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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | Wireless multimedia sensor network: a survey显示文摘 | Ian F A Tommaso M Kaushik R C | 2007 | IEEE Wireless Communications2007，14，6： | 1 |
| 4 | Induction of heat shock proteins in differentiated human and rodent neurons by celastrol 显示文摘 | ARI M C IAN R B | 2007 | Cell Stress Chaperon2007，12，3： | 1 |
| 5 | Application of the Structured Illumination Method for Automated Visual Inspection of the Loudspeaker Cones显示文摘 | IAao C W Su J C IAn Y R | 2008 | Journal of Materials Processing Technology2008，20，10： | 1 |
| 6 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
| 7 | 14-3-3 proteins: structure, function, and regulation 显示文摘 | FU H SUBRAMan IAN R R MASTERS S C | 2000 | Annu Rev Pharmacol Toxicol2000，40，： | 1 |
| 8 | The influence of particle size distribution on the processing of food 显示文摘 | SERVAIS C RICHARD J IAN R | 2002 | J Food Eng2002，51，3： | 1 |
| 9 | Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losarran显示文摘 | Haisong J Nicole L R | 1997 | J Mol Cell Cardiol1997，29，： | 1 |
| 10 | Mitochondrial ribosomal RNA mutation associated with both antibiotic2induced and non syndromic deafness 显示文摘 | PREZANT T R AGAP IAN J V BOHLMAN M C | 1993 | Nat Genet1993，4，： | 1 |
| 11 | Combination of ceftriaxone And acyclovir an underestimated nephrotoxic potentia显示文摘 | Blair C Ian R | 2002 | Pedi-atric Nephrology2002，17，8： | 1 |
| 12 | Sensing andadaptingtoacidstress显示文摘 | Ian R Booth P Cash C O Byrne | 2002 | AntonievanLeeuwenhoek2002，81，： | 1 |
| 13 | Optimal guaranteed cost control and filtering for uncertain linear systems显示文摘 | Petersen Ian R Mcfariane D C | 1994 | IEEE Transaction on Automatic Control1994，39，9： | 1 |
| 14 | 流行病学和临床研究中数据缺失的多重填补:机会和陷阱显示文摘许多研究都存在缺失数据。Jonathan | Jonathan A C Sterne Ian R White John B Carlin Michael Spratt Patrick Royston Michael G Kenward Angela M Wood James R Carpenter 张清(译) 张孔来(校) | 2009 | 英国医学杂志中文版2009，12，6： | 1 |
| 15 | A novel app roach to spot detection for two-dimensional gel electrophoresis images using pixel value collection显示文摘 | PAUL C GEOFFERY H IAN R | 2003 | Proteomics2003，3，： | 1 |
| 16 | The impact of reliance on incentive-based compensation schemes, information asymmetry and organizational commitment on managerial performance显示文摘 | Chong Vincent K and Ian R C Eggleton | 2007 | Management Accounting Research2007，18，： | 1 |
| 17 | Constraints on spatial variability in soft-sediment Communities affected by contamination from an Antarctic waste disposal site显示文摘 | Jonathan S S Ian S Martin J R Scott C S | 2005 | Marine Pollution Bulletin2005，50，3： | 1 |
| 18 | The Impact ofMarket Competition and Budgetary Participation onPerformance and Job Satisfaction: A Research Note显示文摘 | Vincent K E Ian R C Michele K C | 2005 | British Accounting Review2005，23，3： | 1 |
| 19 | Industrial clusters,transactions costs and the institutional determinants of MNE location behaviour显示文摘 | PHILIP M C TOMOKAZU A IAN R G | 2002 | International Business Review2002，4，11： | 1 |
| 20 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial显示文摘 | George D Demetri Allan T van Oosterom Christopher R Garrett Martin E Blackstein Manisha H Shah Jaap Verweij Grant McArthur Ian R Judson Michael C Heinrich Jeffrey A Morgan Jayesh Desai Christopher D Fletcher Suzanne George Carlo L Bello Xin Huang Charles | 2006 | The Lancet2006，，9544： | 1 |
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