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| 1 | Mechanism of intrauterine infection of hepatitis B virus显示文摘AIM:To explore the possible mechanism of intrauterine infection of hepatitis B virus (HBV).METHODS: HBV DNA was detected in vaginal secretion and amniotic fluid from 59 HBsAg-positive mothers and in venous blood of their newborns by PCR. HBsAg and HBcAg in placenta were determined by ABC immunohistochemistry.RESULTS:The rate of HBV intrauterine infection was 40.1% (24/59). HBV DNA was detected in 47.5% of amniotic fluid samples and 52.5% of vaginal secretion samples respectively.HBsAg and HBcAg were detected in placentas from HBsAg-positive mothers. The concentration of the two antigens decreased from the mother's side to the fetus's side, in the following order:maternal decidual cells>trophoblastic cells> villous mesenchymal cells>villous capillary endothelial cells. However, in 4 placentas the distribution was in the reverse order. HBsAg and HBcAg were detected in amniotic epithelial cells from 32 mothers.CONCLUSION:The main route of HBV transmission from mother to fetus is transplacental, from the mother side of placenta to the fetus side. However, HBV intrauterine infection may take place through other routes. | Shu-LinZhang Ya-FeiYue Gui-QinBai LeiShi HuiJiang | 2004 | World Journal of Gastroenterology2004，10，3： | 48 |
| 2 | Prevalence and risk factors of erectile dysfunction in three cities of China: a community-based study显示文摘Aim:To determine the age-adjusted prevalence of erectile dysfunction (ED) in 3 big cities of China and to explore its potential sociodemographic, medical and lifestyle correlates. Methods: A crosssectional, population-based survey was conducted in three cities of China. Structured questionnaires were administered to 2 226 men, aged 20-86 years, by trained interviewers. Results: The age-adjusted prevalence of ED was 28.34% (mild 15.99%,moderate 7.14%, severe 5.21%). In the men above 40, the prevalence was 40.2%. Age was positively correlated with ED (P<0.01). Education was negatively correlated with ED (P<0.01). Spouse companionship, living condition were positively correlated with ED (P<0.01). Histories of cardiovascular disease, diabetes, and hyperlipidemia were positively correlated with ED (P<0.01). Cigarette smoking was not correlated with ED (P>0.05), while the cigaretteconsumption and duration were positively correlated with ED (P<0.01). Alcohol drinking is negatively correlated with ED (P<0.01). The duration of drinking was positively correlated with ED (P<0.01). Weekly alcohol consumption was not correlated with ED (P>0.05). Conclusion: The prevalence of ED increased with age. Cardiovascular disease, diabetes and hyperlipidemia were positively correlated with the increased prevalence. Sociodemographic and lifestyle factors, such as education, spouse companionship, living condition, cigarette and alcohol consumption or duration also have association with the prevalence of ED. (Asian J Androl 2004 Dec;6:343-348) | QuanBai Qing-QuanXu HuiJiang Wei-LiZhang Xing-HuanWang Ji-ChuanZhu | 2004 | Asian Journal of Andrology2004，6，4： | 25 |
| 3 | Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation显示文摘Aim: To assess the psychometric properties of the Chinese Index of Premature Ejaculation (CIPE).Methods: The sexual function of 167 patients with and 114 normal controls without premature ejaculation (PE) were evaluated with CIPE. All subjects were married and had regular sexual activity. The CIPE has 10 questions, focusing on libido, erectile function, ejaculatory latency, sexual satisfaction and difficulty in delaying ejaculation, self-confidence and depression. Each question was responded to on a 5 point Likert-type scale. The individual question score and the total scale score were analyzed between the two groups. Results: There were no significant differences between the age, duration of marriage and educational level (P>0.05) of patients with and without PE and normal controls. The mean latency of patients with PE and normal controls were 1.6±1.2 and 10.2±9.5 minutes,respectively. Significant differences between patients with (26.7±4.6) PE and normal controls (41.9±4.0) were observed on the total score of CIPE (P<0.01). Using binary logistic regression analysis, PE was significantly related to five questions of the original measure. They are the so-called the CIPE-5 and include: ejaculatory latency, sexual satisfaction of patients and sexual partner, difficulty