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| 1 | Barrett's esophagus:Prevalence and risk factors in patients with chronic GERD in Upper Egypt显示文摘AIM:To determine the prevalence and possible risk factors of Barrett's esophagus(BE) in patients with chronic gastroesophageal reflux disease(GERD) in El Minya and Assuit, Upper Egypt.METHODS:One thousand consecutive patients with chronic GERD symptoms were included in the study over 2 years.They were subjected to history taking including a questionnaire for GERD symptoms, clinical examination and upper digestive tract endoscopy.Endoscopic signs suggestive of columnar-lined esophagus(CLE) were defined as mucosal tongues or an upward shift of the squamocolumnar junction.BE was diagnosed by pathological examination when specialized intestinal metaplasia was detected histologically in suspected CLE.pH was monitored in 40 patients.RESULTS:BE was present in 7.3% of patients with chronic GERD symptoms, with a mean age of 48.3 ± 8.2 years, which was signif icantly higher than patients with GERD without BE(37.4 ± 13.6 years).Adenocarcinomawas detected in eight cases(0.8%), six of them in BE patients.There was no signiflcant difference between patients with BE and GERD regarding sex, smoking, alcohol consumption or symptoms of GERD.Patients with BE had significantly longer esophageal acid exposure time in the supine position, measured by pH monitoring.CONCLUSION:The prevalence of BE in patients with GERD who were referred for endoscopy was 7.3%.BE seems to be associated with older age and more in patients with nocturnal gastroesophageal reflux. | Yasser M Fouad Madiha M Makhlouf Heba M Tawfik Hussein El Amin Wael Abdel Ghany Hisham R El-khayat | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 2 | Helicobacter pylori and gastric cancer in the Middle East: A new enigma?显示文摘The Middle East is the home of ethnic groups from three main backgrounds: Semitic (Arabs and Jews), Indo-European (Persians and Kurdish) and Turkic (Turkish and Turkmens). Its geographic location, which has been under continuous influences from Asia, Europe and Africa, has made it an ideal site for epidemiological studies on Helicobacter pylori (H. pylori) infection and genotyping. The gastric cancer rate differs in this region from very high in Iran (26.1/105) to low in Israel (12.5/105) and very low in Egypt (3.4/105). Epidemiological studies showed that the prevalence of H. pylori is almost similar in those countries with a high level of infection in childhood. Importantly, the frequency of vacA s1 and m1 regions and cagA+ genotypes were higher in non Semitic populations who inhabit the North than Semitic populations, the inhabitants of Southern parts of the Middle East. H. pylori infection prevalence, distribution pattern of virulence factors, diet and smoking could not have explained the difference in cancer rate. This reflects the multifactorial aetiology of gastric cancer and suggests that H. pylori infection does not always directly correlate with the risk for gastrointestinal disease, such as gastric cancer. Further detailed investigations and international comparative studies of each risk factor needto be performed to investigate whether this represents a true enigma. | Nawfal R Hussein | 2010 | World Journal of Gastroenterology2010，16，26： | 3 |
| 3 | Posterior lingual lidocaine: A novel method to improve tolerance in upper gastrointestinal endoscopy显示文摘AIM: To evaluate the effect of posterior lingual lidocaine swab on patient tolerance to esophagogastro-duodenoscopy, the ease of performance of the procedure, and to determine if such use will reduce the need for intravenous sedation. METHODS: Eighty patients undergoing diagnostic esophagogastroduodenoscopy in a tertiary care medical center were randomized to either lidocaine swab or spray. Intravenous meperidine and midazolam were given as needed during the procedure. RESULTS: Patients in the lidocaine swab group (SWG) tolerated the procedure better than those in the spray group (SPG) with a median tolerability score of 2 (1, 4) compared to 4 (2, 5) (P < 0.01). The endoscopists encountered less