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| 1 | Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis显示文摘AIM:To investigate Toll-like receptor(TLR)signaling regulators in microscopic and ulcerative colitis patients.METHODS:Total RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls and patients with active or in-remission collagenous colitis(CC),lymphocytic colitis(LC),or ulcerative colitis(UC).We compared expressions of interleukin-1receptor-associated kinase(IRAK)-2,IRAK-M,interleukin(IL)-37,microRNA(miR)-146a,miR-155,and miR-21 using quantitative real time reverse transcription polymerase chain reaction.RESULTS:IRAK-M expression was increased in LC patients with active disease in histopathological remission(LC-HR;P=0.02)and UC patients(P=0.01),but no differences in IRAK-2 expression were detected compared to controls.miR-146a,-155 and-21 expressions were increased in LC-HR(P=0.04,0.07,and 0.004)and UC(P=0.02,0.04 and 0.03)patients.miR-146a and miR-21 expressions were significantly enhanced in UC patients compared to UC remission(UC-R;P=0.01and 0.04).Likewise,active CC patients showed significantly increased expression of miR-155(P=0.003)and miR-21(P=0.006).IL-37 expression was decreased in both CC(P=0.03)and LC(P=0.04)patients with a similar trend in UC patients but not statistically significant,whilst it was increased in UC-R patients compared to controls(P=0.02)and active UC(P=0.001).CONCLUSION:The identification of differentially expressed miRNAs,IL-37,and IRAK-M suggests different pathophysiologic mechanisms in various disease stages in LC,CC,and UC. | Sezin Gunaltay Nils Nyhlin Ashok Kumar Kumawat Curt Tysk Johan Bohr Olof Hultgren Elisabeth Hultgren Hornquist | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis显示文摘One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation(FMT) in active collagenous colitis(CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC. | Sezin Günaltay Lech Rademacher Elisabeth Hultgren Hornquist Johan Bohr | 2017 | World Journal of Gastroenterology2017，23，7： | 4 |
| 3 | Multiple pathways allow protein secretion across the bacterial outer membrane显示文摘 | Thanassi DG Hultgren SJ | 2000 | Curr Opin Cell Biol2000，12，4： | 1 |
| 4 | Predictive value of the P wave at implantation for atrial fibrillation after VVI packer implantation显示文摘 | Sheltigar U Barry W Hultgren H | 1992 | PACE1992，15，： | 1 |
| 5 | T-helper and humoral responses to Puumala hantavirus nucleocapsid protein : identification of Thelper epitopes in a mouse model 显示文摘 | Nicacio CC Sallberg M Hultgren C | 2001 | J Gen Virol2001，82，： | 1 |
| 6 | Leptin in septic arthritis:decreased levels during infection and amelioration of disease activity upon its administra tion显示文摘 | Hultgren OH Tarkowski A | 2001 | Arthritis Res2001，3，： | 1 |
| 7 | Pilus and nonpilus bacterial adhesins:assembly and function in cell recognition显示文摘 | Hultgren S J Abraham S Caparon M | | 0，，5： | 1 |
| 8 | Structural biology of the chaperone- usher pathway of pilus biogenesis 显示文摘 | Waksman G Hultgren S J | 2009 | Nat Rev Microbiol2009，7，11： | 1 |
| 9 | High altitude pulmonary edema: hemodynamic aspects显示文摘 | Hultgren HN | 1997 | Int J Sports Med1997，18，： | 1 |
| 10 | Left ventricular function at high altitude examined by systolic time intervals and M - mode echocardiography显示文摘 | Fowles RE Hultgren HN | 1983 | Am J Cardiol1983，52，： | 1 |
| 11 | Morbidity in 3-7 month-old dairy calves in south-western Sweden,and risk factors for diarrhea and respiratory disease显示文摘 | Svensson C Hultgren J Oltenacu PA | 2006 | Prev Vet Med2006，74，： | 1 |
| 12 | Structure and function of Escherichia coli type 1 pili:new insight into the pathogenesis of urinary tract infections显示文摘 | SCHILLING J D MATTHEW S HULTGREN J | 2001 | Infect Dis2001，，： | 1 |
| 13 | A murine model of urinar-ytxact infection显示文摘 | Hung CS Dodson KW Hultgren SJ | 2009 | Nature Protocols2009，4，8： | 1 |
| 14 | A murine model of urinarytract infection 显示文摘 | Hung CS Dodson KW Hultgren SJ | 2009 | Nat Protoc2009，4，8： | 1 |
| 15 | A study of research on children's information behaviour in a school context显示文摘 | HULTGREN F LOUISE L | 2003 | New Review of Information Behaviour Research2003，4，1： | 1 |
| 16 | Structure and function of Escherichia coli type 1 pili:new insight into the pathogenesis of urinary tract infections显示文摘 | Schilling J D Mulvy M A Hultgren S | 2001 | J Infect Dis2001，183，1： | 1 |
| 17 | Microscopic colitis patients have increased proportions of Ki67 + proliferating and CD45RO + active/memory CD8 + and CD4 + 8 + mucosal T cells显示文摘 | Ashok Kumar Kumawat Hilja Strid Kristina Elgbratt Curt Tysk Johan Bohr Elisabeth Hultgren H?rnquist | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 18 | Building rapport with customers across the world:The global diffusion of a call center speech style显示文摘 | Anna Kristina Hultgren | | 0，，： | 1 |
| 19 | The impactsof climate change in coastal marine systems显示文摘 | Harley C D G Hughes A R Hultgren K M | 2006 | EcolLett2006，9，： | 1 |
| 20 | Induction of type I diabetes by interferon-alpha in transgenic mice 显示文摘 | Stewart TA Hultgren B Huang X et ai | 1993 | Science1993，260，5116： | 1 |
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