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| 1 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 2 | Pavement response and rutting for full scale and scaled AP'I'显示文摘 | MARTIN A E WALUBITA L F HUGO F | 2003 | Journal of Transportation Engineering2003，129，4： | 1 |
| 3 | Pavement response and rutting for full-scale and scaled APT显示文摘 | MARTIN A E WALUBITA L F HUGO F | 2003 | Journal of Transportation Engineering2003，129，4： | 1 |
| 4 | Approaches to assess the environmental impact of organic farming with particular regard to Denmark 显示文摘 | Birgitte H Hugo F A Erik S K | 2001 | Agriculture Ecosystems and Environment2001，83，1： | 1 |
| 5 | Global DNA methylation profiles of somatic embryos of peach palm (Bactris gasipaes Kunth) are influenced by cryoprotectants and droplet-vitrification cryopreservation 显示文摘 | Angelo S H Douglas A S Hugo P F F | 2013 | Plant Cell Tissue Org Cult2013，114，3： | 1 |
| 6 | Pavement response and rutting for full Scale and scaled APT显示文摘 | MARTIN A E WALUBITA L F HUGO F | 2003 | Journal of Trans- portation Engineering2003，129，4： | 1 |
| 7 | Urban air quality:the challenge of traffic non-exhaust emissions 显示文摘 | AMATO F CASSEE F R HUGO A C | 2014 | Journal of Hazardous Materials2014，275，： | 1 |
| 8 | Iron and zinc grain density in common wheat grown in Central Asia显示文摘 | Alexei M Hugo F G Aigul A | 2007 | Euphytica2007，155，： | 1 |
| 9 | Petroleum-influenced beach sediments of the Campeche Bank, Mexico: Diversity and bacterial community structure assessment显示文摘 | María C R H Hugo R S Luis F L | 2012 | Journal of Environmental Management2012，95，1： | 1 |
| 10 | Loctobocillus delbrueckii subsp lactis strain CIDCA133 inhibits nitrate re- ductase activity of Escherichia coli 显示文摘 | HUGO A A DE ANTONI G L PEREZ P F | 2006 | Interna Jour of Food Microbio2006，111，3： | 1 |
| 11 | Lactobacillus delbrueckii subsp lactis strain CIDCA 133 inhibits nitrate reduetase activity of Escherichia coli 显示文摘 | Hugo A A De Antoni C L Perez P F | 2006 | International Journal of Food Microbiology2006，111，3： | 1 |
| 12 | Pavement response and rutting for full scale and scaled APT显示文摘 | MARTIN A E WALUBITA L F HUGO F | 2003 | Journal of Transportation Engineering2003，129，4： | 1 |
| 13 | Approaches to Assess the Environmental Impact of Organic Farming With Particu- lar Regard to Denmark 显示文摘 | BIRGITTE H HUGO F A KRISTENSEN E S | 2001 | Agriculture Ecosystems & Environment2001，83，12： | 1 |
| 14 | In vivo cardiac pacemaker function of differentiated human mesenchymal stem cells from adipose tissue transplanted into porcine hearts显示文摘BACKGROUND Mesenchymal stem cells(MSC)modified by gene transfer to express cardiac pacemaker channels such as HCN2 or HCN4 were shown to elicit pacemaker function after intracardiac transplantation in experimental animal models.Human MSC derived from adipose tissue(haMSC)differentiate into cells with pacemaker properties in vitro,but little is known about their behavior after intracardiac transplantation.AIM To investigate whether haMSC elicit biological pacemaker function in vivo after transplantation into pig hearts.METHODS haMSC under native conditions(nhaMSC)or after pre-conditioning by medium differentiation(dhaMSC)(n=6 pigs each,5×106 cells/animal)were injected into the porcine left ventricular free wall.Animals receiving PBS injection served as controls(n=6).Four weeks later,total atrioventricular(AV)-block was induced by radiofrequency catheter ablation,and electronic pacemaker devices were implanted for backup stimulation and heart rate monitoring.Ventricular rate and rhythm of pigs were evaluated during a follow-up of 15 d post ablation by 12-lead-ECG with heart rate assessment,24-h continuous rate monitoring recorded by electronic pacemaker,assessment of escape recovery time,and pharmacological challenge to address catecholaminergic rate response.Finally,hearts were analyzed by histological and immunohistochemical investigations.RESULTS In vivo transplantation of dhaMSC into the left ventricular free wall of pigs elicited spontaneous and regular rhythms that were pace-mapped to ventricular injection sites(mean heart rate 72.2±3.6 bpm;n=6)after experimental total AV block.Ventricular rhythms were stably detected over a 15-d period and were sensitive to catecholaminergic stimulation(mean maximum heart rate 131.0±6.2 bpm;n=6;P<0.001).Pigs,which received nhaMSC or PBS presented significantly lower ventricular rates(mean heart rates 47.2±2.5 bpm and 37.4±3.2 bpm,respectively;n=6 each;P<0.001)and exhibited little sensitivity towards catecholaminergic stimulation(mean maximum heart rates 76.4±3.1 bpm and 60.5±3.1 bpm,respectively;n=6 each;P<0.05).Histological and immunohistochemical evaluation of hearts treated with dhaMSC revealed local clusters of transplanted cells at the injection sites that lacked macrophage or lymphocyte infiltrations or tumor formation.Intense fluorescence signals at these sites indicated membrane expression of HCN4 and other pacemaker-specific proteins involved in cardiac automaticity and impulse propagation.CONCLUSION dhaMSC transplanted into pig left ventricles sustainably induced rate-responsive ventricular pacemaker activity after in vivo engraftment for four weeks.The data suggest that pre-conditioned MSC may further differentiate along a pacemakerrelated lineage after myocardial integration and may establish superior pacemaker properties in vivo. | Fabrice F Darche Rasmus Rivinius Ann-Kathrin Rahm Eva Köllensperger Uwe Leimer Günter Germann Miriam Reiss Michael Koenen Hugo A Katus Dierk Thomas Patrick A Schweizer | 2020 | World Journal of Stem Cells2020，12，10： | 0 |
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