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| 1 | Four new species of the genus Hymenoscyphus (fungi) based on morphology and molecular data显示文摘Four new species of Hymenoscyphus (H. brevicellulus, H. hyaloexcipulus, H. microcaudatus, and H. subsymmetricus) and a new Chinese record (H. subpallescens) are described. These five species share common characteristics: small apothecia (<3mm in diameter); hymenium whitish, pale yellow, to yellow in color; ectal excipulum of textura prismatica; asci arising from simple septa; ascospores scutuloid and guttulate; saprophytic nutrition; and leaf habitats, except for H. subsymmetricus, which grows on herbaceous stems. Phylogenetic analyses of internal transcribed spacer nuclear ribosomal DNA sequences, the universal DNA barcode for fungi, for 16 species in the genus indicated that these taxa were closely related to H. microserotinus, in accordance with their morphological features, but represented independent species. The distinguishing features of each new species from its relatives are discussed, and their phylogenetic relationships explored. | ZHENG HuanDi ZHUANG WenYing | 2013 | Science China(Life Sciences)2013，56，1： | 8 |
| 2 | Review and Comprehensive Analysis of Deaggregation and Separation Methods for Asphaltene Aggregates显示文摘Asphaltenes generally exist in the form of molecular aggregates in crude oil or in petroleum residues,and asphaltene aggregates can usually cause serious problems to oil exploitation,transportation,and processing.Achieving deaggregation and separation of asphaltene aggregates is a premise and basis for molecular characterization and processing of heavy oils.Aiming at the intermolecular interactions in asphaltene molecular aggregates,it has proposed and summarized that aspahltene aggregates can be subject to deaggregation by means of five approaches,including solvent diluting,removing active sites,moderate heating,ultrasonication and on-line molecular collision.Moreover,asphaltenes can be further separated to narrow fractions for molecular-level research based on polarity difference,molecular size difference,acid-base properties,and reactivity difference. | Cai Xinheng Long Jun Dong Ming Wang Wei Hou Huandi Tian Songbai | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，2： | 3 |
| 3 | Linkage of Aromatic Ring Structures in Saturates, Aromatics, Resins and Asphaltenes Fractions of Vacuum Residues Determined by Collision-Induced Dissociation Technology显示文摘The linkage of aromatic ring structures in vacuum residues was important for the refining process. The Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS) combined with collision-induced dissociation(CID) is a powerful method to characterize the molecular structure of petroleum fractions. In this work, model compounds with different aromatic ring structures were measured by CID FT-ICR MS. The cracking of the parent ions and the generated fragment ions were able to distinguish different linkage of the model compounds. Then, vacuum residues were separated into saturates, aromatics, resins and asphaltenes fractions(SARA), and each fraction was characterized by CID technology. According to the experimental results, the aromatic rings in saturates and aromatics fractions were mainly of the island-type structures, while the aromatic rings in resins and asphaltenes fractions had a significant amount of archipelago-type structures. | Wang Wei Liu Yingrong Liu Zelong Hou Huandi Tian Songbai | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，1： | 3 |
| 4 | Effects of Dispersed Mo-Fe Catalysts on Catalytic Hydrothermal Conversion of Residue显示文摘Replacement of precious single metal catalysts with cost-effective,highly-dispersed composite catalysts for catalytic hydrothermal conversion of residue holds tremendous promise for the residue upgrading technologies.Organic metals were added to the feed as the oil-soluble precursors,and were transformed into the catalytic active phases in this work.Physical properties and structures of the composite catalysts had been investigated by X-ray fluorescence spectroscopy,X-ray photoelectron spectroscopy,X-ray diffraction,scanning electron microscopy and transmission electron microscopy.The composite catalysts were found to be highly efficient in the catalytic hydrothermal conversion of both the model compound and the residue.Increased metal dispersion and synergistic effects of two metals played indispensable roles in such catalytic system.Results showed that under the test conditions specified in the article,the catalyst had the best catalytic performance when the mass ratio of molybdenum to iron was 1.5. | Tao Mengying Hou Huandi Dong Ming Xu Ke | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 2 |
