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| 1 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 2 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 3 | Octreotide protects against hepatic ischemia/ reperfusion injury via HO-l-mediated autophagy显示文摘 | Shuangfa Zou Huiping Sun Keith A. Candiotti Yanhua Peng Qinya Zhang Weiqiang Xiao Shuwu Zhao Liqiang Wu Jinfeng Yang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 3 |
| 4 | Ataxia,acute mountain sickness,and high altitude cerebral edema显示文摘Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in acute mountain sickness(AMS)and HACE among mountain rescuers on the quake areas,and in approaching the relation between AMS and HACE. After the earthquake on April 14,2010,approximately 24 080 lowland rescuers were rapidly transported from sea level or lowlands to the mountainous rescue sites at 3 750 ~ 4 568 m,and extremely hardly worked for an emergency treatment after arrival. Assessments of acute altitude illness on the quake areas were using the Lake Louise Scoring System. 73 % of the rescuers were found to be developed AMS. The incidence of high altitude pulmonary edema(HAPE)and HACE was 0.73 % and 0.26 %,respectively,on the second to third day at altitude. Ataxia sign was measured by simple tests of coordination including a modified Romberg test. The clinical features of 62 patients with HACE were analyzed. It was found that the most frequent,serious neurological symptoms and signs were altered mental status(50/62,80.6 %)and truncal ataxia(47/62,75.8 %). Mental status change was rated slightly higher than ataxia,but ataxia occurred earlier than mental status change and other symptoms. The earliest sign of ataxia was a vague unsteadiness of gait,which may be present alone in association with or without AMS. Advanced ataxia was correlated with the AMS scores,but mild ataxia did not correlate with AMS scores at altitudes of 3 750~4 568 m. Of them,14 patients were further examined by computerized tomographic scanning of the brain and cerebral magnetic resonance imagines were examined in another 15 cases. These imaging studies indicated that the presence of the cerebral edema was in 97 % of cases who were clinically diagnosed as HACE(28/29). Ataxia seems to be a reliable sign of advanced AMS or HACE,so does altered mental status. | Wu Tianyi Ma Siqing Bian Huiping Zhang Minming | 2013 | Engineering Sciences2013，11，2： | 3 |
| 5 | Detection of Thermophysical Properties for High Strength Concrete after Exposure to High Temperature显示文摘Using the detection principle of infrared thermal imaging technique and the detection principle of DRH thermal conductivity tester laboratory,we investigated the infrared thermal image inspection,coefficient of thermal conductivity,apparent density,and compressive strength test on C80 high-strength concrete(HSC) in the presence and absence of polypropylene fibers under completely heated conditions.Only slight damages were detected below 400 ℃,whereas more and more severe deterioration events were expected when the temperature was above 500 ℃.The results show that the elevated temperature through infrared images generally exhibits an upward trend with increasing temperature,while the coefficient of thermal conductivity and apparent density decrease gradually.Additionally,the addition of polypropylene fibers with appropriate length,diameter,and quantity contributes to the improvement of the high-temperature resistance of HSC. | 杜红秀 WU Jia LIU Gaili WU Huiping YAN Ruizhen | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，1： | 3 |
| 6 | Microbial community variation in phytoremediation of triazophos by Canna indica Linn. in a hydroponic system显示文摘Phytoremediation of triazophos (O,O-diethyl-O-(1-phenyl-1,2,4-triazole-3-base) sulfur phosphate, TAP) pollution by Canna indica Linn. in a hydroponic system has been well studied, whereas the microbial mechanism on TAP degradation is still unknown. The variation in microbial community compositions was investigated by analyzing phospholipid fatty acids (PLFAs) profiles in microbes under TAP exposure. The TAP exposure resulted in an increase in proportions of fatty acid 16:0 and decrease in fatty acid 18:2ω9,12c, indicating that TAP may stimulate the reproduction of microorganisms and inhibit the growth of fungi to some degree. Significant correlation was found between the ratio of fungi to bacteria and TAP removal (r 2 = 0.840, p < 0.01). In addition, the microbial community in the phytoremediation system with C. indica was dominated by Gram negative bacteria, which possibly contributed to the degradation of TAP. These results indicated that TAP might induce the colonization of bacteria in the hydroponic system planted with C. indica, and lead to a discrimination of microbial community, which might be one of the mechanisms on TAP dissipation in phytoremediation system. | Huiping Xiao Shuiping Cheng Zhenbin Wu | 2010 | Journal of Environmental Sciences2010，22，8： | 3 |
| 7 | A Review on Electric Vehicle Charging Infrastructure Development in the UK显示文摘This paper focuses on the development of electric vehicle(EV)charging infrastructure in the UK,which is a vital part of the delivering ultra-low-emission vehicle(ULEV)and will transition into low emission energy systems in the near future.Following a brief introduction to global landscape of EV and its infrastructure,this paper presents the EV development in the UK.It then unveils the government policy in recent years,charging equipment protocols or standards,and existing EV charging facilities.Circuit topologies of charging infrastructure are reviewed.Next,three important factors to be considered in a typical site,i.e.,design,location and cost,are discussed in detail.Furthermore,the management and operation of charging infrastructure including different types of business models are summarized.Last but not least,challenges and future trends are discussed. | Tianjin Chen Xiao-Ping Zhang Jianji Wang Jianing Li Cong Wu Mingzhu Hu Huiping Bian | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，2： | 3 |
