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您的检索式：作者名="Ian D.Small"
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| 1 | The Expansion and Diversification of Pentatricopeptide Repeat RNA-Editing Factors in Plants显示文摘The RNA-binding pentatricopeptide repeat(PPR)family comprises hundreds to thousands of genes in most plants,but only a few dozen in algae,indicating massive gene expansions during land plant evolution.The nature and timing of these expansions has not been well defined due to the sparse sequence data available from early-diverging land plant lineages.In this study,we exploit the comprehensive OneKP datasets of over 1000 transcriptomes from diverse plants and algae toward establishing a clear picture of the evolution of this massive gene family,focusing on the proteins typically associated with RNA editing,which show the most spectacular variation in numbers and domain composition across the plant kingdom.We characterize over 2250000 PPR motifs in over 400000 proteins.In lycophytes,polypod ferns,and hornworts,nearly 10%of expressed protein-coding genes encode putative PPR editing factors,whereas they are absent from algae and complex-thalloid liverworts.We show that rather than a single expansion,most land plant lineages with high numbers of editing factors have continued to generate novel sequence diversity.We identify sequence variations that imply functional differences between PPR proteins in seed plants versus non-seed plants and variations we propose to be linked to seed-plant-specific editing co-factors.Finally,using the sequence variations across the datasets,we develop a structural model of the catalytic DYW domain associated with C-to-U editing and identify a clade of unique DYW variants that are strong candidates as U-to-C RNA-editing factors,given their phylogenetic distribution and sequence characteristics. | Bernard Gutmann Santana Royan Mareike Schallenberg-Rudinger Henning Lenz Ian R.Castleden Rose McDowell Michael AVacher Julian Tonti-Filippini Charles SBond Volker Knoop Ian D.Small | 2020 | Molecular Plant2020，13，2： | 0 |
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