| 5 | In-Situ Chemosynthesis of ZnO Nanoparticles to Endow Wood with Antibacterial and UV-Resistance Properties显示文摘Hybrid wood materials have attracted considerable attention because they have combined advantages of both wood and inorganic compounds. This work investigated the microstructural morphology, thermal stability, ultraviolet(UV) stability, and antibacterial property of composites made from wood/ZnO hybrid materials through a facile in-situ chemosynthesis methods. The X-ray diffraction(XRD) and thermogravimetric analysis(TGA) results indicated that the synthesized ZnO particles had an average grain size of about 10.8 nm. The scanning electron microscopy(SEM) observations showed that ZnO nanoflowers self-assembled with nanosheets were presented in wood cell lumens and increased with increasing Zn^(2+)concentrations. ZnO nanoparticles were also generated in the wood cell wall, which was confirmed by the results of energy-dispersive spectroscopy(EDS). The TGA tests also indicated that the thermal stability of wood/ZnO hybrid materials was improved after the formation of ZnO inorganic particles. Finally, the results of antibacterial efficacy tests and UV resistance tests revealed that ZnO nanoparticles showed a promising future as antimicrobial agents against Escherichia coli(E.coli) and UV resistance agents for wood protection. | Youming Dong Yutao Yan Huandi Ma Shifeng Zhang Jianzhang Li Changlei Xia Sheldon Q.Shi Liping Cai | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 6 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 7 | Structural Characterization of Petroleum Molecules by CID FT-ICR MS with Narrow Isolation Window显示文摘High resolution tandem mass spectrometry has been applied to obtain the structure information of petroleum samples. Here, we report a method for structural characterization of crude oil molecules by the collision-induced dissociation(CID) technology coupled with the high-field Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS). The ion isolation window was narrowed down to 1 Da to distinguish the complex homologues contained in petroleum. Aromatic model compounds and crude oil samples were measured by CID FT-ICR MS at different collision energy levels. The fragmentation of model compounds with alkyl side-chains was found to be related to the size of the aromatic rings. The fragmentation of model compounds with archipelago structures depended on the length of the bridge alkylene chain. The prevalent reaction pathway of model compounds with naphthenic rings was mainly determined by the position of naphthenic rings in the molecules. On the basis of the fragmentation pathways, the structure differences of two crude oils were recognized as different content of naphthenic rings by CID technology with 1 Da isolation window. The NMR analysis was also applied to confirm the CID results. This study exhibits the great potential of CID FT-ICR MS with narrow isolation window in the structural characterization of crude oil molecules. | Liu Ling Zhang Yiwei Zhang Zhihua Hou Huandi Zhang Qundan Tian Songbai Wang Wei | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，3： | 1 |
| 8 | HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells显示文摘Purinostat Mesylate(PM)is a novel highly selective and active HDAC I/IIb inhibitor,and the injectable formulation of PM(PMF)based on the compound prescription containing cyclodextrin completely can overcome PM’s poor solubility and improves its stability and pharmacokinetic properties.Here,we showed that PM effectively repressed the survival of Ph+leukemia cells and CD34+leukemia cells from CML patients in vitro.In vivo studies demonstrated that PMF significantly prevented BCR-ABL(T315I)induced CML progression by restraining leukemia stem cells(LSCs),which are insensitive to chemotherapy and responsible for CML relapse.Mechanism studies revealed that targeting HDAC I/IIb repressed several important factors for LSCs survival including c-Myc,β-Catenin,E2f,Ezh2,Alox5,and