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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Buffering in optical packet switches显示文摘 | D K Hunter M C Chia I Andonovic | 1998 | IEEE Journal of Lightwave Technology1998，16，12： | 2 |
| 3 | 基于影像表现预测骨关节炎进展显示文摘目前常用X线检查评估骨关节炎(OA)进展,MRI可了解OA初期至晚期关节功能丧失阶段进展规律。最新研究表明,MRI检测到的关节结构异常变化,如软骨缺损和骨髓水肿增加,软骨体积和厚度减少,软骨成分改变等可用于评估OA进展。肥胖、肌肉萎缩、关节内外翻、代谢性疾病、炎症和关节疼痛等临床危险因素及软骨损伤、骨髓水肿、半月板病变、滑膜炎等影像学特征等关节结构因素均与OA进展有关。改善这类危险因素,可减缓疾病进展;利用MRI监测疾病进展,发现新的危险因素,并对危险因素进行干预,有助于阻断OA进展。对处于高危险因素人群进行临床试验研究,可减少试验样本量和随访时间,增强临床试验研究效率。该文主要介绍OA进展的最新流行病学和临床研究证据,以及与OA进展相关的危险因素。 | 徐勤光 韦宋谱 王学宗 丁道芳 庞坚 郑昱新 曹月龙 詹红生 Ding C Zhang Y Hunter D | 2013 | 国际骨科学杂志2013，34，2： | 2 |
| 4 | A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration显示文摘 | Hadlock T Sundback C Hunter D | | 0，，： | 2 |
| 5 | The apparent, of polyphenol oxidase and phloridzin in the production of apple rooting cofactors显示文摘 | Bassuk N L Hunter L D Howard B H | 1981 | J Hort Sci1981，56，4： | 1 |
| 6 | Distribution of volcanic sediments in the Golf coastal Province-significance to petroleum geology显示文摘 | Davis D K | 1979 | Transactions Golf Coast Association of Geological Societies1979，29，1： | 1 |
| 7 | Partial discharge monitoring for power transformers using UHF sensors, part 1 : sensors and signal interpretation显示文摘 | Judd M D Yang L Hunter B B | 2005 | IEEE Electrical Insulation Magazine2005，21，2： | 1 |
| 8 | Cytokine gene expression patterns associated with immunization against Mareks disease in chickens 显示文摘 | ABDUL-CAREEM M F HUNTER B D PARVIZI P | 2007 | Vaccine2007，25，3： | 1 |
| 9 | Long persistent light emitting diode 显示文摘 | JIA D HUNTER D N | 2006 | Journal of Applied Physics2006，100，11： | 1 |
| 10 | An improved closed -form approximation to the inverse black body radiation problem at microwave frequencies显示文摘 | HUNTER J D | 1986 | IEEE Trans Antennas Propagat1986，34，： | 1 |
| 11 | Dietary fiber intake and risk of colorectal cancer:a pooled analysis of prospective cohort studies显示文摘 | PARK Y HUNTER D J SPIEGELMAN D | 2005 | JAMA2005，294，： | 1 |
| 12 | Acute heat stress-induced alterations in blood Acid-based status and skeletal muscle membrane in broiler chickens at two ages: implications for meat quality显示文摘 | Sandercock D A Hunter R R Nute G R | 2001 | Poultry Science2001，80，： | 1 |
| 13 | Nylon-6 Nano- composites from Alkylammonium-modified Clay: The Role of Alkyl Tails on Exfoliation 显示文摘 | FORNES T D HUNTER D L PAUL D R | 2004 | Macromolecules2004，37，5： | 1 |
| 14 | 查看详情显示文摘 | Hunter A P Games D E | | 0，，07： | 1 |
| 15 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 16 | Host responses are induced in feathers of chickens infected with Marek's disease virus显示文摘 | Abdul-Careem M F Hunter B D Sarson A J | 2008 | Virology2008，370，2： | 1 |
| 17 | Lumbar facet joint osteoarthritis: A review显示文摘 | Kaliehman L Hunter D | 2007 | Semin Arthritis Rheum2007，37，1： | 1 |
| 18 | Measurement of cerebral blood volume with subtraction three-dimensional functional CT显示文摘 | Hunter GJ Kierstead D | 1996 | AJNR Am J Neuroradiol1996，17，： | 1 |
| 19 | Measurement of retinal vessel widths from fundus images based on 2D modeling 显示文摘 | LOWELL J A HUNTER A STEEL D | 2004 | IEEE Transactions on Medical Imaging2004，23，10： | 1 |
| 20 | Prevalence of prostatitis like symptoms in a population based study using the National Institutes of Health Chronic Prostatitis Symptom Index 显示文摘 | Nickel JC Downey J Hunter D | 2001 | J Urol2001，165，： | 1 |
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