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| 1 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 2 | Geometric optimization model for the solar cavity receiver with helical pipe at different solar radiation显示文摘In consideration of geometric parameters, several researches have already optimized the thermal efficiency of the cylindrical cavity receiver. However, most of the optimal results have been achieved at a fixed solar radiation. At different direct normal irradiance (DNI), any single optimal result may not be suitable enough for different regions over the world. This study constructed a 3-D numerical model of cylindrical cavity receiver with DNI variation. In the model of a cylindrical cavity receiver containing a helical pipe, the heat losses of the cavity and heat transfer of working medium were also taken into account. The simulation results show that for a particular DNI in the range of 400 W/m2 to 800 W/m2, there exists a best design for achieving a highest thermal efficiency of the cavity receiver. Besides, for a receiver in constant geometric parameters, the total heat losses increases dramatically with the DNI increasing in that range, as well as the temperature of the working medium. The thermal efficiency presented a different variation tendency with the heat losses, which is 2.45% as a minimum decline. In summary, this paper proposed an optimization method in the form of a bunch of fitting curves which could be applied to receiver design in different DNI regions, with comparatively appropriate thermal performances. | Chongzhe ZOU Huayi FENG Yanping ZHANG Quentin FALCOZ Cheng ZHANG Wei GAO | 2019 | Frontiers in Energy2019，13，2： | 3 |
| 3 | The influence of the metal net charge of non-metallocene early transition metal catalyst on the ethylene polymerization activity显示文摘The net charges on central metals of a serial non-metallocene early transition metal catalysts (FI catalyst) with similar steric hindrance were caculated with MM-QEq (molecular mechmism-charge equilibration) method and associated with ethylene polymerization activities of these FI catalyts. It was found that the activity increased with the net charge on metal if ignoring the influence of the steric hindrance. In other words, introduction of strong and/or more electron-withdrawing groups onto the ligand of FI catalyst would enhance the activity of the catalyst. This conculsion gave a direction to designing new FI catalyst with higher activity. | WU ChunHong LI HuaYi FENG YuQi HU YouLiang | 2008 | Chinese Science Bulletin2008，53，20： | 1 |
| 4 | Conceptual rotational mode design for optical conical scanning imaging small satellites显示文摘This paper focuses upon the novel optical conical scanning imaging working mode design for small satellites.This kind of satellite employs only one inclined optical camera achieving wide-swath imaging via a rotational motion about the nadir axis either by the camera or by the satellite.Three working modes are designed,i.e.,high-speed rotational mode,low-speed rotational mode,and variable-speed rotational mode.For the high-speed and low-speed working modes,the camera rotates at a constant speed and the corresponding angular velocity is derived under the consideration of guaranteed coverage and minimized overlap.To improve the system performance,an enhanced working mode taking advantages of both the high-speed rotational mode and lowspeed rotational mode is proposed.Working in this variable-speed rotational mode,the camera rotates slowly to get high-quality pictures when it works,while it rotates rapidly to reduce the energy consumption and save the storage during which period the camera is turned off to minimize the overlap.All these working modes are illustrated in detail,and numerical simulation tests are conducted to validate their effectiveness. | WANG Feng XI RuiChen YUE ChengFei LI HuaYi CAO XiBin | 2020 | Science China(Technological Sciences)2020，63，8： | 1 |
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