mTOR,as well as interrupted some critical biologic processes.Additionally,PMF increased glutamate metabolism in LSCs by increasing GLS1.The combination of PMF and glutaminase inhibitor BPTES synergistically eradicated LSCs by altering multiple key proteins and signaling pathways which are critical for LSC survival and self-renewal.Overall,our findings represent a new therapeutic strategy for eliminating LSCs by targeting HDAC I/IIb and glutaminolysis,which potentially provides a guidance for PMF clinical trials in the future for TKI resistance CML patients. | Qiang Qiu Linyu yang Yunyu Feng Zejiang Zhu Ning Li Li Zheng Yuanyuan Sun Cong Pan Huandi Qiu Xue Cui Wei He Fang Wang Yuyao Yi Minghai Tang Zhuang Yang Yunfan Yang Zhihui Li Lijuan Chen Yiguo Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 9 | Translation of Cultural Terms Under the Functional Equivalence Theory显示文摘Different countries and different nationalities have different cultures.There are differences between them as each culture has its characteristics.Therefore,as their different value,aesthetic taste,region and custom,different cultures assign different meanings to words.According to Tytler,the translation of cultural terms should follow the three principles of translation and adopt reasonable translation methods:retention method,transference translation method,transliteration method,hybrid method,approximation method,interpretation method and implication presentation method,to overcome the translation barriers caused by cultural differences and achieve the translation effect of functional equivalence proposed by Nida. | CHEN Ying WU Huandi | 2021 | Sino-US English Teaching2021，18，10： | 0 |
| 10 | Infection and Immunity of Herpes Simplex Virusin the Culture System sof Lym phocytes and Monocyte-Macrophages显示文摘The study was made by the method of experimental infection using cultured cells in vitro. The characteristic of HSV infection of the cells and the effects of immunity factors on the infection were analyzed by cytopathic effect, double antibodies sandwich ELISA for immunoglobulin yield, hemolytic plaque assay for specific SRBC antibody forming cells, microcytopathy assay for viral titer, IFA for viral antigen and PCR for viral DNA.The results were as follows: ①A series of models of HSV infection were established, including the model of HSV 1 persistent infection of Raji cells, the model of acute and cytocidal HSV 1 infection of HSB\-2 cells, the models of temporary persistent HSV 1 infection of LPS stimulated U\-\{937\} cells and murine peritoneal macrophages and the models of inhibitions both of IgG synthesis and specific SRBC antibody production by HSV 1 infection of human tonsillar lymphocytes activated by PWM stimulating. ②According to the characteristic of HSV infection of lymphocyte and monocyte macrophage, it was reasonable that stimulating with antigen, mitogen, LPS, or inflammatory factors might make lymphocytes and/or monocyte macrophages become permissive cells of replicative HSV infection, or might activate the latent virus, resulting in HSV dissemination by blood circulation. ③It was proved that IFN α, IFN γ, TNF, M CSF, GM CSF and IL 3 have an inhibitory effect on HSV replication in lymphocyte and monocyte macrophage, respectively and reversed the replicative enhancement activity of LPS, suggesting that applications of these immunity factors favour lymphocytes and monocyte macrophages with a resistance to HSV replicative infection and with an inhibition of latent virus reactivation in vivo, and therefore, it might be helpful for preventing the virus from dissemination by blood circulation.\; | Ji Xiaohui(季晓辉) Yao Kun(姚 ) Zhou Yaoxi(周瑶玺) Zhang Ming(张 明) Wang Minglun(王明伦) Cao Zhihui(曹志惠) Sun Banghua(孙邦华) Li Huandi(李焕娣) Ding Runing(丁如宁) Chen Shenbao(陈慎宝) | 1999 | The Journal of Biomedical Research1999，23，2： | 0 |
| 11 | microRNAs regulation and its role as biomarkers in diseases显示文摘Micro RNAs(miRNAs), approximately 21 to 23 nucleotides(nt) in length, belong to a set of small non-coding RNA molecules that were not thought to be functional until the recent decades. miRNAs play important roles in many diseases such as various kinds of cancers and immune disorders. Many studies have focused on the relationship between miRNAs and diseases. miRNAs are significant mediators in human growth and development and in the genesis and development of diseases. Almost 30% of the activity of protein-coding genes is forecasted to be regulated by miRNAs in mammals, and some miRNAs are regarded as potential therapeutic targets for various diseases. In this review, we outline some functions of miRNAs, especially those related to diseases. | Huandi Zhou Xiaohui Ge Xiaoying Xue | 2016 | Oncology and Translational Medicine2016，2，1： | 0 |
