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12篇 您的检索式:作者名="Hyeonju"
    题名 作者 年代 出处 被引量
1Using pat- ent information for designing new product and technology: keyword based technology roadmapping 显示文摘Lee Sungjoo Lee Seonghoon Seol Hyeonju 2008R & D Manage- ment2008,28,2:1
2Using patent information for designing new product and technology:keyword based technology roadmapping显示文摘Sungjoo Lee Seonghoon Lee Hyeonju Seol 2008R&D Management2008,38,2:1
3IdentifyingCore Technologies Based on Technological Cross -impacts:AnAssociation Rule Mining (ARM) and Analytic Network Process(ANP) Approach 显示文摘Chulhyun Kim Hakyeon Lee Hyeonju Seol 2011Expert Systems with Applications2011,,12:1
4A stochastic patent citation analysis approach to assessing future technological impacts显示文摘Changyong Lee Yangrae Cho Hyeonju Seol Yongtae Park 2011Technological Forecasting & Social Change2011,,1:1
5Regenerative potential of mouse embryonic stem cell-derived PDGFRα+ cardiac lineage committed cells in infarcted myocardium显示文摘BACKGROUND Pluripotent stem cell-derived cardiomyocytes(CMs) have become one of the most attractive cellular resources for cell-based therapy to rescue damaged cardiac tissue.AIM We investigated the regenerative potential of mouse embryonic stem cell(ESC)-derived platelet-derived growth factor receptor-α(PDGFRα)+ cardiac lineagecommitted cells(CLCs), which have a proliferative capacity but are in a morphologically and functionally immature state compared with differentiated CMs.METHODSWe induced mouse ESCs into PDGFRα+ CLCs and αMHC+ CMs using a combination of the small molecule cyclosporin A, the rho-associated coiled-coil kinase inhibitor Y27632, the antioxidant Trolox, and the ALK5 inhibitor EW7197.We implanted PDGFRα+ CLCs and differentiated αMHC+ CMs into a myocardial infarction(MI) murine model and performed functional analysis using transthoracic echocardiography(TTE) and histologic analysis.RESULTS Compared with the untreated MI hearts, the anterior and septal regional wall motion and systolic functional parameters were notably and similarly improved in the MI hearts implanted with PDGFRα+ CLCs and αMHC+ CMs based on TTE.In histologic analysis, the untreated MI hearts contained a thinner ventricular wall than did the controls, while the ventricular walls of MI hearts implanted with PDGFRα+ CLCs and αMHC+ CMs were similarly thicker compared with that of the untreated MI hearts. Furthermore, implanted PDGFRα+ CLCs aligned and integrated with host CMs and were mostly differentiated into α-actinin+ CMs,and they did not convert into CD31+ endothelial cells or αSMA+ mural cells.CONCLUSION PDGFRα+ CLCs from mouse ESCs exhibiting proliferative capacity showed a regenerative effect in infarcted myocardium. Therefore, mouse ESC-derived PDGFRα+ CLCs may represent a potential cellular resource for cardiac regeneration.Seon Pyo Hong Sukhyun Song Seungjoo Lee Hyeonju Jo Hyoung Kyu Kim Jin Han Jae-Hyeong Park Sung Woo Cho 2019World Journal of Stem Cells2019,11,1:1
6Cyclospor in A elicits dosedependent biphasic effects on osteoblast differen- tiation and bone formation 显示文摘Hyeonju Y Lauren HB Jay MM 2007Bone2007,40,:1
7Cyclosporin A elicits dose-dependent biphasic effects on osteo- blast differentiation and bone formation 显示文摘Hyeonju Y Lauren HB Jay MM 2007Bone2007,40,:1
8A Patent Portfolio - based Ap-proach for Assessing Potential R显示文摘Bomi S Hyeonju S Yongtae P 2016Technological Forecasting & SocialChange2016,,103:1
9Cyelospor in A elieits dose de- pendent biphasie effects on osteoblast differentiation and bone formation 显示文摘Hyeonju Y Lanren HBo Jay MM 2007Bone2007,40,:1
10Using patent information for designing new product and technology:keyword based technology roadmapping显示文摘Sungjoo Lee Sconghoon Lee Hyeonju Seol 2008R&D Management2008,38,2:1
11Demand forecasting for new media services with consideration of competitive relationships u- sing the competitive Bass model and the theory of the niche 显示文摘HYEONJU SEOL GWANGMAN PARK HAKYEON LEE BYUNGUN YOON 2012Technological Forecasting and Social Change2012,79,7:1
12Us- ing patent information for designing new product and technolo- gy: keywo/d based technology roadmapping显示文摘Lee Sungjoo Lee Sconghoon SCol Hyeonju Park Yongtae 2008R&D Manage- ment2008,,3:1
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