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| 1 | A successful mountain rescue operation in Yushu Earthquake显示文摘On April 14,2010,an earthquake reaching 7.1 Richter scale struck Jiegu Town of Yushu.More than 2 698 people were confirmed dead,and 12 135 were injured,of which 1 434 were severely injured.Rescue operation was carried out soon after the disaster;however,the rescue teams face great challenges of altitude hypoxia,freezing temperature and very bad weather.Thus,1 434 severe injuries were rapidly transported airlifted to hospitals in Xining and neighboring provinces for effective treatment.The extremity trauma (49.9 %) was the most common pattern of injuries.Asphyxia (40.8 %) was by far the most important reason for death.A high incidence of acute altitude illness in the lowland rescuers was a special medical problem during the highest earthquake in Yushu.We have learned more lessons from Yushu Earthquake. | Wu Tianyi Li Suzhi Hou Shike Ouzhu Luobu | 2012 | Engineering Sciences2012，10，1： | 15 |
| 2 | IRESfinder:Identifying RNA internal ribosome entry site in eukaryotic cell using framed k-mer features显示文摘In eukaryotic cells,initiation of protein translation is to recruit the ribosome to a specific mRNA,which is generally dependent on the 5'cap structure.However,protein translation can also be initiated in a cap-independent manner by using a cis-regulatory element termed the internal ribosome entry site(IRES).The first experimentally validated IRES was reported in the | Jian Zhao Jing Wu Tianyi Xu Qichang Yang Junhao He Xiaofeng Song | 2018 | Journal of Genetics and Genomics2018，45，7： | 14 |
| 3 | 30-W supercontinuum generation based on ZBLAN fiber in an all-fiber configuration显示文摘We report an all-fiberized 30-W supercontinuum(SC) generation in a piece of ZrF4-BaF2-LaF3-AlF3-NaF(ZBLAN) fiber. The pump source is a thulium-doped fiber amplifier(TDFA) with broadband output spectrum spanning the 1.9 to 2.6 μm region. The used ZBLAN fiber has a core diameter of 10 μm, and was directly fusion-spliced to the pigtail of the TDFA without using a traditional mode field adapter(MFA) or a piece of transition fiber. Such a low-loss and robust fusion splice joint, together with a robust AlF3-fiber-based endcap,enables efficient and high-power SC generation in the ZBLAN fiber. An SC with an average power up to 30.0 W and a spectral coverage of 1.9–3.35 μm with 20-dB bandwidth of 1.92–3.20 μm was obtained. Moreover, an SC with a broader spectrum was achieved by raising the pump pulse peak power(via reducing the duty ratio of the pump laser pulse). An SC with an output power of 27.4 W and a spectral coverage of 1.9–3.63 μm(with 20-dB bandwidth of 1.92–3.47 μm) was obtained, as well as an SC with output power of 24.8 W and a spectral coverage of 1.9–3.70 μm(with 20-dB bandwidth of 1.93–3.56 μm). The power conversion efficiency was measured as>69%. To the best of the authors’ knowledge, this research demonstrates the record output power of SC lasers based on ZBLAN fibers, paving the way for broadband and efficient multi-tens-of-watts SC generation in softglass fibers. | LINYONG YANG YING LI BIN ZHANG TIANYI WU YIJUN ZHAO JING HOU | 2019 | Photonics Research2019，7，9： | 9 |
| 4 | Medical mountain rescue in the Yushu Earthquake: Have lessons been learned?显示文摘On April 14,2010,an earthquake reaching Richter scale 7.1 struck Jiegu Town of Yushu,a mountain rescue operation promptly launched. All injurers had a direct assess to take medical care,and were immediately rescued and rapidly evacuated by air to Xining and Golmud at lower altitudes and admitted to advanced hospitals. Almost all of the injurers have been completely recovered. Yushu Earthquake was one of the highest earthquakes in the world,with a high incidence of acute altitude illness,which was observed in about 80 % of the lowland rescuers at an altitude of 4 000 m.'Rescue the rescuers'became the major task of Qinghai-Tibetan rescue teams,all the severe patients were rapidly descended to Xining and treated promptly and effectively. The outcome was excellent,all patients survived. After