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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Numerical index of the discriminatory ability of typing systems : an application of Simpson' s index of diversity显示文摘 | Hunter P R Gaston M A | 1988 | Clin Microbiol1988，26，： | 1 |
| 3 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 4 | An agonist antibody specific for CD40 induces dendritic cell maturation and promotes autologous anti-tumour T-cell responses in an in vitro mixed autologous tumour cell/lymph node ceU model 显示文摘 | Hunter T B Alsarraj M Gladue R P | 2007 | Scand J Immunol2007，65，5： | 1 |
| 5 | 显示文摘 | M Nevier W R Hunter | 1980 | Applied Optics1980，19，12： | 1 |
| 6 | The inhibitors of apoptosis (IAPs) as cancer targets显示文摘 | Hunter A M LaCasse E C Korneluk R G | 2007 | Apoptosis2007，12，9： | 1 |
| 7 | CART peptides显示文摘 | Kuhar M J Adams L D Hunter R G Vechia S D Smith Y | 2000 | Regul Pept2000，89，13： | 1 |
| 8 | Listening to the Customers Using QFD 显示文摘 | Hunter M R | 1994 | Quality Progress1994，27，4： | 1 |
| 9 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 10 | Dual-waveband operation of a multilayer-coated diffraction grating in the soft X-ray range at near-normal incidence显示文摘 | M P Kowalski J F Seely W R Hunter | 1993 | Applied Optics1993，32，13： | 1 |
| 11 | Sperm viability and sperm competition in insects显示文摘 | HUNTER F M BIRKHEAD T R | 2002 | Current Biology2002，12，： | 1 |
| 12 | Chronic nitrogen deposition alters the structure and function of detrital food webs in a northern hardwood ecosystem 显示文摘 | Gan H Zak D R Hunter M D | 2013 | Ecological Applications2013，23，6： | 1 |
| 13 | Probability Judgment and Subadditivity: The role of Working Memory Capacity and Constraining Retrieval显示文摘 | Dougherty M R Hunter J E | 2003 | Memory & Cognition2003，31，6： | 1 |
| 14 | Trans-acting siRNA- mediated repression of ETI'IN and ARF4 regulates heteroblasty in Arabidopsis显示文摘 | I Hunter C Willmann M R Wu G et ol | 2006 | Development2006，133，15： | 1 |
| 15 | Thiolsulfinate allicin from gar-lic: inspiration for a new antimicrobial agent 显示文摘 | Hunter R Caira M Stellenboom N | 2005 | Ann N Y Acad Sci2005，，1056： | 1 |
| 16 | Endocrine and paracrine control of follicular development and ovulation rate in farm species显示文摘 | HUNTER M G ROBINSON R S MANN G E | 2004 | Anim Reprod Sci2004，，8283： | 1 |
| 17 | Characterization of fractionated atrial electrograms critical for maintenance of atrial fibrillation:a randomized,controlled trial of ablation strategies (the CFAE AF Trial)显示文摘 | Hunter R J Diab I Tayebjee M | | 0，，5： | 1 |
| 18 | Examining Ni- laterite leach mineralogy & chemistry-a holistic multi-scale approach 显示文摘 | Hunter H M A Herrington R J Anne O E | 2013 | Minerals Engineering2013，54，： | 1 |
| 19 | The solubility of various gases in Fischer-Tropsch reactor wax 显示文摘 | van Nuren D S Hunter J R Heydenrych M D | 1988 | Chem Eng Sci1988，43，6： | 1 |
| 20 | Numerical index of the discriminatory ability of typing systems:an application of Simpson's index of diversity显示文摘 | Hunter P R Gaston M A | 1988 | J Clin Microbiol1988，26，11： | 1 |
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