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| 1 | Management of pancreaticobiliary disease using a new intra-ductal endoscope:The Texas experience显示文摘AIM:To evaluate a new single-operator mini-endoscope, Spyglass,for its performance,feasibility and safety in the management of pancreaticobiliary disease. METHODS:In a multicenter retrospective analysis of patients undergoing intraductal endoscopy,we evaluated 128 patients(71 men,mean age 57.6 years).Indications were therapeutic(TX)in 72(56%) and diagnostic(DX)in 56(44%). RESULTS:Peroral endoscopy was performed in 121 and percutaneous in seven.TX indications included CBD stones in 41,PD stones in six,and biliary strictures in 25.DX indications included abnormal LFT’s in 15, abnormal imaging in 38 and cholangiocarcinoma staging in three.Visualization of the stone(s)was considered good in 31,fair in six,and poor in four. Advancement of the electrohydraulic lithotripsy probe was not possible in three patients and proper targeting of the lesion was partial in four patients.A holmium laser was used successfully in three patients.Ductal clearance was achieved in 37 patients after one procedure and in four patients after two procedures.Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.Of the modified patients,no diagnosis was available in 17.Spyglass demonstrated malignancy in 8/17 and non-malignancy in nine.Suspected pathology by imaging studies and abnormal LFT’s was modified in 43/63(66%).Staging of cholangiocarcinoma demonstrated multicentric cholangiocarcinoma in 2/3.There was no morbidity associated with the use of Spyglass. CONCLUSION:Spyglass Spyscopeis a first generation, single operator miniature endoscope that can evaluate and treat various biliary and pancreatic tract diseases. | Douglas S Fishman Paul R Tarnasky Sandeep N Patel Isaac Raijman | 2009 | World Journal of Gastroenterology2009，15，11： | 22 |
| 2 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 3 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 4 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 5 | Diagnostic and therapeutic role of endoscopic retrograde cholangiopancreatography in biliary rhabdomyosarcoma显示文摘Biliary rhabdomyosarcoma (BRMS) is an uncommon childhood malignancy which has been managed surgically. We present a case of a 3-year-old boy with BRMS, in whom endoscopic retrograde cholangiopancreatography (ERCP) was successfully used both diagnostically and therapeutically, thus obviating the need for surgery and its attendant risks of morbidity and mortality. We conclude that ERCP is an effective alternative to surgery for BRMS in some patients. | Ryan W Himes Isaac Raijman Milton J Finegold Heidi V Russell Douglas S Fishman | 2008 | World Journal of Gastroenterology2008，14，30： | 2 |
| 6 | IL-1 beta-mediated up-regulation of HIF-1alpha via an NF-kappaB/COX-2 pathway identifiesHIF-1 as a critical link between inflammation and oncogenesis显示文摘 | Jung YJ Isaacs JS Lee S | 2003 | FASEB J2003，17，14： | 1 |
| 7 | Class Ⅲ beta-tubulin expression in tumor cells predicts response and outcome in patients with nonsmall cell lung cancer receiving paclitaxel显示文摘 | Seve P Mackey J Isaac S | 2005 | Mol Cancer Ther2005，4，12： | 1 |
| 8 | Effect of nitrite on anoxic phosphate uptake in biological phosphorus removal activated sludge 显示文摘 | Meinhold J Arnold E Isaacs S | 1998 | Wat Res1998，33，8： | 1 |
| 9 | Improving doctor - patient communication in the outpatient setting using a facil- itation tool: a preliminary study 显示文摘 | Neeman N Isaac T Leveille S | 2012 | Int J Quality Health Care2012，24，4： | 1 |
| 10 | Development of prostate cancer treatment : the good news显示文摘 | Denmeade S R Isaacs J T | 2004 | Prostate2004，58，： | 1 |
| 11 | Expression of class Ⅲ { beta }-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy显示文摘 | Seve P Isaac S Tredan O | 2005 | Clin Cancer Res2005，11，15： | 1 |
| 12 | Effect of continuous addition of an organic substrate to the anoxic phase on biological phosphorus removal显示文摘 | Meinhold J Arnold E Isaacs S | 1998 | Wat SciTech1998，38，1： | 1 |
| 13 | Improving purchasing productivity at IBM with a normative decision support system显示文摘 | Bender P S Brown R W Isaac H | 1985 | Interfaces1985，15，： | 1 |
| 14 | Expression of class Ⅲ {beta}-tu- bulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy 显示文摘 | Seve P Isaac S Tredan O | 2005 | Clin Cancer Res2005，11，15： | 1 |
| 15 | Assessment and validation of a microinjection method for kinetic analysis of Ca2+i in individual cells undergoing apoptosis显示文摘 | TOMBAL B DENMEADE S R ISAACS J T | 1999 | Cell Calcium1999，25，： | 1 |
| 16 | Evaluation of the coronary sinus on chest computed tomography in patients with and without pulmonary artery hypertension 显示文摘 | Isaacs D Hazany S Gamst A | 2009 | J Comput Assist Tomogr2009，33，4： | 1 |
| 17 | Crystal structure of an integral membrane light-harvesting complex from photosynthtic bacteria显示文摘 | McDermott G Prince S M Freer A A Hawthorthwaite-Lawless A M Papiz M Z Cogdell R J Isaacs N W | 1995 | Nature1995，374，6： | 1 |
| 18 | Effect of pressure on processes modelling the Maillard reaction显示文摘 | Isaacs N S Coulson M | 1996 | Journal of Physical Organic Chemistry1996，，9： | 1 |
| 19 | Expression of class Ⅲ beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy显示文摘 | Dumontet C Isaac S Souquet PJ | 2005 | Bull Cancer2005，92，1： | 1 |
| 20 | Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy 显示文摘 | Dumontet C Isaac S Souquet P J | 2005 | Bull Cancer2005，92，2： | 1 |
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