the earthquake,it is a long and arduous task to reconstruct what has been destroyed. Medical teams continue to work in the Yushu Earthquake area because about 30 000 workers and carders are now here for rebuilding the earthquake center. Thus the prevention and treatment of altitude illness are still critical tasks for medical teams. Although all the fights are successful,there are more experiences and lessons we have learned from the medical mountain rescue during the earthquake and the reconstruction,and reports here are to sum up our experiences from the medical mountain rescue operation in Yushu Earthquake and draw the lessons that we should learn. With the increasing of earthquake probability occurring in the Qinghai-Tibetan Plateau,we also should prepare against earthquake disasters and for further rescue training in the high mountains. | Wu Tianyi | 2013 | Engineering Sciences2013，11，2： | 7 |
| 5 | Noise-sidebands-free and ultra-low-RIN 1.5 μm single-frequency fiber laser towards coherent optical detection显示文摘A noise-sidebands-free and ultra-low relative intensity noise(RIN) 1.5 μm single-frequency fiber laser is demonstrated for the first time to our best knowledge. Utilizing a self-injection locking framework and a booster optical amplifier, the noise sidebands with relative amplitudes as high as 20 dB are completely suppressed.The RIN is remarkably reduced by more than 64 dB at the relaxation oscillation peak to retain below-150 dB∕Hz in a frequency range from 75 kHz to 50 MHz, while the quantum noise limit is -152.9 d B∕Hz.Furthermore, a laser linewidth narrower than 600 Hz, a polarization-extinction ratio of more than 23 dB, and an optical signal-to-noise ratio of more than 73 dB are acquired simultaneously. This noise-sidebands-free and ultralow-RIN single-frequency fiber laser is highly competitive in advanced coherent light detection fields including coherent Doppler wind lidar, high-speed coherent optical communication, and precise absolute distance coherent measurement. | QILAI ZHAO ZHITAO ZHANG BO WU TIANYI TAN CHANGSHENG YANG JIULIN GAN HUIHUI CHENG ZHOUMING FENG MINGYING PENG ZHONGMIN YANG SHANHUI XU | 2018 | Photonics Research2018，6，4： | 7 |
| 6 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 7 | Rapid detection of pesticide residues in Chinese herbal medicines by molecularly imprinted membrane electrospray ionization mass spectrometry显示文摘Chinese herbal medicines(CHMs)play an increasingly important role in the field of medicine and affects public health in the world.Although more and more strict has been employed to ensure the quality and safety of CHMs,pesticide residues in CHMs remain a serious issue and are the bottleneck for the global development of CHMs.In this work,we applied molecularly imprinted membrane electrospray mass spectrometry(MIM-ESI MS)for rapid detecting 4 classes of pesticide residues in CHMs,including organophosphorus(OPP),carbamates,pyrethroids and neonicotinoids in CHMs.Compared with our previous ambient ionization method MESI,MIM-ESI is capable of achieving a~50-fold increase in the detection limit of conventional analytical methods owing to the specificity recognition and unique enrichment of MIM.The optimal experimental conditions were determined,and the method was further validated for its sensitivity and specificity.Our data showed that MIM-ESI MS is applicable for the direct quantitation of pesticide residues in CHMs.This detection technology may help to ensure the quality of CHMs in the future. | Chunmei Wu Tianyi Li Dongju Li Shanshan Jia Jianmei Huang Haimin Lei Mei Zhang | 2021 | Chinese Chemical Letters2021，32，7： | 6 |