in delaying ejaculation, anxiety and depression. Receiver Operating Characteristic (ROC) curve analysis of CIPE-5 questionnaire indicated that the sensitivity and specificity of CIPEwere 97.60% and 94.74%, respectively. Employing the total score of CIPE-5, patients with PE could be divided intothree groups: mild (>15 point) 19.8%, moderate (10~14 point) 62.8% and severe (<9point) 16.7%. Conclusion:The CIPE-5 is a useful method for the evaluation of sexual function of patients with PE and can be used as a clinical endpoint for clinical trials studying the efficacy of pharmacological intervention. | Yi-MingYuan Zhong-ChengXin HuiJiang Yan-JieGuo Wu-JiangLiu LongTian Ji-ChuanZhu | 2004 | Asian Journal of Andrology2004，6，2： | 21 |
| 4 | Method of accurate grinding for single enveloping TI worm显示文摘TI worm drive consists of involute helical gear and its enveloping Hourglass worm. Accurate grinding for TI worm is the key manufacture technology for TI worm gearing being popularized and applied.According to the theory of gear mesh, the equations of tooth surface of worm drive are gained, and the equation of the axial section profile of grinding wheel that can accurately grind TI worm is extracted. Simultaneously, the relation of position and motion between TI worm and grinding wheel are expounded. The method for precisely grinding single enveloping TI worm is obtained. | SUN Yuehai ZHENG Huijiang BI Qingzhen WANG Shuren | 2005 | Science China(Technological Sciences)2005，48，4： | 5 |
| 5 | Genome wide association study identifies SNPs associated with fatty acid composition in Chinese Wagyu cattle显示文摘Background: Fatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the genetic mechanism underpinning these traits and promote the improvement of fatty acid profiles. In this study, we performed a genome-wide association study(GWAS) on fatty acid composition using high-density single nucleotide polymorphism(SNP) arrays in Chinese Wagyu cattle.Results: In total, we detected 15 and 8 significant genome-wide SNPs for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, respectively. Also, we identified nine candidate genes based on 100 kb regions around associated SNPs. Four SNPs significantly associated with C14:1 cis-9 were embedded with stearoyl-CoA desaturase(SCD), while three SNPs in total were identified for C22:6 n-3 within Phospholipid scramblase family member 5(PLSCR5), Cytoplasmic linker associated protein 1(CLASP1), and Chymosin(CYM). Notably, we found the top candidate SNP within SCD can explain ~ 7.37% of phenotypic variance for C14:1 cis-9.Moreover, we detected several blocks with high LD in the 100 kb region around SCD. In addition, we found three significant SNPs within a 100 kb region showing pleiotropic effects related to multiple FA groups(PUFA,n-6, and PUFA/SFA), which contains BAI1 associated protein 2 like 2(BAIAP2 L2), MAF bZIP transcription factor F(MAFF),and transmembrane protein 184 B(TMEM184 B).Conclusions: Our study identified several significant SNPs and candidate genes for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, and these findings will further assist the design of breeding programs for meat quality in cattle. | Zezhao Wang Bo Zhu Hong Niu Wengang Zhang Ling Xu Lei Xu Yan Chen Lupei Zhang Xue Gao Huijiang Gao Shengli Zhang Lingyang Xu Junya Li | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 6 | CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma:a cross-talk between FGF21 and the NRF2 pathway显示文摘The treatment of hepatocellular carcinoma(HCC)has been dominated by multikinase inhibitors for more than a decade.However,drug resistance can severely restrict the efficacy of these drugs.Using CRISPR/CAS9 genome library screening,we evaluated Kelch-like ECH-associated protein 1(KEAP1)as a key regulator of sorafenib’s susceptibility in HCC.We also investigated whether KEAP1’s knockdown can stabilize nuclear factor(erythroid-derived 2)-like 2(NRF2)protein levels that led to sorafenib’s resistance,including an NRF2 inhibitor that can synergize with sorafenib to abolish HCC’s growth in vitro and in vivo.Furthermore,we clarified that fibroblast growth factor 21(FGF21)is an important downstream regulator of NRF2 in HCC.Intriguingly,we observed that FGF21 bound to NRF2 through the C-terminus of FGF21,thereby stabilizing NRF2 by reducing its ubiquitination and generating a positive feedback loop in sorafenib-resistant HCC.These findings,therefore,propose that targeting FGF21 is a promising strategy to combat HCC sorafenib’s resistance. | Jiang Chen Shi Jiang Huijiang Shao Bixia Li Tong Ji Daniel Staiculescu Jiayan He Jie Zhao Liuxin Cai Xiao Liang Junjie Xu Xiujun Cai | 2022 | Science China(Life Sciences)2022，65，10： | 4 |
