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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Beta-catenin regulates vascular endothelial growth factor expression in colon cancer显示文摘 | Easwaran V Lee S H Inge L | 2003 | Cancer Res2003，63，12： | 1 |
| 3 | Salt tectonics driven by dif- ferential sediment loading:stability analysis and finite-element experi- ments显示文摘 | Gemmer L Ings S J Medvedev S | 2004 | Basin Research2004，16，： | 1 |
| 4 | Detection and characterization of long pulse low velocity impact damage in plastic bonded explosives显示文摘 | Chen P W Huang F L Dai K D I)ing Y S | 2005 | International Journal of Impact Engineering2005，31，49： | 1 |
| 5 | Dynamic modelling of passive margin salt tectonics:effects of water loading, sediment properties andsedimentation patterns显示文摘 | Gemmer L Beaumont C Ings S J | 2005 | Basin Research2005，17，： | 1 |
| 6 | beta-Catenin regulates vascular endothelial growth factorexpression in colon cancer 显示文摘 | Easwaran V Lee S H Inge L Guo L Goldbeck C Garrett E etal | 2003 | Cancer Res2003，63，： | 1 |
| 7 | beta-Catenin regulates vascular endothelial growth factor expression in colon cancer显示文摘 | Easwaran V Lee S H Inge L | 2003 | Cancer Res2003，63，12： | 1 |
| 8 | Preimplantation genetic diagnosis 显示文摘 | Karen S Andre VS Inge L | 2004 | Lancet2004，363，9421： | 1 |
| 9 | Polar and brown bear genomes reveal ancient admixture and demographic footprints of past climate change显示文摘 | Miller W Schuster SC Welch AJ Ratan A Bedoya-Reina OC Zhao F Kim HL Burhans RC Drautz DI Wittekindt NE Tomsho LP Ibarra-Laclette E Herrera-Estrella L Peacock E Farley S Sage GK Rode K Obbard M Montiel R Bachmann L Ingólfsson(O) Aars J Mailund T Wiig Φ Tal | | 0，，： | 1 |
| 10 | Aromatic compounds produced by Periconia atropur purea ,an endophytic fungus associated with Xylopia aromatica显示文摘 | Teles H L Sordi R Silva G H Castro-Gamboa I Bolzani V S Pfen ing L H | 2006 | Phytochemistry2006，67，： | 1 |
| 11 | Use of surface response methodology to optimize culture conditions foriturin A production by Bacillus subtilis in solid-state fermentation显示文摘 | ING L S CHIA Y K FENG C H | 2008 | Journal of the Chinese Institute of Chemical Engineers2008，39，： | 1 |
| 12 | A framework for better understanding membrane distillation separation process显示文摘 | EI-BOURAWI M S l)ING Z MA R | 2006 | Journal of Membrane Science2006，285，12： | 1 |
| 13 | Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor 显示文摘 | Inge L J Barwe S P D'Ambrosio J | 2011 | Exp Cell Res2011，317，6： | 1 |
| 14 | The driving anger expression inventory: a measure of how people express their anger on the road显示文摘 | DEFFENBACHER J L LYNCH R S OE'I3?ING E R | 2002 | Behaviour Research & Therapy2002，40，6： | 1 |
| 15 | The influenence of salinity on the production of two commercially improtant unicellular marine algae 显示文摘 | LAING L UTI'ING S D | 1980 | Aquaculture1980，21，： | 1 |
| 16 | The influence of salinity on the production of two commercially important unicellular marine algae 显示文摘 | LAING L UTI'ING S D | 1980 | Aquaculture1980，21，： | 1 |
| 17 | Preimplantation genetic diagnosis 显示文摘 | Karen S Andre VS Inge L | 2004 | Lancet2004，363，9421： | 1 |
| 18 | A Change Detection Experiment Using Vegetation Indices 显示文摘 | JOHN G L D ING YUAN ROSS S L | 1998 | Photogrammetric En- gineering & Remote Sensing1998，64，2： | 1 |
| 19 | R ANK signaling is not required for TNFalpha-mediated increase in CD11(hi) o steoclast p recursors b ut is e ssential f or mature o steoclast formation in TNFalpha-mediated inflammatory arthritis显示文摘 | Li P S chwarz EM O'Keefe R J Ma L B oyce B F X ing L | | 0，，： | 1 |
| 20 | Evaluation of chemical coagulation flocculation aids for the removal of suspended solids and phosphorus from intensive recirculating aquaculture effluent discharge显示文摘 | EBEL ING J M SIBRELL P L OGDEN S R | 2003 | Aquacultural Engineering2003，29，： | 1 |
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