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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | 精神病病人和服用精神类药物病人接受和长期接受阿片类药物治疗:国家级商业保险索赔研究显示文摘越来越多的证据表明,美国的阿片类处方正遵循一种'逆向选择'模式,这种模式使得接受阿片类药物长期治疗的病人更可能处于阿片类药物不良反应的最大风险中,特别是那些物质使用障碍(SUD)和其他精神病病人。本研究调查了10311961位填写阿片类处方病人的医疗保险索赔情况,特别比较了患精神病及行为异常(比如阿片类和非阿片类SUD、自杀倾向或自残行为、机动车事故、抑郁症、焦虑症和睡眠障碍)和未患精神病及无行为异常病人、服用精神类药品(如抗抑郁药、苯二氮?类药物、安眠药、镇定剂、抗精神病药品和用于治疗SUD、烟草戒断、多动症的药物)和未服用精神类药品病人之间接受阿片类药物治疗的区别。相对于对照组,有精神病或服用精神类药品的病人随后须接受阿片类药物治疗的风险稍高,特别是,接受阿片类药物长期治疗的风险更高。利用校正型Cox回归模型可知,多动症病人接受阿片类药物长期治疗的风险是无多动症病人的1.5倍(危险比(HR)=1.53,95%可信区间:1.48-1.58),非阿片类SUD病人风险约是无此疾患病人的3倍(危险比(HR)=3.15,95%可信区间:3.06-3.24),阿片类使用障碍病人的风险是无此疾患病人的9倍(危险比(HR)=8.70,95%可信区间:8.20-9.24)。总而言之,本研究发现有精神疾病状态的商业保险病人更可能接受阿片类药物治疗。未来关于阿片类药物行为结局的研究需考虑病人的先存精神疾病状况。 | Patrick D Quinn Kwan Hur Zheng Chang 王艳娉 杨俊龙 张小梅 | 2017 | 中国疼痛医学杂志2017，23，9： | 3 |
| 3 | Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province,Korea显示文摘 | Ok Y S Kim S C Kim K R Lee S S Moon D H Lim K J Sung J K Hur S O Yang J E | | 0，，： | 1 |
| 4 | 显示文摘 | Hur K H Jeong J H Lee D N | 1991 | Mater Sci1991，26，： | 1 |
| 5 | Haematologicalparameters and respiratory function in diploid andtriploid Far Eastern catfish, Silurus asotus显示文摘 | Seol D W Im S Y Hur W J | 2008 | genesgenomics2008，30，3： | 1 |
| 6 | A vaccine candidate for postweaning diarrhea in swine constructed with a live attenuated Salmonella delivering Escherichia coli K88ab, K88ac, FedA, and FedF fimbrial antigens and its immune responses in a murine model显示文摘 | Hur J Stein B D Lee J H | 2012 | Can J Vet Res2012，76，3： | 1 |
| 7 | Distributed implementation of generation scheduling algorithm on interconnected power systems显示文摘 | Chung K H Kim B H Hur D | 2011 | Energy Conversion and Management2011，52，12： | 1 |
| 8 | Evaluation of convergence rate in the auxiliary problem principle for distributed optimal power flow 显示文摘 | Hur D Park J K Kim B H | 2002 | IEE Proceedings-Gener Transm and Distrib2002，149，5： | 1 |
| 9 | Support vector clustering显示文摘 | Hur AB Horn D Siegelmann HT | 2001 | Machine Learning Research2001，，2： | 1 |
| 10 | Attribute-based Access Control with Efficient Revocation in Data Outsourcing Systems显示文摘 | Hur J Noh D K | 2011 | IEEE Transactions on Parallel and Distributed Systems2011，22，7： | 1 |
| 11 | Positioning empty containers among multiple ports with leasing and purchasing considerations显示文摘 | Moon 1 K Ngoc A D D Hur Y S | 2010 | OR Spectrum2010，32，3： | 1 |
| 12 | Isolation and characterization of pokeweed antiviral protein mutations in Saccharomyces cerevisiae : identification of residues important for toxicity显示文摘 | HUR Y HWANG D J ZOUBENKO O | 1995 | Proc Natl Acad Sci USA1995，92，18： | 1 |
| 13 | An alternative method for the reliability differentiated transmission pricing 显示文摘 | HUR D PARK J K LEE W G | 2004 | Electric Power Systems Research2004，，68： | 1 |
| 14 | A support vector method for hierarchical clustering显示文摘 | Hur AB Horn D Siegelmann HT | 2001 | Advances in Neural Information Processing Systems2001，，13： | 1 |
| 15 | The effect of stocking density in transit on the meat quality and blood profile of the slaughter pig显示文摘 | Lee J R Kim D H Hur T Y | 2000 | Journal of Ani- mal Science Technology (Korea)2000，42，： | 1 |
| 16 | Building automation system via LonWorks and Linux based personal computer显示文摘 | Hur S H Kim D W Park G T | 2006 | Automation in Construction2006，15，4： | 1 |
| 17 | Design for stiffness reinforcement in backward extrusion die显示文摘 | Hur K D Choi Y and Yeo H T | 2002 | Journal of Material Processing Technology2002，，130131： | 1 |
| 18 | Phase formation of Al2O3/Ti(C,N)-NiTi composite显示文摘 | XIU Z M LAENG J SUN X D LI Q HUR S K LIU Y N | 2008 | Journal of Alloys and Compounds2008，458，12： | 1 |
| 19 | Performance Analysis of Skewed PM linear Synchronous Motor According to Various Design Parameters 显示文摘 | L S Jung J Hur D S Hyun | 2001 | Magnetics IEEE Transactions on2001，37，5： | 1 |
| 20 | Evaluation of convergence rate in the auxiliary problem principle for distributed optimal power flow显示文摘 | HUR D PARK J K KIM B H | 2002 | IEE Proceedings-Generation Transmission and Distribution2002，149，5： | 1 |
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