| 12 | A Qualitative Study of the Triage of Patients with Non-Traumatic Acute Abdomen显示文摘Objective: To explore the work experience of medical staff in the emergency department of a general hospital in the triage of patients with non-traumatic acute abdomen to formulate corresponding intervention measures and branch evaluation tools. Methods: With descriptive phenomenology as the research method, semi-structured interviews were conducted with the medical staff in a tertiary hospital in Nanjing from February 1st to 10th, 2023, and Colaizzi seven-step analysis was used to analyze the data. Results: A total of 17 emergency medical staff were interviewed in this study. Four themes were derived from the analysis of the data: the etiology of acute abdomen is complex, so it is difficult to categorize them: acute abdomen requires immediate treatment, but the treat will be delayed if the categorization is inaccurate;the high pressure of nurses and the accuracy in categorizing the patients are problems that should be addressed. Conclusion: The categorization of patients with non-traumatic acute abdomen is challenging. Therefore, it is necessary to carry out corresponding intervention and formulate appropriate departmental evaluation tools to improve the accuracy of categorization of patients with acute abdomen. | Zhongqing Yang Juqing Ke Huandi Zhao | 2023 | Journal of Clinical and Nursing Research2023，7，4： | 0 |
| 13 | Effect of Co-substrate on Degradation of Benzothiazole in MEC显示文摘Due to its persistence and bio-toxicity,benzothiazole(BTH) cannot be biodegraded efficiently.Recent work has shown that removal rates of biorefractory organics can be enhanced by the addition of cosubstrates.In this work,ethanol,acetate,propionate and butyrate were added as co-substrates in order to promote the degradation of BTH in microbial electrolysis cell(MEC).By probing the changes in degradation rates of BTH in the presence of different co-substrates,it was observed that all the four co-substrates can enhance the BTH degradation in MEC,both the efficiency(EBTH) and the rate(RBTH).It was also found that acetate is more effective than others,which made the degradation efficiency of BTH up to 90% with acetate-C at350 mg/L(measuring by the carbon content of co-substrate,the same below),within 6 h and the degradation rate of BTH arrived 0.001 2/(mg·h).The microbacteria in MEC have also been influenced by different cosubstrates.This metabolism of the co-substrates enables the microbacteria on anode to generate ATP and thus grow to ensure the microbacteria activity.Therefore,this work showed that the addition of co-substrates such as acetate can be a novel and efficient approach for improving the elimination of BTH from wastewaters by MEC system. | Huandi Huang Jie Ding Xianshu Liu Guojun Xie Dihui Song | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，5： | 0 |
| 14 | β-catenin/LIN28B promotes the proliferation of human choriocarcinoma cells via Let-7a repression显示文摘Choriocarcinoma is a rare and malignant trophoblastic tumor.However,the molecular mechanisms by which choriocarcinoma is regulated remain unknown.In the present study,we first elucidated that LIN28B was highly expressed in human choriocarcinoma tissues and choriocarcinoma cell lines.Our data further demonstrated that knockdown of LIN28B by small interfering RNA caused an increase in Let-7a expression in JAR cells.In addition,silencing of LIN28B inhibited IGF2BP1 expression and suppressed cell proliferation capacity,both of which can be markedly restored by Let-7a inhibitor.In contrast,LIN28B over-expression-improved cell proliferation was inhibited by Let-7a mimic.Knockdown ofβ-catenin resulted in reduced expression of LIN28B and increased expression of Let-7a.Knockdown ofβ-catenin also caused a decrease in cell proliferation,which can be recovered by re-expression of LIN28B or by Let-7a inhibitor.Collectively,our data indicate thatβ-catenin/LIN28B/Let-7a pathway may be crucial for the regulation of cell proliferation in human choriocarcinoma cells. | Jing Wu Xuan Feng Yan Du Baoxin Luan Huandi Yu Yinhua Yu Lanxiang Wu Hongbo Zhao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 0 |
