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1篇 您的检索式：作者名="Hwangjae Lee"

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		题名	作者	年代	出处	被引量
	1	Remote induction of in situ hydrogelation in a deep tissue,using an alternating magnetic field and superparamagnetic nanoparticles显示文摘In situ hydrogelation systems, such as transdermal polymerization, allow forexternal control over the gelation processes in a minimally invasive way. Recently,a novel system consisting of near-infrared (NIR) light and plasmonic nano-materials was demonstrated to cause in vivo transdermal gelation. However,NIR light is not sufficient for gelation induction in deep tissues owing to itslimited penetration into tissues. To overcome this problem, here we developedan alternating magnetic field (AMF)-inducible hydrogelation system withsuperparamagnetic iron oxide nanoparticles (SPIONs), by which a deep-tissue-penetrating AMF can induce heat generation in the SPIONs and temperatureelevation (≥ 43℃), leading to initiation of thermal polymerization of poly(ethyleneglycol) diacrylate. The feasibility of our AMF-inducible hydrogelation wassuccessfully demonstrated using thick porcine muscle tissues (〉 2 cm), whereasthe NIR light-based hydrogelation system could induce gelation only in tissuesthinner than several millimeters. Cell viability assays indicated cytocompatibilityof the AMF-inducible hydrogelation for cell encapsulation and delivery. In vivohydrogelation in rat muscle tissues further validated in situ hydrogelation indeep muscle tissues of a living animal. This AMF-inducible hydrogelationsystem may overcome the conventional problems of depth limitation and shouldextend the applicable area of on-demand injectable hydrogel systems for tissueengineering and drug delivery applications.	Hwangjae Lee Guru Karthikeyan Thirunavukkarasu Semin Kim Jae Young Lee	2018	Nano Research2018，11，11：	1

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