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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 3 | Microstructure,Properties and Wear Behaviors of (Ni_3Al)_p Reinforced Cu Matrix Composites显示文摘Pure copper and its composites reinforced with Ni 3 Al particles were produced by powder metallurgy(PM).Ni 3 Al powders were produced by mechanical ball milling from vacuum arc melted compounds.The Ni 3 Al powders were characterized by X-ray diffraction(XRD).The microscopy examinations revealed that the Ni 3 Al particles were distributed uniformly in the matrix.The effects of the particle fraction on the density,electrical conductivity,strength and dry sliding wear resistance of composite were investigated.It was found that the density and electrical conductivity of the composites decrease while the compression yield strength and wear resistance of composites increase with an increase in the particle fraction.The dry sliding wear tests were performed with pin-on-disk geometry.After sliding wear tests,the worn surfaces were examined by scanning electron microscopy(SEM) equipped with an energy dispersive X-ray spectrometer(EDS).Results have shown that the wear mechanism is oxidative and adhesive. | Ibrahim elikyrek Nese .Krpe Tugba ler Remzi Grler | 2011 | Journal of Materials Science & Technology2011，27，10： | 2 |
| 4 | Diamond-like amorphous carbon thin films by dc magnetron sputtering显示文摘 | Saw K G Idrus RM Ibrahim K | 2000 | Journal of Materials Science Letters2000，19，9： | 1 |
| 5 | Traveling- wave -based fault- location scheme for multiend- aged underground cable system显示文摘 | GILANY M G IBRAHIM D K SAYED E | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 6 | mtDNA phylo geography and postglacial patterns of subdivision in the meadow grasshopper Chorthippus parallelus显示文摘 | Lunt D H Ibrahim K M Hewitt G M | 1998 | He redity1998，80，： | 1 |
| 7 | Experimental investigation of flame/solid interactions in turbulent premixed combustion显示文摘 | IBRAHIM S S HARGRAVE G K and WILLIAMS T C | 2001 | Experimental Thermal and Fluid Science2001，24，： | 1 |
| 8 | Studies of premixed flame propagation in explosion tubes显示文摘 | Fairweather M Hargrave G K Ibrahim S S | 1999 | Combustion and Flame1999，116，4： | 1 |
| 9 | Studies of premixed flame propagation in explosion tubes 显示文摘 | Fairweather M Hargrave G K Ibrahim S S | 1999 | Combustion and Flame1999，116，4： | 1 |
| 10 | Metal-organic framework materials with ultrahigh surface areas: is the sky the limit?显示文摘 | Farha Omar K Eryazici Ibrahim Jeong Nak Cheon Hauser Brad G Wilmer Christopher E Sarjeant Amy A Snurr Randall Q Nguyen SonBinh T Ozgox Yazaythn A Hupp Joseph T | 2012 | Journal of the American Chemical Society2012，134，15： | 1 |
| 11 | Studies of premixed flme propagation in explosion tubes显示文摘 | Fairweather M Hargrave G K Ibrahim S S | 1999 | Combustion and Flame1999，116，4： | 1 |
| 12 | Automatic produc- tion of quantisation matrices based on perceptual modeling of wavelet coefficients for grey scale images显示文摘 | Al-hudhud G Ibrahim M K A1-Akaidi M | 2010 | Image and Vision Computing2010，28，： | 1 |
| 13 | Bayesian Criterion Based Model Assessment for Categorical Data显示文摘 | Chen M H Dey D K Ibrahim J G | 2004 | Biometrika2004，91，： | 1 |
| 14 | Studies of premixed flame propagation in explosion tubes显示文摘 | Fairweather M Hargrave G K Ibrahim S S | 1996 | Combustion and Flame1996，，： | 1 |
| 15 | Association of flax seed yield and its components in Southeast Texas using path coefficient and biplot analyses显示文摘 | Darapuneni M K Morgan G D Ibrahim A M Duncan R W | 2014 | Journal of Crop Improvement2014，28，1： | 1 |
| 16 | Studies of premixed flame propagation in explosion tubes显示文摘 | Fairweather M Hargrave G K Ibrahim S S | 1999 | Combustion and Flame1999，116，4： | 1 |
| 17 | Differential immunoreactivity of epidermal growth factor receptor in benign,dysplastic and malignant prostatic tissues显示文摘 | IBRAHIM G K KERNS B J MACDONALD J A | 1993 | Journal of Urology1993，149，1： | 1 |
| 18 | Studies of premixed flame propagation in explosion tubes显示文摘 | Fairweather M Hargrave G K Ibrahim S S | 1999 | Combustion and Flame1999，11，6： | 1 |
| 19 | Studies of premixed flame propagation in explosion tubes 显示文摘 | Fairweather M Hargrave G K Ibrahim S S | 1999 | Combustion andFlame1999，116，： | 1 |
| 20 | Experimental investigation of flame/soild interactions in turbulent premixed combustion显示文摘 | Ibrahim S S Hargrave G K Williams T C | 2001 | Experimental Thermal and Fluid Science2001，24，： | 1 |
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