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| 1 | A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy显示文摘在这研究,联网的可胀大的糊精 nanogel (DNG ) 被开发完成刺激应答的小介入为黑瘤肿瘤的 RNA (siRNA ) 版本治疗。siRNA 被费用冷凝作用装进多维的糊精 nanogels,积极精氨酸残余在糊精脊梁修改了。而且,联网的 nanogel 被破坏并且基于它的 bioreducible 松开了应答的性质在 bioreducible 控制加速的 siRNA 版本细胞内部的环境,当它在正常生理的条件下面仍然保持稳定时。我们由传播电子显微镜学评估在减少的缓冲区状况下面表明了可胀大的有的那 DNG 和拆卸性质。DNG 完成了被触发谷胱甘肽的拆卸货物的选择版本根据共焦的显微镜学观察跟随进 cytosol 的 endosomal 逃跑。因此,这聪明的 nanogel 完成了突出的酶基因 silencing 效率并且减少在 vitro 并且在 vivo 的 Bcl2 蛋白质表示基于西方的污点分析。而且,这 nanogel 在 C57BL/6 老鼠为 B16F10 异种皮移植肿瘤展出了优异反肿瘤活动。这些结果证明联网的 DNG 为基因冷凝作用是有效的并且为肿瘤治疗控制细胞内部的版本。总的来说,这些调查结果建议这多维的可胀大的刺激应答的糊精 nanogel 是有为基因和药交货的大诺言的创新策略。 | Huipeng Li Zhanwei Zhou Feiran Zhang Yuxin Guo Xue Yang Hulin Jiang Fei Tan David Oupicky Minjie Sun | 2018 | Nano Research2018，11，9： | 1 |
| 2 | A β-cyclodextrin covalent organic framework used as a chiral stationary phase for chiral separation in gas chromatography显示文摘Chiral covalent organic frameworks(CCOFs) featuring chirality, stability, and good porosity have attracted a considerable amount of attention due to their important applications, such as asymmetric catalysis, chiral separation, and chiral recognition. In this study, a β-cyclodextrin(β-CD) covalent organic framework(β-CD-COF) diluted with polysiloxane OV-1701 was explored as a novel chiral stationary phase(CSP) for gas chromatography(GC) separation of racemates. The β-CD-COF coated capillary column had excellent selectivity, not only for the separation of linear alkanes, linear alcohols, fatty acid methyl esters mixture, the Grob mixture and positional isomers, but also for the resolution of chiral compounds, including chiral alcohols, aldehydes, ethers, and amino acid derivatives. In addition, the β-CD-COF-coated capillary column presented good repeatability and reproducibility. This work indicated the great potential of the CCOFs coated capillary column for the chromatographic separation of enantiomers. | Bo Tang Wei Wang Huipeng Hou Yiquan Liu Zongkun Liu Lina Geng Liquan Sun Aiqin Luo | 2022 | Chinese Chemical Letters2022，33，2： | 1 |
| 3 | Visualization of nasal powder distribution using biomimetic human nasal cavity model显示文摘Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity.However,no reliable method is currently available to assess its impact on delivery performance.In this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal cavity.The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females.The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test.The experimental device produced the most satisfactory results with five spray times.Furthermore,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,respectively.Additionally,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo correlation.In conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution. | Jiawen Su Yan Liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen Wang Zeru Li Jianhua Lu Lulu Wang Xiaofeng Wang Jie Wu Lixin Sun Jiwen Zhang Zhigang Wang Rui Yang Li Wu | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 4 | Application of 'Three-in-One' Strategy Based on MOF-199 in Determination of Phenylenediamine Isomers and Cr(Ⅵ)显示文摘Industry progressing caused the pollutants into the surface and groundwater,including organic pollutants such as phenylenediamine(PD)and heavy metals such as Cr(Ⅵ).Herein,a simple'three-in-one'strategy based on MOF-199 was demonstrated.The MOF-199 catalytic system could be used for the rapid detection of Cr(Ⅵ)and o-phenylenediamine(OPD)in linear ranges of 0.5-50.0μmol/L and 7.0-250.0μmol/L,with the limits of detection of 0.1 and 0.5μmol/L,respectively.This method can also efficiently discriminate PD isomers in just 15 min.Meanwhile,Cr(Ⅵ)was reduced to Cr(Ⅲ)and the elimination of OPD was carried out.Given simple synthesis,high sensitivity,easy operation,and low cost,this method presented a potential platform for on-site detection of pollutants in water samples. | Yueci Xiang Jiantao Wei Huipeng Sun Ruiyi Zhao Zehua Han Shuangtong Wu Xiaoyan Liu Haixia Zhang | 2024 | Journal of Analysis and Testing2024，8，1： | 0 |
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