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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | Molecular enhancement of porcine cardiac chronotropy 显示文摘 | Edelberg JM Huang DT Josephson ME | 2001 | Heart2001，86，5： | 1 |
| 3 | Endovenous laser treatment (EVLT) combined with surgical strategy for treatment of venous insufficiency in lower extremity: report of 208 cases 显示文摘 | Huang Y Jiang ME Lu M | 2005 | J Vase Surg2005，42，3： | 1 |
| 4 | Molecular enhancement of porcine cardiac chronotropy显示文摘 | Edelberg JM Huang DT Josephson ME | 2001 | Heart2001，86，5： | 1 |
| 5 | Parallel activationof mitochondrial oxidative metabolism with increasedcardiac energy expenditure is not dependent on fatty acidoxidation in pigs显示文摘 | Zhou L Cabrera ME Huang H | 2007 | J Physiol2007，579，3： | 1 |
| 6 | Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein 显示文摘 | Awata H Huang C Handlogten ME | 2001 | J Biol Chem2001，276，34： | 1 |
| 7 | Cardiovascular and central nervoussystem effects of intravenous levobupivacaine and bupivacaine in sheep显示文摘 | Huang YF Pryor ME Mather LE | 1998 | Anesth Analg1998，86，： | 1 |
| 8 | Molecular enhancement of porcine cardiac chronotropy显示文摘 | Edelberg JM Huang DT Josephson ME | | 0，，05： | 1 |
| 9 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 10 | Cardiaovascularand centeral nervous systeme ffectsofintravenous levobupivacaine and bupivacaine in sheep显示文摘 | Huang YF Pyror ME Mather LE | 1998 | Anesth Analg1998，86，4： | 1 |
| 11 | Indentification of a partial internal deletion in the RH locus causing the human erythroeyte D-- phenotype 显示文摘 | Huang CH Reid ME Chen Y | 1995 | Blood1995，86，2： | 1 |
| 12 | Cardiaovascular and eenteral nerv- ous system effects of intravenous levobupivacaine and bupivaeaine in sheep 显示文摘 | Huang YF Pyror ME Mather LE | 1998 | Anesth Analg1998，86，4： | 1 |
| 13 | 显示文摘 | Huang CS Anderson ME Meister A | 1993 | J Biolchem1993，268，20： | 1 |
| 14 | Rat mesangial cell hypertrophy in response to transforming growth factor-β 显示文摘 | Choi ME Kim E Huang Q | 1993 | Kidney Int1993，44，： | 1 |
| 15 | Use of all- trans retinoic acid in the treatment of acute promyelocytic leukemia 显示文摘 | Huang ME Ye YC Chen SR etal | 1998 | Blood1998，92，10： | 1 |
| 16 | Microvolt Twave altemans with exercise in pediatrics and cogenital heart disease:limitation and predictive value 显示文摘 | Alexander ME Cecchin F Huang KP | 2006 | PACE2006，29，： | 1 |
| 17 | Rat mesangial cell hypertrophy in respones to transforming growth factor-B1显示文摘 | Choi ME Kim EG Huang Q | 1993 | Kidney Int1993，44，5： | 1 |
| 18 | Molecular enhancement of porcine cardiac chronotropy 显示文摘 | Edelberg JM Huang DT Josephson ME | 2001 | Heart2001，86，5： | 1 |
| 19 | Rat mesangial cell hypertrophy in respones to transforming growth factor-betal 显示文摘 | Choi ME Kim EG Huang Q | 1993 | Kidney Int1993，44，5： | 1 |
| 20 | Copy number polymor phisms and anticancer pharmacogenomics显示文摘 | Gamazon ER Huang RS Dolan ME | 2011 | Genome Bid2011，12，5： | 1 |
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