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| 1 | Epoxy asphalt concrete paving on the deck of long-span steel bridges显示文摘It is the first systematic research in the world on the composition design of epoxy asphalt concrete as pav- ing material. Material characteristics and service perform- ance of mixture, fatigue resistance characteristics of epoxy asphalt concrete by the fatigue test of complex beam have also been described. This research indicates that epoxy as-phalt concrete is a good type of paving material. Research results have been applied successfully in the paving of steel deck of the Second Nanjing Yangtze River Bridge (SNYRB). It provides a new paving type for long-span steel bridges of China and has a bright application prospect. | HUANG Wei, QIAN Zhendong, CHEN Gang & YANG Jun Transportation College, Southeast University, Nanjing 210096, China Correspondence should be addressed to Huang Wei (e-mail: hwei@ seu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，21： | 47 |
| 2 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 3 | Palliative surgery for Krukenberg tumors—12-year experience and review of the literature显示文摘AIM To determine the clinical characteristics of patients undergoing palliative surgery for Krukenberg tumors,including disease presentation,outcomes,and prognostic factors.METHODS This was a retrospective clinical study of all patients who underwent palliative surgery for Krukenberg tumors between January 2004 and December 2015.Patient information was obtained from inpatient and outpatient case notes as well as the hospital electronic records.Patients who underwent potential y curative resection,and patients with Krukenberg tumors who did not undergo surgery were also excluded from the study.Palliative surgery was defined as those performed for either alleviation of symptoms or for asymptomatic patients for whom surgical removal of the tumors were deemed necessary following a multidisciplinary consensus.Tumors were diagnosed pre-operatively by computed tomography scans and all had histologic confirmation of the surgical specimens.RESULTS Over the study duration,38 female patients underwent palliative surgery for Krukenberg tumors at our institution.Mean age was 54.2±11.7 years.The colon was the most frequent primary source of metastases(n=21)followed by the stomach(n=4).Prophylactic palliative surgery was performed for eight(21.1%)asymptomatic patients.Median post-operative length of stay was 8 d(IQR 6-12 d).Five patients(13.2%)experienced postoperative complications,although high grade morbidity was only seen in one patient(2.6%).Median overall survival from surgery was 17 mo(95%CI:12.1-21.9)at a median follow-up duration of 12 mo(IQR 8-17mo).The median survival was shorter for patients who underwent emergency surgery,younger patients,those with a colorectal primary,larger tumors,or synchronous peritoneal or hepatic metastases.CONCLUSION Pal iative surgery for Krukenberg tumors can be performed safely with acceptable complication rates.Bilateral oophorectomy should be performed to prevent the risk of symptomatic contralateral tumors. | Isaac Seow-En Gwen Hwarng Grace Hwei Ching Tan Leonard Ming Li Ho Melissa Ching Ching Teo | 2018 | World Journal of Clinical Oncology2018，9，1： | 5 |
| 4 | Clinical and molecular characteristics of East Asian patients with von Hippel–Lindau syndrome显示文摘Background: Von Hippel–Lindau(VHL) syndrome is a dominantly inherited multisystem cancer syndrome caused by a heterozygous mutation in the VHL tumor suppressor gene. Previous studies suggested that similar populations of Caucasian and Japanese patients have similar genotype or phenotype characteristics. In this comprehensive study of East Asian patients, we investigated the genetic and clinical characteristics of patients with VHL syndrome.Methods: To create a registry of clinical characteristics and mutations reported in East Asian patients with VHL syndrome, we conducted a comprehensive review of English language and non?English language articles identi?fied through a literature search. Publications in Japanese or Chinese language were read by native speakers of the language, who then performed the data extraction.Results: Of 237 East Asian patients with VHL syndrome, 154 unique kindreds were identified for analysis. Analyzed by kindred, missense mutations were the most common(40.9%, 63/154), followed by large/complete deletions(32.5%, 50/154) and nonsense mutations(11.7%, 18/154). Compared with a previously reported study of both East Asian and non?East Asian patients, we found several key differences. First, missense and frameshift mutations in the VHL gene occurred less commonly in our population of East Asian patients(40.9% vs. 52.0%; P = 0.012 and 8.4% vs. 13.0%; P < 0.001, respectively). Second, large/complete deletions were more common in our population of East Asian patients(32.5% vs. 10.5%; P < 0.001). Third, phenotypically, we observed that, in our population of East Asian patients with VHL syndrome, the incidence of retinal capillary hemangioblastoma was lower, whereas the incidence of renal cell carcinoma was higher.Conclusions: Evidence suggests that the genotypic and phenotypic characteristics of East Asian patients with VHL syndrome differ from other populations. This should be considered when making screening recommendations for VHL syndrome in Asia. | Meihua Wong Ying-Hsia Chu Hwei Ling Tan Hideharu Bessho Joanne Ngeow Tiffany Tang Min-Han Tan | 2016 | Chinese Journal of Cancer2016，35，9： | 3 |
