|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Escherichia coli iron superoxide dismutase targeted to the mitochondria of yeast ceils protects the cells against oxidative stress 显示文摘 | Balzan R Bannister W H Hunter G J | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 3 | 显示文摘 | M Nevier W R Hunter | 1980 | Applied Optics1980，19，12： | 1 |
| 4 | Vitamin E biosynthesis : functional characterization of the monocot homogentisate geranylgeranyl transferase 显示文摘 | Yang W Y Cahoon R E Hunter S C | 2011 | The Plant Journal2011，65，： | 1 |
| 5 | Molecular cloning and nucleotide sequence of the alphatoxin (phospholipase c) of Clostridium perfringens 显示文摘 | HUNTER S E C MARTIN K L | 1989 | Infect Immun1989，57，2： | 1 |
| 6 | Dual-waveband operation of a multilayer-coated diffraction grating in the soft X-ray range at near-normal incidence显示文摘 | M P Kowalski J F Seely W R Hunter | 1993 | Applied Optics1993，32，13： | 1 |
| 7 | Optical properties of evaporated iridium in the vacuum ultraviolet from 500 Angstroms to 2000 Angstroms显示文摘 | HASS G JACOBUS G F HUNTER W R | 1967 | JOSA1967，57，6： | 1 |
| 8 | Thrombosed synthetic hemodialysis access fistulas: failure of fibrinolytic therapy 显示文摘 | Young A T Hunter D W Castaneda Zuniga W R | 1985 | Radiology1985，154，3： | 1 |
| 9 | CART: fromgeneto function显示文摘 | Adams L D Gong W Vechia S D Hunter R G Kuhar M J | 1999 | BrainRes1999，848，12： | 1 |
| 10 | Theme Article-Processing and Properties of Polymers Modified by Clays显示文摘 | Douglas L Hunter Karl W Kamena Paul D R | 2007 | MRS Bull2007，82，： | 1 |
| 11 | Scrambling properties of optical fibers and the performance of a double scambler显示文摘 | Todd R Hunter Lawrence W Ramsey | 1992 | Pubilcations of the Astronomical Society of the Pacific1992，104，682： | 1 |
| 12 | Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place prerence显示文摘 | Kimmel H L Gong W Vechia S D Hunter R G Kuhar M J | 2000 | J Pharma col Exp Ther2000，294，： | 1 |
| 13 | Molecular cloning and nucleotide sequence of the alphatoxin of Clostridium perfrigens 显示文摘 | Tithall R W Hunter S E C Martin K L | 1989 | Infection and Immunity1989，57，2： | 1 |
| 14 | Parenteral selenium and vitamin E supplementation of weaned beef calves显示文摘 | Swecker W S J K H Hunter R K Shanklin | 2008 | J Vet Intern Med2008，22，2： | 1 |
| 15 | Thermal degradation chemistry of alkyl quaternary ammonium montmorillonite显示文摘 | XIE W GAO Z M PAN W P HUNTER D SINGH A VAIA R | 2001 | Chemistry of Materials2001，13，9： | 1 |
| 16 | The effects of polarizer elliptieity on ellipsometry measurements 显示文摘 | W R Hunter D Eaton C Sah | 1970 | Surface Sci1970，20，2： | 1 |
| 17 | Fractal cracking of concrete: parameterization of spatial diffusion显示文摘 | Addison P S McKenzie W M C Ndumu A S Dougan L T Hunter R | 1999 | Journal of Engineering Mechanics1999，125，6： | 1 |
| 18 | Zonula occludens-1 alters eonnexin43 gap junction size and organization by influencing channel accretion 显示文摘 | HUNTER A W BARKER R J ZHU C | 2005 | Molecular Biology of the Cell2005，16，12： | 1 |
| 19 | Effect of particle size distribution and aggregation on electroacoustic measurments of ζ potential显示文摘 | James M Hunter R J O'Brien R W | 1992 | Langmuir1992，8，： | 1 |
| 20 | Scrambling proper- ties of optical fibers and the performance of a double scrambler显示文摘 | HUNTER T R RAMSEY L W | 1992 | Astronomical Society of the Pacific1992，104，682： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员