| 15 | TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN显示文摘We report herein that TSPAN32 is a key node factor for Philadelphia (Ph+) leukemia pathogenesis. We found that TSPAN32expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment inhibited the proliferation of Ph+cell lines. Tspan32 overexpression significantly prevented BCR-ABL induced leukemia progression in a murine model and impairedleukemia stem cell (LSC) proliferation. LSCs represent an obstacle for chronic myeloid leukemia (CML) elimination, which continuallyreplenish leukemia cells and are associated with disease relapse. Therefore, the identification of essential targets that contribute tothe survival and self-renewal of LSCs is important for novel curative CML. Mechanistically, TSPAN32 was shown to interact withPTEN, increased its protein level and caused a reduction in PI3K-AKT signaling activity. We also found that TSPAN32 was repressedby BCR-ABL via the suppression of an important transcription factor, TAL1. Ectopic expression of TAL1 significantly increasedTSPAN32 mRNA and protein level, which indicated that BCR-ABL repressed TSPAN32 transcription by decreasing TAL1 expression.Overall, we identified a new signaling axis composed of “BCR-ABL-TAL1-TSPAN32-PTEN-PI3K-AKT”. Our findings furthercomplement the known mechanisms underlying the transformation potential of BCR-ABL in CML pathogenesis. This new signalingaxis also provides a potential means to target PI3K-AKT for CML treatment. | Qiang Qiu Yuanyuan Sun Linyu Yang Qingqing Li Yunyu Feng Mengyuan Li Yuexia Yin Li Zheng Ning Li Huandi Qiu Xue Cui Wei He Bochuan Wang Cong Pan Zi Wang Juan Huang Klarke MSample Zhihui Li Yiguo Hu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 16 | The Attitude of The Times Towards China Based on Corpus显示文摘Corpus is increasingly known as a research tool,and there are more and more research fields using corpus,including some news reporting fields.As the UK’s comprehensive national circulation daily and the UK’s first mainstream newspaper,The Times is known as the“faithful recorder of British society”.It has a great impact on the world’s politics,economy,and culture.This article intercepts The Times’reports on Chinese politics,economy,science and technology,culture,and other aspects.By analyzing the theme of each report in the corpus,the reports can reflect The Times’attitude towards Chinese political,economic,cultural,and technological containment. | WU Huandi CHEN Ying | 2023 | US-China Foreign Language2023，21，1： | 0 |
| 17 | Expression of Fragaria ananassa Osmotin-like Protein(FaOLP2) in E. coli:Purification and Antifungal Activity显示文摘[Objective]The FaOLP2(Fragaria ananassa osmotin-like protein)is a functional homolog of PR5-like protein.This study was undertaken to produce recombinant FaOLP2 and to identify its antifungal activity.[Method]The ORF of FaOLP2(accession number DQ325524)was cloned into pET22b vector to construct the pET22b-FaOLP2 plasmid.The recombinant mature FaOLP2 was expressed in E.coli Rosetta-gami B(DE3)by inducing with 1 mmol/L IPTG and found exclusively in insoluble inclusion bodies.As FaOLP2 requires the correct formation of eight disulfide bonds,but there were no obvious effect to correctly form these by expression at different temperatures and high osmotic pressure(supplemented Betaineand and D-Sorbitol),we used an in vitro method to refold E.coli expressed FaOLP2 by gradually elution using reduced:oxidized gluthatione redox buffer,followed by 8 mol/L urea solubilized His6-tagged mature FaOLP2 protein,which was affinity-purified by an immobilized-metal(Ni2+)affinity chromatography(IMAC)column.[Result]This method generated biologically active conformations of the recombinant mature FaOLP2 that displayed antifungal activity against Ustilaginoides virens,a plant pathogenic fungus,which causes rice false smut.[Conclusion]This study laid the foundation for further biotechnological application of the novel protein. | Bai LI Sufang LI Huandi LI Junwei SUN Keqin ZOU | 2013 | Agricultural Biotechnology2013，2，6： | 0 |
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