| 8 | In situ calcite U-Pb geochronology by high-sensitivity single-collector LA-SF-ICP-MS显示文摘U-Pb geochronology of calcite using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) is an emerging method,with potential applications to a vast array of geological problems.Due to the low levels of U and Pb in calcite,measurement using higher-sensitivity instruments,such as sector field (SF) ICP-MS,have advantages over more commonly used quadrupole (Q) ICP-MS instruments.Using a Thermo Element XR ICP-MS,we demonstrate that the Jet+X cone combination with the N_(2) enhancement technique provides the best sensitivity for measuring U and Pb isotopes.This higher sensitivity improves the precision of calcite U-Pb isotope measurements,and permits dating at high spatial resolutions (<110μm) and for samples containing low contents of^(238)U (<1μg g^(–1)) and/or^(207)Pb (i.e.,young samples<10 Ma).Using a spot size of 85μm with a low fluence (~2.0 J cm^(–2)),the laser-induced elemental fractionation of^(206)Pb/^(238)U in the NIST SRM 614,ARM-3 and WC-1 reference materials are insignificant (<2.2%).Adopting the optimized instrument parameters,we analysed four commonly-used calcite U-Pb reference materials (WC-1,Duff Brown Tank,JT,and ASH-15).The results match well with published isotope dilution data,demonstrating the reliability of our technique.ARM-3,an andesitic glass,is shown to be an appropriate reference material for both^(207)Pb/^(206)Pb calibration and instrument optimization because of its moderate contents of U(~3.75μg g^(–1)) and Pb (~12.7μg g^(–1)).We further demonstrate that the image-guided approach using LA-ICP-MS elemental mapping is an efficient tool in obtaining robust ages. | Shitou WU Yueheng YANG Nick M.W.ROBERTS Ming YANG Hao WANG Zhongwu LAN Bohang XIE Tianyi LI Lei XU Chao HUANG Liewen XIE Jinhui YANG Fuyuan WU | 2022 | Science China Earth Sciences2022，65，6： | 6 |
| 9 | S100A8 promotes epithelial-mesenchymal transition and metastasis under TGF-β/USF2 axis in colorectal cancer显示文摘Background:The transforming growth factor-β(TGF-β)pathway plays a pivotal role in inducing epithelial-mesenchymal transition(EMT),which is a key step in cancer invasion and metastasis.However,the regulatory mechanism of TGF-βin inducing EMT in colorectal cancer(CRC)has not been fully elucidated.In previous studies,it was found that S100A8 may regulate EMT.This study aimed to clarify the role of S100A8 in TGF-β-induced EMT and explore the underlying mechanism in CRC.Methods:S100A8 and upstream transcription factor 2(USF2)expression was detected by immunohistochemistry in 412 CRC tissues.Kaplan-Meier survival analysis was performed.In vitro,Western blot,and migration and invasion assays were performed to investigate the effects of S100A8 and USF2 on TGF-β-induced EMT.Mouse metastasis models were used to determine in vivo metastasis ability.Luciferase reporter and chromatin immunoprecipitation assay were used to explore the role of USF2 on S100A8 transcription.Results:During TGF-β-induced EMT in CRC cells,S100A8 and the transcription factor USF2 were upregulated.S100A8 promoted cell migration and invasion and EMT.USF2 transcriptionally regulated S100A8 expression by directly binding to its promoter region.Furthermore,TGF-βenhanced the USF2/S100A8 signaling axis of CRC cells whereas extracellular S100A8 inhibited the USF2/S100A8 axis of CRC cells.S100A8 expression in tumor cells was associated with poor overall survival in CRC.USF2 expression was positively related to S100A8 expression in tumor cells but negatively related to S100A8-positive stromal cells.Conclusions:TGF-βwas found to promote EMT and metastasis through the USF2/S100A8 axis in CRC while extracellular S100A8 suppressed the USF2/S100A8 axis.USF2 was identified as an important switch on the intracellular and extracellular S100A8 feedback loop. | Si Li Jun Zhang Senmi Qian Xuesong Wu Liang Sun Tianyi Ling Yao Jin Wenxiao Li Lichao Sun Maode Lai Fangying Xu | 2021 | Cancer Communications2021，41，2： | 5 |
