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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 4 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 5 | Effect of organic acids on aluminum toxicity in subsoils显示文摘 | Hue N V Craddock G R Adams F | 1986 | Soil Science Society of America Journal1986，50，： | 1 |
| 6 | Changes in phosphorus fractions in soils under intensive plant growth 显示文摘 | Guo F Yost R S Hue N V | 2000 | Soil Sci Soc Am J2000，64，： | 1 |
| 7 | Discrimination of fritillary ac- cording to geographical origin with Fourier transform infrared spectroscopy and two-dimensional correlation R spectroscopy 显示文摘 | Hue R Sun S Q Zhou Q | 2003 | Pharm Biomed Anal2003，33，： | 1 |
| 8 | Transpiration of natu- ral rain forest and its dependence on climatic factors 显示文摘 | Granier A Hue R Barigah T | 1996 | Agricultural and Forest Meteorology1996，78，12： | 1 |
| 9 | Once-yearly zoledronic acid for treatment of post-menopausal osteoporosis显示文摘 | Black DM Delmas PD Eastell R Reid IR Boonen S Cauley JA Cosman F Lakatos P Leung PC Man Z Mautalen C Mesenbrink P Hu H Caminis J Tong K Rosario-Jansen T Krasnow J Hue TF Sellmeyer D Eriksen EF Cummings SR HORIZON Pivotal Fracture Trial | | 0，，： | 1 |
| 10 | The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis:a randomized extension to the HORIZON-Pivotal Fracture Trial(PFT)显示文摘 | Black DM Reid IR Boonen S Bucci-Rechtweg C Cauley JA Cosman F Cummings SR Hue TF Lippuner K Lakatos P Leung PC Man Z Martinez RL Tan M Ruzycky ME Su G Eastell R | | 0，，： | 1 |
| 11 | Reduction in the risk of clinical fractures after a single dose of zoledronic Acid 5 milligrams显示文摘 | Reid IR Black DM Eastell R Bucci-Rechtweg C Su G Hue TF Mesenbrink P Lyles KW Boonen S HORIZON Pivotal Fracture Trial and HORIZON Recurrent Fracture Trial Steering Commi-ttees | | 0，，： | 1 |
| 12 | Mutation of a single residue renders human tetherin resistant to HIV- 1 Vpu-mediated depletion显示文摘 | Gupta R K Hue S Schaller T | 2009 | PloS Pathog2009，5，10： | 1 |
| 13 | Effect of organic acids on aluminum toxicity in subsoil显示文摘 | HUE N V CRADDOCK G R ADAMS F | 1986 | Soil Sci Soc Am J1986，50，： | 1 |
| 14 | Effect of organic acids on aluminum toxicity in subsoils显示文摘 | Hue N V Craddock G R Adams F | 1986 | Soil Sci Soc Am J1986，50，： | 1 |
| 15 | A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease显示文摘 | Mention J J Monteiro R C | 2004 | Immunity2004，21，3： | 1 |
| 16 | Effect of organic acids on alumlnium toxicity in subsoils显示文摘 | Hue N V Craddock G R Adams F | 1986 | Soil Sci Soc Am J1986，50，： | 1 |
| 17 | Effect of organic acids on aluminum toxicty in subsoils显示文摘 | Hue N V Craddock G R Adams F | 1986 | Soil Science Society of America Journal1986，50，： | 1 |
| 18 | Elongd Aggregates Formed by Cationic Gemini Surfactants 显示文摘 | Oda R Hue I Homo J C | 1999 | Langmuir1999，15，7： | 1 |
| 19 | Transpiration of natural rain forest and its dependence on climatic factors显示文摘 | Granier A Hue R Barigash S T | 1996 | Agricultural and Forest Meteorology1996，78，： | 1 |
| 20 | Ionic mechanisms underlying depolarizing responses of an identified insect motor neuron to short periods of hypoxia显示文摘 | Corronc H L Hue B Pitman R M | 1999 | J Neurophysiol1999，81，： | 1 |
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