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| 1 | Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?显示文摘AIM:To determine whether acoustic radiation force impulse(ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus(HCV) hepatitis.METHODS:We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy(LB).In each patient we performed LB(evaluated according to the Metavir score) and ARFI measurements(using a Siemens Acuson S2000TM ultrasound system:10 valid measurements were performed and median values were calculated and expressed in meters/second(m/s).RESULTS:A direct,strong,correlation(Spearman r = 0.707) was found between ARFI measurements and fibrosis(P < 0.0001).For predicting the presence of fibrosis(F ≥ 1 Metavir),significant fibrosis(F ≥ 2),severe fibrosis(F ≥ 3) and cirrhosis(F = 4),the cutoff values of 1.19,1.21,1.58 and 1.82 m/s were determined,respectively,liver stiffness measurements had 73%,84%,84% and 91% Se respectively;93%,91%,94%,90% Sp,respectively;with AUROCs of 0.880,0.893,0.908 and 0.937,respectively.CONCLUSION:ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV | Ioan Sporea Roxana Sirli Simona Bota Carmen Fierbinteanu-Braticevici Alina Popescu Radu Badea Monica Lupsor Ana Petrisor Mirela Dnil | 2011 | World Journal of Radiology2011，3，7： | 24 |
| 2 | Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma显示文摘AIM: To analyze contrast-enhanced ultrasound(CEUS) features of histologically proven hepatic epithelioid hemangioendothelioma(HEHE) in comparison to other multilocular benign focal liver lesions(FLL).METHODS: Twenty-five patients with histologically proven HEHE and 45 patients with histologically proven multilocular benign FLL were retrospectively reviewed. Four radiologists assessed the CEUS enhancement pattern in consensus.RESULTS: HEHE manifested as a single(n = 3) or multinodular(n = 22) FLL. On CEUS, HEHE showed rim-like(18/25, 72%) or heterogeneous hyperenhancement(7/25, 28%) in the arterial phase and hypoenhancement(25/25, 100%) in the portal venous and late phases(PVLP), a sign of malignancy. Eighteen patients showed central unenhanced areas(18/25, 72%); in seven patients(7/25, 28%), more lesions were detected in the PVLP. In contrast, all patients with hemangioma and focal nodular hyperplasia showed hyperenhancement as the most distinctive feature(P < 0.01).CONCLUSION: CEUS allows for characterization of unequivocal FLL. By analyzing the hypoenhancement in the PVLP, CEUS can determine the malignant nature of HEHE. | Yi Dong Wen-Ping Wang Vito Cantisani Mirko D'Onofrio Andre Ignee Lorenzo Mulazzani Adrian Saftoiu Zeno Sparchez Ioan Sporea Christoph F Dietrich | 2016 | World Journal of Gastroenterology2016，22，19： | 21 |
| 3 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 4 | Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: A systematic review显示文摘AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Adriana Maria Neghinǎ Mirela Dǎnilǎ Mihnea Strǎin | 2013 | World Journal of Hepatology2013，5，3： | 6 |
| 5 | Pegylated-interferon alpha 2a treatment for chronic hepatitis C in patients on chronic haemodialysis显示文摘瞄准:评估反应到 pegylated 干扰素高山哈在长期的血液透析上的长期的丙肝病人的 2a。方法:有长期的 C 肝炎的十个病人在这研究被注册。所有为超过 6 瞬间,积极 antiHCV 抗体和积极 PCR HCV-RNA 增加了 aminotransferases。我们管理了木钉干扰素高山哈 2a 为 48 wk 的 180 microg/wk。在治疗的 12 wk 以后,我们评估了生物化学、早的 virological 反应(EVR ) 。在治疗的结束,我们在我们评估了的治疗的结束以后评估了生物化学的反应和 24 wk 持续 virological 反应(SVR ) 。我们在治疗期间监视了副作用。结果:二个病人在治疗的开始的 12 wk 放弃了并且 2 在治疗的开始的 12 wk 以后。在治疗的 12 wk 以后, 7 从 8 个病人有生物化学的反应和 EVR, 1 有生物化学的反应但是坚持的病毒血。我们不得不在 2 种情况中把 pegylated 干扰素的剂量归结为 135 mug/wk。三(50%) 从 6,病人们在治疗的结束以后有 SVR 24 wk。Intention-to-treat 分析证明 3 从 10 个病人(30%) 有 SVR。副作用发生在大多数病人(像流感的症候群,血小板减少或 leucopoenia ) ,但是他们没强加治疗的中止。结论:在有木钉干扰素高山的治疗的 12 wk 以后哈在有长期的 C 肝炎的长期的血液透析上的病人的 2a (40 ku ) , EVR 在 87.5% 被获得(7/8 ) 盒子。SVR 在完成了治疗的 48 wk 的 50% 盒子(3/6 病人) 中被完成。 | Ioan Sporea Alina Popescu Roxana ■irli Ovidiu Golea CameliaTotolici Mirela Dǎnilǎ Corina Vernic | 2006 | World Journal of Gastroenterology2006，12，26： | 2 |