| 7 | Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum显示文摘 | JingLinKONG XiuBaoDU ChongXuFAN YingCAO HuiJIANG JianFuXU XiaoJunZHENG | 2004 | Chinese Chemical Letters2004，15，11： | 2 |
| 8 | Modified particle swarm optimization algorithm for variable selection in MLR and PLS modeling: QSAR studies of antagonism of angiotensin II antagonists 显示文摘 | Qi Shen Jian Huijiang Chen Xujiao | 2004 | European Journal of Pharmaceutical Sciences (S0928-0987)2004，22，23： | 1 |
| 9 | Optimal Decay Estimates on the Linearized Boltzmann Equation with Time Dependent Force and their Applications显示文摘 | Renjun Duan Seiji Ukai Tong Yang Huijiang Zhao | 2008 | Communications in Mathematical Physics2008，，1： | 1 |
| 10 | Global Existence of Classical Solutions to the Vlasov-Poisson-Boltzmann System显示文摘 | Tong Yang Huijiang Zhao | 2006 | Communications in Mathematical Physics2006，，3： | 1 |
| 11 | Cauchy Problem for the Vlasov–Poisson–Boltzmann System显示文摘 | Tong Yang Hongjun Yu Huijiang Zhao | 2006 | Archive for Rational Mechanics and Analysis2006，，3： | 1 |
| 12 | Convergence Rate to Stationary Solutions for Boltzmann Equation with External Force显示文摘为有在在空格变量的一个潜在的函数的坡度形式的外部力量的 Boltzmann 方程,它的静止解决方案的稳定性被 S 作为 localMaxwellians 学习。Ukai 等。(2005 ) 通过精力方法。在分析集中率到可压缩的海军司烧方程的静止解决方案上把稳定性分析和一些技术基于这,在这篇论文,我们学习集中率到是在为非平衡的统计物理的一个基本方程的 Boltzmann 方程的上述静止解决方案使精的气体。由通过庆祝 H 定理在非液体部件上在液体部件和驱散上从粘性和热电导率联合驱散,象为 compressibleNavier 司烧的那的一样的顺序的集中率被构造某精力 functionals 获得。 | Seiji UKAI Tong YANG Huijiang ZHAO | 2006 | Chinese Annals of Mathematics,Series B2006，27，4： | 1 |
| 13 | Statistical mod- els for jointly analyzing multiple allometries显示文摘 | Gao Huijiang Liu Yongxin Zhang Tingting | 2013 | Journal of Theo- retical Biology2013，318，： | 1 |
| 14 | Composite interval mapping of QTL for dynamic traits显示文摘Many economically important quantita- tive traits in animals and plants are measured re- peatedly over time. These traits are called dynamic traits. Mapping QTL controlling the phenotypic pro- files of dynamic traits has become an interesting topic for animal and plant breeders. However, statistical methods of QTL mapping for dynamic traits have not been well developed. We develop a composite in- terval mapping approach to detecting QTL for dy- namic traits. We fit the profile of each QTL effect with Legendre polynomials. Parameter estimation and statistical test are performed on the regression coefficients of the polynomials under the maximum likelihood framework. Maximum likelihood estimates of QTL parameters are obtained via the EM algorithm. Results of simulation study showed that composite interval mapping can improve both the statistcial power of QTL detecting and the accuracy of parameter estimation relative to the simply interval mapping procedure where only one QTL is fit to each model. The method is developed in the context of an F2 mapping population, but extension to other types of mapping populations is straightforward. | GAO Huijiang YANG Runqing | 2006 | Chinese Science Bulletin2006，51，15： | 1 |
| 15 | Shape- controlled production of biodegradable calcium alginate gel microparticles using a novel microfluidic device 显示文摘 | Liu Kan Ding Huijiang Liu Jing | 2006 | Langmuir2006，22，22： | 1 |
| 16 | Microstructure and electric properties of strontium lanthanum niobate显示文摘 | Fu Chunlin Liu Huijiang Chen Gang | 2012 | Ferroelectrics2012，，： | 1 |
| 17 | Electrochemical Biosensing for Cancer Cells Based on TiO<sub>2</sub>/CNT Nanocomposites Modified Electrodes显示文摘 | QinShen Sun‐KyungYou Soo‐GilPark HuiJiang DadongGuo BaoanChen XuemeiWang | 2008 | Electroanalysis2008，，23： | 1 |
| 18 | Global smooth solutions for a class of guasilinear hyprebolic systems with dissipative terms显示文摘 | Yang Tong Zhu Changjiang Zhao Huijiang | 1997 | Proc Roy Soc Edinburgh1997，127，： | 1 |
| 19 | Relay scheduling for cooperative communications in sensor networks with energy harves-ting显示文摘 | Li Huijiang Jaggi N?Sikdar B | 2011 | IEEE Transactions on Wireless Communications2011，10，9： | 1 |
| 20 | Relay scheduling for cooperative communications in sensor networks with energy harvesting显示文摘 | Li Huijiang Jaggi N Sikdar B | 2011 | IEEE Transactions on Wireless Communications2011，10，9： | 1 |
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