|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Integrating insulin-like growth factor 1 and sex hormones into neuroprotection:Implications for diabetes显示文摘Brain integrity and cognitive aptitude are often impaired in patients with diabetes mellitus, presumably a result of the metabolic complications inherent to the disease. However, an increasing body of evidence has demonstrated the central role of insulin-like growth factor 1(IGF1) and its relation to sex hormones in many neuroprotective processes. Both male and female patients with diabetes display abnormal IGF1 and sexhormone levels but the comparison of these fluctuations is seldom a topic of interest. It is interesting to note that both IGF1 and sex hormones have the ability to regulate phosphoinositide 3-kinase-Akt and mitogen-activated protein kinases-extracellular signal-related kinasesignaling cascades in animal and cell culture models of neuroprotection. Additionally, there is considerable evidence demonstrating the neuroprotective coupling of IGF1 and estrogen. Androgens have also been implicated in many neuroprotective processes that operate on similar signaling cascades as the estrogen-IGF1 relation. Yet, androgens have not been directly linked to the brain IGF1 system and neuroprotection. Despite the sex-specific variations in brain integrity and hormone levels observed in diabetic patients, the IGF1-sex hormone relation in neuroprotection has yet to be fully substantiated in experimental models of diabetes. Taken together, there is a clear need for the comprehensive analysis of sex differences on brain integrity of diabetic patients and the relationship between IGF1 and sex hormones that may influence brain-health outcomes. As such, this review will briefly outline the basic relation of diabetes and IGF1 and its role in neuroprotection. We will also consider the findings on sex hormones and diabetes as a basis for separately analyzing males and females to identify possible hormone-induced brain abnormalities. Finally, we will introduce the neuroprotective interplay of IGF1 and estrogen and how androgen-derived neuroprotection operates through similar signaling cascades. Future research on both neuroprotection and diabetes should include androgens into the interplay of IGF1 and sex hormones. | Jacob Huffman Christina Hoffmann George T Taylor | 2017 | World Journal of Diabetes2017，8，2： | 4 |
| 2 | The TRMM Multi-satellite Precipitation Analysis (TM- PA) : Quasi-global, Multi-year, Combined-sensor precipitation at Fine Scales显示文摘 | Huffman G J Adler R F Bolvin D T | 2007 | Hydrometeorology2007，，8： | 1 |
| 3 | Management of symptoms in children with autism spectrum disorders: a comprehensive review of pharmacologic and complementary-alternative medicine treatments显示文摘 | Huffman L C Sutcliffe T L Tanner I S | 2011 | ~ Dev Behav Pediatr2011，32，1： | 1 |
| 4 | The TRMM multisatellite precipitation analysis(TMPA): Quasi-Glo- bal, multiyear, combined-sensor precipitation estimates at fine scales 显示文摘 | Huffman G J Adler R 17 Bolvin D T | 2006 | Journal of Hydrometeotology2006，7，： | 1 |
| 5 | Inactivation of bacteria,virus and Cryptosporidium by a point of use device using pulsed broad spectrum white light显示文摘 | Huffman D Slifko T Salisbury K | 2000 | Water Research (Oxford)2000，34，9： | 1 |
| 6 | Thunderstorms: An important mechanism in the transport of air pollutants 显示文摘 | Dickerson R R Huffman G J Luke W T | 1987 | Science1987，235，： | 1 |
| 7 | Fluorination of single-wall carbon nanotubes显示文摘 | Mickelson E T Huffman C B Rinzler A G | 1998 | Chem Phys Lett1998，296，1： | 1 |
| 8 | Fluorination of single-wall carbon nanotubes显示文摘 | Michelson E T Huffman C B Rinzler A G | 1998 | Chem Phys Lett1998，296，： | 1 |
| 9 | The TRMM multisatellite precipitation analysis (TMPA): Quasi-global, multiyear, combined-sensor precipitation estimates at fine scales显示文摘 | HUFFMAN G J ADLER R F BOLVIN D T | 2007 | Journal of Hydrometeorology2007，8，1： | 1 |
| 10 | Fluorinationof single-wall carbon nanotubes显示文摘 | Mickelson E T Huffman C B Rinzler A G | 1998 | Chemical Physics Letters1998，296，： | 1 |
| 11 | Radiation hardness studies of VCSELs and PINs for the optolinks of the Atlas SemiConductor Tracker显示文摘 | Chu M L Hou S Huffman T | 2007 | Nuclear Instruments & Methods in Physics Research2007，579，5： | 1 |
| 12 | Corn versus Oat Sila- ges as a Roughage for Dairy Cattle 显示文摘 | Lassiter C A Huffman C F Dexter S T | 1958 | Journal of Dairy Science1958，41，9： | 1 |
| 13 | The TRMM nmhisatellite precipitation analysis (TMPA) : Quasi-global, multi- year, combined-sensor precipitation estimates at fine scales 显示文摘 | HUFFMAN G J BOLVIN D T NELKIN E J | 2007 | Journal of Hydrometeorology2007，8，1： | 1 |
| 14 | Application of sparse nonlinear programming to trajectory optimization显示文摘 | Betts J T Huffman W P | 1992 | AIAA J of Guidance Control and Dynamics1992，15，1： | 1 |
| 15 | Individual risk attitudes: Measurement, determinants, and behavioral consequences显示文摘 | Dohmen T Falk A Huffman D | 2011 | Journal of the European Economic Association2011，9，3： | 1 |
| 16 | The TRMM multi-satellite precipitation analysis:quasi-global,multi-year,combined-sensor precipitation estimates at fine scale显示文摘 | HUFFMAN G J ADLER R F BOLVIN D T | 2007 | J Hydrometeor2007，8，1： | 1 |
| 17 | The TRMM multisatellite precipitation analysis (TMPA):Quasi-global,multiyear,combined-sensor precipitation estimates at fine scales显示文摘 | Huffman G J Adler R F Bolvin D T | | 0，，01： | 1 |
| 18 | Agricultural research expenditures in the United States:a public goods perspective显示文摘 | Khanna J Huffman W E Sandler T | 1994 | The Review of Economics and Statistics1994，，： | 1 |
| 19 | Role of Lactose in Ched- dar Cheese Manufacture and Ripening 显示文摘 | HUFFMAN L M KRISTOFFERSEN T | 1984 | New Zealand Journal of Dairy Science and Technology1984，19，2： | 1 |
| 20 | Thunder- storms: An important mechanism in the transport of air pollu- tants显示文摘 | Dickerson R R Huffman G J Luke W T | 1987 | Science1987，235，4787： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员