| 6 | Value of acoustic radiation force impulse elastography for the assessment of ascites syndrome显示文摘AIM:To assess the feasibility of performing acoustic radiation force impulse(ARFI) elastography in patients with ascites and its predictive value for the cirrhotic or non-cirrhotic etiology of ascites.METHODS:Our study included 153 patients with ascites,mean age 58.8 ± 13.1 years.One hundred and fifteen(75.2%) patients had ascites in the context of cirrhosis,29(18.9%) had non-cirrhotic ascites(diagnosed by clinical,ultrasound,endoscopic and/or laparoscopic criteria) and in 9(5.9%) cases we could not establish the etiology of ascites.We performed 10 ARFI measurements and the median value was calculated and expressed in meters/second(m/s).Among the 29 patients with non-cirrhotic ascites were included:20 laparoscopically demonstrated peritoneal carcinomatosis with histological confirmation,7 acute pancreatitis with ascites which later resolved,and one case each of lymphatic ascites and ascites in the context of a liver abscess.In 11 of the 20 patients with peritoneal carcinomatosis,the liver structure was homogenous in the ultrasound examination and in 9 patients the ultrasound exam revealed liver metastases.RESULTS:We could not obtain valid ARFI measurements in 5 patients(3.2%).The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites:3.04 ± 0.70 vs 1.45 ± 0.59 m/s(P < 0.001).For a cut-off value of 1.8 m/s for predicting cirrhosis(and ascites in the context of cirrhosis),as obtained in a previous study,ARFI had 98.1% sensitivity,86.2% specificity,96.4% positive predictive value,92.5% negative predictive value and 95.6% accuracy for predicting cirrhotic ascites.For a cut-off value of 1.9 m/s the accuracy was 94.9% and for a 2 m/s cut-off value it was 92.8%.CONCLUSION:ARFI elastography is feasible in most patients with ascites and has a very good predictive value for the cirrhotic or non-cirrhotic etiology of ascites. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Mirela Dǎnilǎ Mǎdǎlina Sendroiu | 2011 | World Journal of Radiology2011，3，8： | 2 |
| 7 | Use of Intelligent-Particle Swarm Optimization in Electromagnetics显示文摘 | Ciuprina G Ioan D Munteanu I | 2002 | IEEE Trans on Magnetics2002，38，2： | 1 |
| 8 | Differential scanning calorimetry study of asphalt crystallite显示文摘 | William D H Qiu Zhaoyao Ioan N | | 0，，： | 1 |
| 9 | Use of intelligent-particle swarm optimization in electromagnetism显示文摘 | Ciuprina G Ioan D Munteanu I | 2002 | IEEE Trans on Magnetics2002，38，2： | 1 |
| 10 | Virtual instrume- ntation application for vibration analysis in electrical equipments testing 显示文摘 | IOAN L VISAN D A CIOC I B | 2010 | IEEE Conference Publica-tions2010，，： | 1 |
| 11 | Use of Intelligent-Particle Swarm Optimization in Electrornagnetics显示文摘 | Ciuprina G Ioan D Munteanu I | 2002 | IEEE Trans on Magnetics2002，38，2： | 1 |
| 12 | Use of intelligent-particle swarm optimization in electromagnetics 显示文摘 | Ciuprina G Ioan D Munteanu I | 2002 | IEEE Trans on Magnetics2002，38，2： | 1 |
| 13 | Use of Intelligent Particle Swarm Optimization in Electromagnetics显示文摘 | Ciupxina G Ioan D Munteanu I | | 0，，02： | 1 |
| 14 | Transcranial Doppler microembolic signals and serum marker evidence of brain injury during transcatheter aortic valve implantation显示文摘 | Reinsfelt B Westedind A Ioanes D | | 0，，02： | 1 |
| 15 | Use of Intelligent-Particle Swarm Optimization in Electromagnetics显示文摘 | Ciuprina G Ioan D Munteanu I | 2002 | Ieee Trans on Magnetics2002，38，2： | 1 |
| 16 | Transcranial Doppler microembolic signals and serum marker evidence of brain injury during transcatheter aortic valve implantation显示文摘 | Reinsfelt B Westerlind A Ioanes D | | 0，，02： | 1 |
| 17 | Transcranial doppler miroembolic signals and serum marker evidence of brain injury during transcatheter显示文摘 | Reinsfelt B Westerlind A Ioanes D | | 0，，： | 1 |
| 18 | Use of intelligent-particle swarm optimization in electromagnetics显示文摘 | CIUPRINA G IOAN D MUNTEANU I | 2002 | IEEE Trans Magn2002，38，2： | 1 |
| 19 | Use of intelligent-partide swarm optimization in electromagnetics显示文摘 | Ciuprina G Ioan D Munteanu I | 2002 | IEEE Trans on Magnetics2002，38，2： | 1 |
| 20 | Percutaneous ethanol injection therapy in the treatment of hepatocarcinoma results obtained from a series of 88 cases显示文摘 | Mirela D Ioan S Roxana S | 2009 | J Gastrointestinal Liver2009，18，3： | 1 |
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