| 8 | Studies on monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome secondary to high altitude pulmonary edema显示文摘To study monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome (ARDS) secondary to high altitude pulmonary edema (HAPE),we performed clinic and laboratory studies in 8 patients who preliminarily developed high altitude cerebral edema (HACE) and then ARDS occurred at an altitude of 4 500 m. After an initial emergency treatment on high mountains,all the patients were rapidly transported to a hospital at a lower altitude of 2 808 m. The right cardiac catheterizations were carried out within 5 h after hospitalized. The monitoring hemodynamics and oxygen dynamics were studied via a thermodilution Swan-Gaze catheter. The results showed that before treatments at the beginning of monitoring,there presented a significant pulmonary artery hypertension with a decreased cardiac function,and a lower oxygen metabolism in all the 8 patients. However,after some effective treatments,including mechanical ventilation and using dexamethasone,furosemide,etc,four days later the result of a repeated monitoring showed that their pulmonary artery pressure had been decreased with an improved cardiac function with all the oxygen metabolic indexes increased significantly. Our studies suggested that performing monitoring hemodynamics in patients with ARDS secondary to HAPE will define the clinical therapeutic measures which will benefit the outcome. | Ma Siqing Wu Tianyi Cheng Qiang Li Pei Bian Huiping | 2013 | Engineering Sciences2013，11，2： | 2 |
| 9 | A comparison on the phytoremediation ability of triazophos by different macrophytes显示文摘The strategy of choosing suitable plants should receive great performance in phytoremediation of surface water polluted by triazophos(O,O-diethyl-O-(1-phenyl-1,2,4-triazol-3-base) sulfur phosphate, TAP), which is an organophosphorus pesticide widespread applied for agriculture in China and moderately toxic to higher animal and fish. The tolerance, uptake, transformation and removal of TAP by twelve species of macrophytes were examined in a hydroponic system and a comprehensive score(CS) of five parameters(relative growth rate(RGR), biomass, root/shoot ratio, removal capacity(RC), and bio-concentration factor(BCF)) by factor analysis was employed to screen the potential macrophyte species for TAP phytoremediation. The results showed that Thalia dealbata, Cyperus alternifolius, Canna indica and Acorus calamus had higher RGR values, indicating these four species having stronger growth capacity under TAP stress. The higher RC loading in Iris pseudacorus and Cyperus rotundus were 42.11 and 24.63 μg/(g fw·day), respectively. The highest values of BCF occurred in A. calamus(1.17), and TF occurred in Eichhornia crassipes(2.14). Biomass and root/shoot ratio of plant showed significant positive correlation with first-order kinetic constant of TAP removal in the hydroponic system, indicating that plant biomass and root system play important roles in remediation of TAP. Five plant species including C. alternifolius, A. calamus, T. dealbata, C. indica and Typha orientalis, which owned higher CS, would be potential species for TAP phytoremediation of contaminated water bodies. | Zhu Li Huiping Xiao Shuiping Cheng Liping Zhang Xiaolong Xie Zhenbin Wu | 2014 | Journal of Environmental Sciences2014，26，2： | 2 |
| 10 | Combining Spot4-vegetation and meteorological data derived land cover map in China显示文摘 | Wu Bingfang Xu Wenting Huang Huiping | 2004 | IEEE International Geoscience and Remote Sensing Symposium Proceedings2004，4，： | 1 |
| 11 | Multifractal analysis of Hang Seng index in Hong Kong stock market显示文摘 | Sun Xia Chen Huiping Wu Ziqin | 2001 | Physica A2001，，291： | 1 |
| 12 | Muhifractal Analysis of Hang Seng Index in Hong Kong Stock Market 显示文摘 | Xia Sun Huiping Chen Ziqin Wu Yongzhuang Yuan | 2001 | Physica A2001，，291： | 1 |
| 13 | Experi- mental study on carboxymethyl chitosan in preventing peritoneal adhesion in rats显示文摘 | Zhang Ziping Zhou Guangwen Wu Huiping | 2000 | J Clin Res Jun2000，27，6： | 1 |
| 14 | Predictability of multifractal analysis of Hang Seng stock index in Hong Kong显示文摘 | Xia Sun Huiping Chen Ziqin Wu Yongzhuang Yuan | 2001 | Physica A2001，301，： | 1 |
| 15 | Multifractal analysis of Hang Seng stock index in Hong Kong stock market显示文摘 | Xia Sun Huiping Chen Ziqin Wu Yongzhuang Yuan | 2001 | Physica A2001，291，： | 1 |
| 16 | Multifractal analysis of Hang Seng index in Hong Kong stock market 显示文摘 | Xia Sun Huiping Chen Ziqin Wu | 2001 | Physica A2001，291，： | 1 |
| 17 | Multifractal analysis of Hang Seng index in Hong Kong stock market显示文摘 | SUN Xia CHEN Huiping WU Ziqin | | 0，，291： | 1 |
| 18 | Efficient meshfree formulation for metal forming simulation显示文摘 | YOON S P WU C T WANG Huiping | 2001 | Jounal of Engineering Materials and Technology2001，123，4： | 1 |
| 19 | Multifractal analysis of Heng Seng index in Hong Kong stock market显示文摘 | SUN Xia CHEN Huiping WU Ziqin YUAN Yongzhuang | 2001 | Physica A2001，291，： | 1 |
| 20 | Idiopathic IgA nephropathy with diffuse crescent formation显示文摘 | Tang Zheng Wu Yan Cheng Huiping | 2002 | Am J Nephrol2002，22，56： | 1 |
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