diffi culty performing the proceduresin the SWG with lower median difficulty scores of 1 (1, 5) compared to 4 (1, 5) in the SPG (P < 0.01). In addition, the need for intravenous sedation was also lower in the SWG compared to the SPG with fewer patients requiring intravenous sedation (13/40 patients vs 38/40 patients, respectively, P < 0.01). The patients in the SWG were more satisfi ed with the mode of local anesthesia they received as compared to the SPG. In addition, the endoscopists were happier with the use of lidocaine swab. CONCLUSION: The use of a posterior lingual lidocaine swab in esophagogastroduodenoscopy improves patient comfort and tolerance and endoscopist satisfaction and decreases the need for intravenous sedation. | Assaad M Soweid Shadi R Yaghi Faek R Jamali Abdallah A Kobeissy Michella E Mallat Rola Hussein Chakib M Ayoub | 2011 | World Journal of Gastroenterology2011，17，47： | 2 |
| 4 | Steep Dispersion and Group Velocity Below c/3000 in Coherent Population Trapping显示文摘 | SCHMIDT O WYNANDS R HUSSEIN Z | | 0，，： | 1 |
| 5 | Melatonin Reduces Oxidative Stress Induced by Ochratoxin A in Rat Liver and Kidney显示文摘 | Meki A R Hussein A A | 2003 | Comp Biochem Phsiol C Toxicol Pharmacol2003，130，3： | 1 |
| 6 | MCA flow cytometry is a marker for cerebrovascular disease显示文摘 | Steven U Hussein R Boris V | 1996 | Neurol Res1996，18，： | 1 |
| 7 | Phytoremediation of organo mercurial compounds via chloroplast genetic engineering 显示文摘 | Oscar N R Hussein S H Norman T | 2003 | Plant Physiology2003，132，2： | 1 |
| 8 | Assessment of heavy metal contamination in roadside surface soil and vegetation from the West Bank 显示文摘 | Swaileh K M Hussein R M Abu-Elhaj S | 2004 | Archives of Environmental Contamination and Toxicology2004，47，： | 1 |
| 9 | Phytoreme- diation of organomercurial compounds via chloroplast genetic engineering显示文摘 | Oscar N R Hussein S H Norman T | 2003 | Plant Physiology2003，132，13： | 1 |
| 10 | The effect of current mode and discharge type on the corrosion resistance of plasma electrolytic oxidation (PEO) coated magnesium alloy AJ62显示文摘 | Hussein R O Zhang P Nie X | 2011 | Surface and Coatings Technology2011，206，： | 1 |
| 11 | Structural characteristic of Na《,2》O-P《,2》O《,5》-GeO《,2》 glass systems显示文摘 | SAHAR M R WAHAB A HUSSEIN A | 2007 | J Non Cryst Solids2007，353，1112： | 1 |
| 12 | Oocyte-secreted factors enhance oocyte developmental competence显示文摘 | HUSSEIN T S THOMPSON J G GILCHRIST R B | 2006 | Develop Biol2006，296，2： | 1 |
| 13 | Supercritical of peppermint and spearmint 显示文摘 | Barton P Hunghes R E carbon dioxide extraction Hussein M M | 1992 | Journal of supercritical Fluids1992，5，3： | 1 |
| 14 | Glut-1 expres- sion correlates with basal-like breast cancer 显示文摘 | Hussein Y R Bandyopadhyay S Semaan A | 2011 | Transl Oncol2011，4，6： | 1 |
| 15 | Assessment of heavy metal contamination in roadside soil and vegetation from the west bank显示文摘 | Swaileh K M Hussein R M Abu-elhaj S | 2004 | Archives of Environmental Contamination and Toxicology2004，47，1： | 1 |
| 16 | Apoptosis and melanoma: molecular mechanisms显示文摘 | Hussein M R Haemel A K Wood G S | 2003 | Pathol2003，199，3： | 1 |
| 17 | A phase I multidose study of daeetuzumab ( SGN-40 ; humanized anti-CIM0 monoclonal antibody) in patients with multiple myeloma显示文摘 | Hussein M Berenson JR Niesvizky R | 2010 | Haematologica2010，95，5： | 1 |
| 18 | Spectroscopic study of electrolytic plasma and discharging behaviour during the plasma electrolytic oxidation (PEO) process显示文摘 | R O Hussein X Nie D O Northwood A Yerokhin A Matthews | 2010 | Journal of Physics D: Applied Physics2010，，10： | 1 |
| 19 | Characterization of Ti02-chitosaniglass photocatalyst for the removal of a monoazo dye via photodegradation-adsorption process显示文摘 | Zainal Z Hui L K Hussein M Z Abdullah A H Hamadneh I R | 2009 | Jour?nal of Hazardous Materials2009，164，1： | 1 |
| 20 | Assessment of heavy metal contamination in roadside surface soil and vegetation from the West Bank显示文摘 | Swaileh K M Hussein R M Abu-Elhaj S | 2004 | Archives of Environmental Contamination and Toxicology2004，47，1： | 1 |
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