| 10 | Ascent schedules,acute altitude illness,and altitude acclimatization:Observations on the Yushu Earthquake显示文摘During the Yushu Earthquake on April 14,2010,a large number of rescuers from sea level or lowlands ascended to the quake areas very rapidly or rapidly less than 24 h. However,Yushu Earthquake is the highest quake in the world at altitudes between 3 750 m and 4 878 m where is a serious hypoxic environment. A high incidence of acute altitude illness was found in the unacclimatized rescuers;the mountain rescue operation changed as 'rescue the rescuers'. Lesson from the Yushu Earthquake is that the occurrence of acute altitude illness may be closely related to the ascent schedules. This prompted us to study the relationship between ascent rate and the incidence and severity of acute altitude illness;five different groups were compared. The first group was 42 sea level male young soldiers who ascended to quake area very rapidly within 8 h at 4 000 m;the second group was 48 sea level male young soldiers who ascended to 4 000 m rapidly less than 18 h;the third group was 66 acclimatized medical workers from 2 261 m who ascended to 4 000 m rapidly within 12 h;the fourth group was 56 Tibetan medical workers from 2 800 m who ascended to 4 000 m rapidly within 8 h;the fifth group was 50 male sea level workers who ascended to 4 000 m gradually over a period of 4 d. The results showed that the sea level rescuers ascended to 4 000 m very rapidly or rapidly had the highest incidence of acute mountain sickness (AMS) with the greatest AMS scores and the lowest arterial oxygen saturation (SaO2);the sea level workers ascended to 4 000 m gradually had moderate incidence of AMS with moderate AMS scores and SaO2 values;whereas the acclimatized and adapted rescuers had the lowest incidence of AMS,lowest AMS scores and higher SaO2;especially none AMS occurred in Tibetan rescuers. AMS score is inversely related to the ascent rate (r=-0.24,p< 0.001). Additionally,acute altitude illness is significantly influenced by altitude acclimatization. The ascent rate is inversely re- lated to the period of altitude acclimatization whereas the time of perfect recovered from AMS is positively correlated to the time taken to acclimatize. Generally,the best means of preventing acute altitude illness is slow and gradual ascent to high altitude,as this allows time for establishing altitude acclimatization and tolerance to the hypoxic environment. However,during an emergency circumstance,such as mountain rescue operation,the rescuers must rapidly ascend to high altitude,so a series of preventive strategies including pre-acclimatization,using some prophylactic drugs and oxygen supplementary are sorely necessary. | Wu Tianyi Hou Shike Li Shuzhi Li Wenxiang Gen Deng | 2013 | Engineering Sciences2013，11，2： | 5 |
| 11 | Integrating deep learning to achieve phase compensation for free-space orbital-angular-momentum-encoded quantum key distribution under atmospheric turbulence显示文摘A high-dimensional quantum key distribution(QKD), which adopts degrees of freedom of the orbital angular momentum(OAM) states, is beneficial to realize secure and high-speed QKD. However, the helical phase of a vortex beam that carries OAM is sensitive to the atmospheric turbulence and easily distorted. In this paper, an adaptive compensation method using deep learning technology is developed to improve the performance of OAM-encoded QKD schemes. A convolutional neural network model is first trained to learn the mapping relationship of intensity profiles of inputs and the turbulent phase, and such mapping is used as feedback to control a spatial light modulator to generate a phase screen to correct the distorted vortex beam. Then an OAM-encoded QKD scheme with the capability of real-time phase correction is designed, in which the compensation module only needs to extract the intensity distributions of the Gaussian probe beam and thus ensures that the information encoded on OAM states would not be eavesdropped. The results show that our method can efficiently improve the mode purity of the encoded OAM states and extend the secure distance for the involved QKD protocols in the free-space channel, which is not limited to any specific QKD protocol. | XINGYU WANG TIANYI WU CHEN DONG HAONAN ZHU ZHUODAN ZHU SHANGHONG ZHAO | 2021 | Photonics Research2021，9，2： | 5 |
