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| 1 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 4 | Noninvasive ventilator triggering in chronic obstructive pulmonary disease显示文摘 | Ian M Stell Graham P | 2001 | Am J Respir Crit Care Med2001，164，： | 1 |
| 5 | Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled β2-agonists in achieving asthma control显示文摘 | Paul M O'Byrne Ian P | 2008 | Chest2008，134，： | 1 |
| 6 | Terrain analysis:integration into the agricultural nonpoint source (AGNPS) pollution model显示文摘 | John C P Ian D M Larry A K | 1991 | J Soil and Water Conservation1991，，1： | 1 |
| 7 | RF-based partial discharge early warning system for air insulated substations显示文摘 | Iliana E P Philip J M Ian A G | 2009 | IEEE Transactons on Power Delivery2009，24，1： | 1 |
| 8 | Psychological and in- terpersonal dimensions of sexual function and dysfunction显示文摘 | McCahe M Althof S E Assa|ian P | 2010 | J Sex Med2010，7，12： | 1 |
| 9 | RF-based partial dis- charge early waring system for air-insulated substations显示文摘 | Iliana E P Philip J M Ian A G | 2009 | IEEE Trans on Power Delivery2009，24，1： | 1 |
| 10 | Otolith sulfur isotope method to reconst ruct salmon(on-corhynchus Tshawytscha)life history显示文摘 | Weber P K Ian D H Kevin D M | 2002 | Canadian Journal of Fisheries and Aquatic Sciences2002，59，： | 1 |
| 11 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
| 12 | Characterization of gas shalepore systems by porosimetry,pycnometry,surface area,and fieldemission scanning electron microscopy/transmission electron mi-croscopy image analyses:Examples from the Barnett,Woodford,Haynesville,Marcellus,and Doig units显示文摘 | Chalmers G R Bustin R M Ian P M | 2012 | AAPG Bulletin2012，96，6： | 1 |
| 13 | Mechanisms of gentamicin resistance in Gram-negative bacilli in Riyadh, Kingdom of Saudi Arabia 显示文摘 | Ahmed M Kevin S Ian P | 1989 | J Antimicrob Chemother1989，24，： | 1 |
| 14 | Global Changes in Marine Systems: a Social-Ecological Approach 显示文摘 | Ian R P Barange M Ommer R E | 2010 | Progress in Oceanography2010，，9： | 1 |
| 15 | Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial显示文摘 | Hagop M Kantarjian Andreas Hochhaus Giuseppe Saglio Carmino De Souza Ian W Flinn Leif Stenke Yeow-Tee Goh Gianantonio Rosti Hirohisa Nakamae Neil J Gallagher Albert Hoenekopp Rick E Blakesley Richard A Larson Timothy P Hughes | 2011 | Lancet Oncology2011，，9： | 1 |
| 16 | Quantitative Assessment of Assisted Prob-lem-based Learning in a Pharmaceutics Course显示文摘 | Rebecca M Stuart P Ian S | 2010 | American Journalof Pharmaceutical Education2010，74，4： | 1 |
| 17 | Detection of Bordet Ella pertussis and respiratory synclinal virus in air samples from hospital rooms显示文摘 | Aintab Ian N Walpita P Sawyer M H | 1998 | Infect Control HospEpidermal1998，19，12： | 1 |
| 18 | Part II polypeptides involved in foam forotation显示文摘 | Kenneth A L Graham G S Ian P M Beer polypeptides and silica gel | 2003 | Inst Brew2003，109，1： | 1 |
| 19 | Light-triggered theranostics based on photosensitizePconjugated carbon dots for sinm显示文摘 | Huang P IAn J Wang X S Wang Z Zhang C L He M Wang K Chen F Li Z M Shen G X | 2012 | Advanced Materials2012，24，37： | 1 |
| 20 | Early detection of anthracycline-mediated cardiotoxicity , the value of considering both global left ventricular strain and twist显示文摘 | Crist ian M Lucian P | 2013 | CanJ Physiol Pharmacol2013，91，： | 1 |
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