| 5 | Review of Cellulose Smart Material: Biomass Conversion Process and Progress on Cellulose-Based Electroactive Paper显示文摘Cellulose is a renewable biomass material and natural polymer which is abundantly available on Earth,and includes agricultural wastes,forestry residues,and woody materials.The excellent and smart characteristics of cellulose materials,such as lightweight,biocompatibility,biodegradability,high mechanical strength/stiffness and low thermal expansibility,have made cellulose a highpotential material for various industry applications.Cellulose has recently been discovered as a smart material in the electroactive polymers family which carries the name of cellulose-based electroactive paper(EAPap).The shear piezoelectricity in cellulose polymers is able to induce large displacement output,low actuation voltage,and low power consumption in the application of biomimetic sensors/actuators and electromechanical system.The present study provides an overview of biomass pretreatment from various lignocellulosic cellulose(LC)resources and nanocellulose production via TEMPO-mediated oxidation reaction,followed by the production of different types of EAPap versus its performance,and lastly the applications of EAPap in different areas and industries.Specifically,LC biomass consists mainly of cellulose having a small content of hemicelluloses and lignins which form a defensive inner structure against the degradation of plant cell wall.Thus,selective approaches are discussed to ensure proper extraction of cellulosic fibers from complex biomass for further minimization to nano-dimensions.In addition,a comprehensive review of the development of cellulose-based EAPap as well as fabrication,characterization,performance enhancement and applications of EAPap devices are discussed herein. | S.H.Hassan Lee Hwei Voon T.S.Velayutham Lindong Zhai Hyun Chan Kim Jaehwan Kim | 2018 | Journal of Renewable Materials2018，6，1： | 3 |
| 6 | Chemotherapy‐induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: A prospective study显示文摘 | Chiun Hsu Hsiao‐Hui Tsou Shyh‐Jer Lin Ming‐Chung Wang Ming Yao Wen‐Li Hwang Woei‐Yau Kao Chang‐Fang Chiu Sheng‐Fung Lin Johnson Lin Cheng‐Shyong Chang Hwei‐Fang Tien Tsang‐Wu Liu Pei‐Jer Chen Ann‐Lii Cheng | 2014 | Hepatology2014，，6： | 3 |
| 7 | MicroRNA-18a Prevents Estrogen Receptor-α Expression, Promoting Proliferation of Hepatocellular Carcinoma Cells显示文摘 | Wan–Hsin Liu Shiou–Hwei Yeh Cho–Chun Lu Sung–Liang Yu Hsuan–Yu Chen Chien–Yu Lin Ding–Shinn Chen Pei–Jer Chen | 2009 | Gastroenterology2009，，2： | 2 |
| 8 | Estrogen Receptor α Represses Transcription of HBV Genes via Interaction With Hepatocyte Nuclear Factor 4α显示文摘 | Sheng–Han Wang Shiou–Hwei Yeh Wei–Hsiang Lin Kun–Huei Yeh Quan Yuan Ning–Shao Xia Ding–Shinn Chen Pei–Jer Chen | 2012 | Gastroenterology2012，，4： | 2 |
| 9 | The effects of entrepreneurial orientation and marketing informa- tion on the performance of SMEs 显示文摘 | HEAN TATKEH THI TUYET MAI NGUYEN HWEI PING NG | 2007 | Journal of Business Venturing2007，22，： | 1 |
| 10 | Micromachined pre - focused M × N flow switch for continuous sample injection 显示文摘 | Lee G B Hwei B H Huang G R | 2001 | J Micromech Microeng2001，11，6： | 1 |
| 11 | Microbial agents for decolorization of dyewastewater显示文摘 | Duen Gang-mon Kim Kee-lim Hwei Ping-shen | 1991 | Biotechnol Adv1991，9，4： | 1 |
| 12 | A high serum interleukin‐12p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia显示文摘 | Jia‐Feng Wu Pei‐Chi Kao Huey‐Ling Chen Hong‐Shiee Lai Hong‐Yuan Hsu Mei‐Hwei Chang Yen‐Hsuan Ni | 2012 | Liver Int2012，，10： | 1 |
| 13 | Micromachined Pre-Focused M×N Flow Switches for Continuous Multi-Sample Injection显示文摘 | LEE GWO-BIN HWEI BAO-HERNG | 2001 | Journal of Micromechanics and Microengineering2001，11，6： | 1 |
| 14 | Biomechanical characteristics of pre- activation and pulling phases of snatch lift 显示文摘 | Yung Hui Lee Chin Yang Huwang and Yang Hwei Tsuang | 1995 | Journal of Applied Biomechanics1995，10，11： | 1 |
| 15 | The Adsorption of Fluoride Ion from A- queous Solution by Activated Alumina显示文摘 | Young K Hwei MC | 2002 | Water Air and Soil Pollution2002，133，14： | 1 |
| 16 | Composition and behaviors of probabilistic I/O automata显示文摘 | Hwey W S Smolka S A Stark E W | 1997 | Theoretical Computer Science1997，176，： | 1 |
| 17 | Interrelarionships a- mong stock prices of Taiwan and Japan and NTD/Yen exchange rate 显示文摘 | Hwey - Yun Yau Chien - Chung Nieh | 2006 | Journal of Asian Economics2006，，17： | 1 |
| 18 | Elevated p53 promotes the processing of miR‐18a to decrease estrogen receptor‐α in female hepatocellular carcinoma显示文摘 | Chiao‐Ling Li Kun‐Huei Yeh Wan‐Hsin Liu Chi‐Ling Chen Ding‐Shinn Chen Pei‐Jer Chen Shiou‐Hwei Yeh | 2015 | Cancer2015，，4： | 1 |
| 19 | The mechanism of gossypol detoxification by ru- minant animals 显示文摘 | Raymond R Hwei C F | 1962 | Journal of nutrition1962，76，： | 1 |
| 20 | Biomechanical Characteristics of Preactivation and Pulling Phases of Snatch Lift 显示文摘 | Yung - Hui Lee Chin - Yang Huwang and Yang - Hwei Tsuang | 1995 | Journal of applied biomechanics1995，，11： | 1 |
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