| 12 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 13 | Spectrally flat supercontinuum generation in a holmium-doped ZBLAN fiber with record power ratio beyond 3μm显示文摘A spectrally flat mid-infrared supercontinuum(MIR-SC) spanning 2.8–3.9 μm with a maximum output power of 411 mW was generated in a holmium-doped ZBLAN fiber amplifier(HDZFA). A broadband fiber-based SC covering the 2.4–3.2 μm region was designed to seed the amplifier. Benefiting from the broadband seed laser,the obtained SC had a high spectral flatness of 3 dB over the range of 2.93–3.70 μm(770 nm). A spectral integral showed that the SC power beyond 3 μm was 372 mW, i.e., a power ratio of 90.6% of the total power. This paper,to the best of our knowledge, not only demonstrates the first spectrally flat MIR-SC directly generated in fluoride fiber amplifiers, but also reports the highest power ratio beyond 3 μm obtained in rare-earth-doped fluoride fiber until now. | LINYONG YANG BIN ZHANG KE YIN TIANYI Wu YIJUN ZHAO JING Hou | 2018 | Photonics Research2018，6，5： | 4 |
| 14 | Online Teaching for Elementary and Secondary Schools During COVID-19显示文摘This report draws on data from two articles published by the Center for Teacher Education Research of Beijing Normal University,namely,“Survey Report on the Status Quo of Online Teaching and Related Needs Among Elementary and Secondary Schools During COVID-19 Prevention and Control:Based on a Sample Survey on School Principals in China”and“Survey Report on the Status Quo of Online Teaching and Related Needs Among Elementary and Secondary School Teachers During COVID-19 Prevention and Control:Based on a Sample Survey on Teachers in China.” | Huan Song Jianjian Wu Tianyi Zhi | 2020 | ECNU Review of Education2020，3，4： | 3 |
| 15 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 16 | Ataxia,acute mountain sickness,and high altitude cerebral edema显示文摘Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in acute mountain sickness(AMS)and HACE among mountain rescuers on the quake areas,and in approaching the relation between AMS and HACE. After the earthquake on April 14,2010,approximately 24 080 lowland rescuers were rapidly transported from sea level or lowlands to the mountainous rescue sites at 3 750 ~ 4 568 m,and extremely hardly worked for an emergency treatment after arrival. Assessments of acute altitude illness on the quake areas were using the Lake Louise Scoring System. 73 % of the rescuers were found to be developed AMS. The incidence of high altitude pulmonary edema(HAPE)and HACE was 0.73 % and 0.26 %,respectively,on the second to third day at altitude. Ataxia sign was measured by simple tests of coordination including a modified Romberg test. The clinical features of 62 patients with HACE were analyzed. It was found that the most frequent,serious neurological symptoms and signs were altered mental status(50/62,80.6 %)and truncal ataxia(47/62,75.8 %). Mental status change was rated slightly higher than ataxia,but ataxia occurred earlier than mental status change and other symptoms. The earliest sign of ataxia was a vague unsteadiness of gait,which may be present alone in association with or without AMS. Advanced ataxia was correlated with the AMS scores,but mild ataxia did not correlate with AMS scores at altitudes of 3 750~4 568 m. Of them,14 patients were further examined by computerized tomographic scanning of the brain and cerebral magnetic resonance imagines were examined in another 15 cases. These imaging studies indicated that the presence of the cerebral edema was in 97 % of cases who were clinically diagnosed as HACE(28/29). Ataxia seems to be a reliable sign of advanced AMS or HACE,so does altered mental status. | Wu Tianyi Ma Siqing Bian Huiping Zhang Minming | 2013 | Engineering Sciences2013，11，2： | 3 |
