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	题名	作者	年代	出处	被引量
1	Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome.	Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel	2006	World Journal of Gastroenterology2006，12，39：	3
2	Serious infections in patients with inflammatory bowel disease receiving anti‐tumor‐necrosis‐factor‐alpha therapy: An Australian and New Zealand experience显示文摘	Ian CLawrance Graham LRadford‐Smith Peter ABampton Jane MAndrews Pok‐KernTan AnthonyCroft Richard BGearry Timothy H JFlorin	2010	Journal of Gastroenterology and Hepatology2010，，11：	2
3	导致成人多囊肾血尿的原因显示文摘	Robert Dedi Sunil Bhandari John H Turney Aleck M Brownjohn Ian EardLey 李寒	2002	英国医学杂志中文版2002，5，3：	2
4	Arithmetic Coding for Data Compression 显示文摘	Neal Radford M Cleary John G	1987	Communications of the ACM1987，30，6：	1
5	Arithmetic coding for data compression 显示文摘	Witten Ian H Neal Radford M Cleary John G	1987	Communications of the Association for Computing Machinery1987，30，6：	1
6	Wireless Sensor and Actor Networks : Research Challenges显示文摘	Akyildiz Ian F Kasimoglu Ismail H	2004	Ad Hoe Net- works2004，2，4：	1
7	Complete genome sequence of the shrimp white spot bacilliform virus 显示文摘	Yang F He J IAn X H	2001	J Virol2001，75，11：	1
8	HPV6b L1 virus like particles are potent immunogens without adjuvant in man 显示文摘	Lifang Zhang Jian Zhou Ian H Frazer	2000	Vaccine2000，18，1112：	1
9	Explaining national climate change policies显示文摘	IAN H ROWLANDS	1995	Global Environmental Change1995，3，3：	1
10	Production of submieron diameter silk fibers under benign processing conditions by two-fluid electrospinning显示文摘	Wang Mao Yu J ian H Kaplan D L	2006	Macromolecules2006，39，3：	1
11	Functional motor neurons differentiating from mouse multipotent spinal cord precursor cells in culture and after transplantation into transected sciatic nerve 显示文摘	Stephen C Ian G Shawn H	2003	J Neurosurg2003，98，：	1
12	The design and construction of a 250bar hyperbaric welding research facility显示文摘	John H Nixon Ian M Richardson	1995	Materials Engineering1995，3，2：	1
13	Arithmetic coding for data compression显示文摘	Ian H W Radford N W JohnCG	1987	Communication of the ACM1987，30，6：	1
14	GPS muhipath mitiga-tion:a nonlinear regression approach 显示文摘	Phan Q H Tan S L Ian McLoughlin	2013	GPS Solut2013，17，：	1
15	Isoform-specific alanine aminotransferase measurement can distinguishhepatic from extrahepatic injury in humans显示文摘	Ingalill Rafter Truls Gr?berg Anna Kotronen Lovisa Str?mmer C. Mattson Ray Kim Ewa Ehrenborg H?kan Andersson Hannele Yki-J?rvinen Ina Schuppe-Koistinen Bj?rn Ekblom Ian Cotgreave Bj?rn Glinghammar	2012	International Journal of Molecular Medicine2012，，5：	1
16	Distribution and abundance of Antarctic krill (Euphausia superba) off East Antarctica (80-150E) during the Austral summer of 1995/1996显示文摘	Tim P Stephen N Ian H	2000	Deep-Sea Res I/2000，47，：	1
17	Otolith sulfur isotope method to reconst ruct salmon(on-corhynchus Tshawytscha)life history显示文摘	Weber P K Ian D H Kevin D M	2002	Canadian Journal of Fisheries and Aquatic Sciences2002，59，：	1
18	The incidence of denervation of the saerospinales muscles following spinal surgery 显示文摘	Macnab IAN Cuthbert H Godfrey CM	1977	Spine1977，2，4：	1
19	Viral encephalitis:a clinician’s guide显示文摘	Tom S Ian J H Nicholas J B	2007	Practical Neurology2007，7，：	1
20	Recommender systems 显示文摘	Resn Ick P Var Ian H R	1997	Communications of ACM1997，40，3：	1

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