Chuan | 2017 | Journal of Forensic Science and Medicine2017，3，4： | 0 |
| 9 | An Efficient Approach to 6, 7-Disubstituted-1H-quinoxalin-2-ones显示文摘A novel approach to the synthesis of 6, 7-disubstituted-1H-quinoxalin-2-ones is described The title compounds were regioselectively prepared by starting from substituted phenylamines and chloroacetyl chloride through the efficient sequence of acylation, nitration, reduction, intramolecular alkylation, and oxidation. | Xun LI Qing Ping HU Xue Gui CUI Dong Hua WANG College of Pharmacy, Shandong University, Jinan 250100 College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072 | 2004 | Chinese Chemical Letters2004，15，12： | 0 |
| 10 | Quantitative Study of Iron Metabolism-related Genes Expression in Rat显示文摘Objective To investigate the multiple iron metabolism-related genes expression,its regulation by iron and the expression correlation among the genes in rat tissues.Methods Two groups(n=30) of Sprague-Dawley female weanling rats were fed with a control diet and an iron deficient diet respectively for 4 weeks.All rats were then sacrificed,and blood and tissue samples were collected.The routine blood examination was performed with a veterinary automatic blood cell analyzer.Elemental iron levels in liver,spleen and serum were determined by atomic absorption spectrophotometry.The mRNA expression of genes was detected by real-time fluorescence quantitative PCR.Results After 4 weeks,the hemoglobin(Hb) level and red blood cell(RBC) count were significantly lower in the iron deficient group compared with those in the control group.The iron levels in liver,spleen and serum in the iron deficient group were significantly lower than those in the control group.In reference to small intestine,the relative expression of each iron-related gene varied in the different tissues.Under the iron deficiency,the expression of these genes changed in a tissue-specific manner.The expression of most of the genes significantly correlated in intestine,spleen and lung,but few correlated in liver,heart and kidney.Conclusion Findings from our study provides new understandings about the relative expression,regulation by iron and correlation among the mRNA expressions of transferrin receptors 1 and 2,divalent metal transporter 1,ferritin,iron regulation proteins 1 and 2,hereditary hemochromatosis protein,hepcidin,ferroportin 1 and hephaestin in intestine,liver,spleen,kidney,heart,and lung of rat. | LI Yan Qin BAI Bin ZHENG Quan Qing YAN Hong ZHUANG Gui Hua | 2013 | Biomedical and Environmental Sciences2013，26，10： | 0 |
| 11 | A new incision for neck dissection-Zhang's incision显示文摘 | Liao Gui Qing Su Kai Chen Zhuo Hui Jiao Guo Hua | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 12 | 3-to 24-month Follow-up on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge:Results from a Prospective,Multicenter Study显示文摘Objective Coronavirus disease 2019(COVID-19)and tuberculosis(TB)are major public health and social issues worldwide.The long-term follow-up of COVID-19 with pulmonary TB(PTB)survivors after discharge is unclear.This study aimed to comprehensively describe clinical outcomes,including sequela and recurrence at 3,12,and 24 months after discharge,among COVID-19 with PTB survivors.Methods From January 22,2020 to May 6,2022,with a follow-up by August 26,2022,a prospective,multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in China.Clinical outcomes,including sequela,recurrence of COVID-19,and PTB survivors,were collected via telephone and face-to-face interviews at 3,12,and 24 months after discharge.Results Thirty-two COVID-19 with PTB survivors were included.The median age was 52(45,59)years,and 23(71.9%)were men.Among them,nearly two-thirds(62.5%)of the survivors were moderate,three(9.4%)were severe,and more than half(59.4%)had at least one comorbidity(PTB excluded).The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6%at 3 months to 15.8%at 24 months,with anxiety having a higher proportion over a follow-up.Cough and amnesia recovered at the 12-month follow-up,while anxiety,fatigue,and trouble sleeping remained after 24months.Additionally,one(3.1%)case presented two recurrences of PTB and no re-positive COVID-19during the follow-up period.Conclusion The proportion of long symptoms in COVID-19 with PTB survivors decreased over time,while nearly one in six still experience persistent symptoms with a higher proportion of anxiety.The recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention. | WANG Jing Ya ZONG Xing Yu WU Gui Hui QI Yuan Lin LI Hui Zhen JI Xin Yu TONG Lin ZHANG Lei YANG Ming Bo YANG Pu Ye LI Ji Ke XIAO Fu Rong ZHANG Lin Song HU Yun Hong LIU Hong De XU Shou Fang SUN Sheng WU Wei MAO Ya LI Min Qing HOU Hao Hua GONG Zhao Yuan GUO Yang JIAO Li Wen QIN Jin WANG Ding Yi WANG Fang GUAN Li LIN Gang MA Yan WANG Yan Ping SHI Nan Nan | 2022 | Biomedical and Environmental Sciences2022，35，12： | 0 |
| 13 | Synthesis of Trihydrocarbyltin Chloride Containing Silicon and Crystal Structure of (p-Cl-C_6H_4Me_2SiCH_2)_3SnCl显示文摘A series of trihydrocarbyltin chlorides containing silicon was synthesized. The acaricidal activity was determined and the structure activity relationship was tried to be found out with the hydrophobic parameter. | ZHONG Gui yun, LIU Hua and XIE Qing lan * Institute of Elemento organic Chemistry, Nankai University, Tianjin 300071, P. R. China | 2002 | Chemical Research in Chinese Universities2002，18，3： | 0 |
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