| 17 | Enhancing the mechanical and anticorrosion properties of 316L stainless steel via a cathodic plasma electrolytic nitriding treatment with added PEG显示文摘A cathodic plasma electrolytic nitriding(CPEN)treatment with a urea aqueous solution was performed on 316L stainless steel to rapidly improve its surface properties in this work.Test results show that the PEG2000 macromolecules increased the nitriding energy via enhancing the ability to bond the produced gas film to the metal/electrolyte interface.The cross-sectional morphologies indicate that a thick nitrided layer was obtained when the urea concentration was 543 g I^-1,corresponding to a Vickers hardness 450 HV(0.1),which was 3.5 times larger than that of the substrate.The nitrided layer mainly contained expanded austenite(γN),oxides and iron nitrides(e.g.,Fe3O4 and FeN(0.076)).In terms of its performance,coefficient of friction(COF)of the nitride layer decreased to nearly two-thirds that of the untreated layer,and the passivation current densities of the nitrided sample in a 3.5%NaCl solution decreased by an order of magnitude compared to that of the substrate.Therefore,the approach presented herein provides an attractive way to modify the effect of CPEN in a urea aqueous solution. | Tianyi Zhang Junsheng Wu Lei Jin Zhan Zhang Wan Rong Bowei Zhang Yi Wang Yedong He Wei Liu Xiaogang Li | 2019 | Journal of Materials Science & Technology2019，35，11： | 3 |
| 18 | Low-overpotential electrochemical ammonia synthesis using BiOCl-modified 2D titanium carbide MXene显示文摘Electrochemical synthesis of ammonia has the advantages of low energy consumption and promising environmental protection,as compared to the traditional Haber-Bosch process.However,the commercial utilization of this novel system is limited by the low Faradaic efficiency,poor ammonia yield and high overpotential due to the strong NN bond and the dominant competing reaction of hydrogen evolution reaction(HER).Herein,a BiOCl-modified two-dimensional(2D)titanium carbide MXenes nanocomposite(BiOCl@Ti_(3)C_(2)T_(x))is proposed as a promising electrocatalyst for ambient nitrogen(N_(2))reduction reaction with excellent catalytic performance and superior long-term stability at low overpotential.In 0.1 mol/L HCl,this catalyst attains a high Faradic efficiency of 11.98%and a NH_(3)yield of 4.06μg h^(-1)cm^(-2)at-0.10 V(vs.RHE),benefiting from its strong interaction of Bi 6p band with the N 2p orbitals,combined with its large specific surface area and the facile electron transfer. | Yu Wang Munkhbayar Batmunkh Hui Mao Hui Li Baohua Jia Shuyao Wu Daliang Liu Ximing Song Ying Sun Tianyi Ma | 2022 | Chinese Chemical Letters2022，33，1： | 2 |
| 19 | Carbon Fiber Supported Binary Metal Sulfide Catalysts with Multi-Dimensional Structures for Electrocatalytic Nitrogen Reduction Reactions Over a Wide pH Range显示文摘Green and environmentally friendly electrocatalytic nitrogen(N_(2))fixation to synthesize ammonia(NH3)is recognized as an effective method to replace the traditional Haber-Bosch process.However,the difficulties in N_(2) adsorption and fracture of hard N≡N bond still remain major challenges in electrocatalytic N_(2) reduction reactions(NRR).From the perspectives of enhancing N_(2) adsorption and providing more catalytic sites,two-dimensional(2D)FeS_(2) nanosheets and three-dimensional(3D)metal organic framework-derived ZnS embedded within N-doped carbon polyhedras are grown on the carbon cloth(CC)template in this work.Thus,a composite NRR catalyst with multi-dimensional structures,which is signed as FeS_(2)/ZnS-NC@CC,is obtained for using over a wide pH range.The uniform distribution of hollow ZnS-NC frameworks and FeS_(2) nanosheets on the surface of CC largely increase the N_(2) enrichment efficiency and offer more active sites,while the CC skeleton acts as an independent conductive substrate and S-doping helps promote the fracture of N≡N bond during the NRR reaction.As a result,the FeS_(2)/ZnS-NC@CC electrode achieves a high Faraday efficiency of 46.84%and NH3 yield of 58.52μg h^(−1) mg^(−1) at-0.5 V vs.Ag/AgCl in 0.1 M KOH.Furthermore,the FeS_(2)/ZnS-NC@CC electrode displays excellent NRR catalytic activity in acidic and neutral electrolytes as well,which outperforms most previously reported electrocatalysts including noble metals.Therefore,this work provides a new way for the design of multi-dimensional electrocatalysts with excellent electrocatalytic efficiency and stability for NRR applications. | Tianyi Zhang Wei Zong Yue Ouyang Yue Wu Yue-E Miao Tianxi Liu | 2021 | Advanced Fiber Materials2021，3，4： | 2 |
| 20 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
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