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| 1 | Main controversies in breast cancer显示文摘In this article, we have reviewed available evidence for diagnosis, treatment, and follow-up in female breast cancer(BC). Into daily clinical practice some controversies are occurred. Especially, in the diagnosis field, despite the fact that the optimal age in which screening mammography should start is a subject of intense controversy, there is a shift toward the beginning at the age of 40 although it is suggested that the net benefit is small for women aged 40 to 49 years. In addition, a promising tool in BC screening seems to be breast tomosynthesis. Other tools such as 3D ultrasound and shear wave elastography(SWE) are full of optimism in BC screening although ultrasonography is not yet a first-line screening method and there is insufficient evidence to recommend the systemic use of the SWE for BC screening. As for breast magnetic resonance imaging(MRI), even if it is useful in BC detection in women who have a strong family history of BC, it is not generally recommended as a screening tool. Moreover, based on the lack of randomized clinical trials showing a benefit of presurgical breast MRI in overall survival, it's integration into breast surgical operations remainsdebatable. Interestingly, in contrast to fine needle aspiration, core biopsy has gained popularity in presurgical diagnosis. Furthermore, after conservative surgery in patients with positive sentinel lymph nodes, the recent tendency is the shift from axillary dissection to axillary conserving strategies. While the accuracy of sentinel lymph node after neoadjuvant chemotherapy and second BC surgery remains controversial, more time is needed for evaluation and for determining the optimal interval between the two surgeries. Additionally, in the decision between immediate or delayed breast reconstruction, there is a tendency in the immediate use. In the prevention of BC, the controversial issue between tamoxifen and raloxifene becomes clear with raloxifene be more profitable through the toxicities of tamoxifen. However, the prevention of bone metastasis with bisphosphonates is still conflicting. Last but not least, in the follow-up of BC survivors, mammography, history and physical examination are the means of an early detection of BC recurrence. | Stephane Zervoudis George Iatrakis Eirini Tomara Anastasia Bothou George Papadopoulos George Tsakiris | 2014 | World Journal of Clinical Oncology2014，5，3： | 5 |
| 2 | Nipple discharge screening显示文摘 | Zervoudis S Iatrakis G Economides P | 2010 | Womens Health (Lond Engl)2010，6，1： | 1 |
| 3 | Nipple discharge screen-ing显示文摘 | Zervoudis S Iatrakis G Economides P | 2010 | Womens Health ( Lond Engl)2010，6，1： | 1 |
| 4 | Nipple discharge screening显示文摘 | Zervoudis S Iatrakis G Economides P | 2010 | Womens Health (Lond Engl)2010，6，1： | 1 |
| 5 | Polycystic ovarian syndrome, insulin resistance and thickness of the endometrium显示文摘 | Iatrakis G Tsionis C Adonakis G | 2006 | Eur J Obstet Gynecol Reprod Biol2006，127，： | 1 |
| 6 | Nipple discharge screening 显示文摘 | Zervoudis S Iatrakis G Economides P | 2011 | Women Health (Lond Engl)2011，6，1： | 1 |
| 7 | Polyeystic ovarian syn- drome, insulin resistance and thickness of the endometrium 显示文摘 | Iatrakis G Tsionis C Adonakis G | 2006 | Eur J Obstet Gynecol Reprod Biol2006，127，2： | 1 |
| 8 | Polycystic ovarian syndrome, insulin resistance and thickness of the endometrium显示文摘 | Iatrakis G Tsionis C Adonakis G | 2006 | Eur J Obstet Gynecol Reprod Biol2006，127，2： | 1 |
| 9 | Nipple discharge screening显示文摘 | Zervoudis S Iatrakis G Economides P | 2010 | Women''s Health(Lond Engl)2010，6，1： | 1 |
| 10 | Increased levels of tumor markers in the follow-up of 400 patients with breast cancer without recurrence or metastasis:interpretation of false-positive results显示文摘 | Zervoudis S Peitsidis P Iatrakis G | 2007 | J BUON2007，12，： | 1 |
| 11 | Reproduction after breast cancer显示文摘 | Zervoudis S Iatrakis G Navrozoglou I | 2010 | Best Pract Res Clin Obstet Gynaecol2010，24，1： | 1 |
| 12 | Women younger than 50 years with endometrial cancer 显示文摘 | Iatrakis G Zervoudis S Saviolakis A | 2006 | Eur J Gynaecol Oncol2006，27，4： | 1 |
| 13 | Quinagol- ide effects in normoprolactinemic galactorrhea 显示文摘 | ZERVOUDIS S IATRAKIS G GALAZIOS G | 2014 | Breast J2014，20，2： | 1 |
| 14 | Complementaty treatment with oral Pidotimod plus vitamin C after laser vaporization for female genital wart:a prospective study显示文摘 | Zervoudis S Iatrakis GPeitsidis P | 2010 | J Med Life2010，3，3： | 1 |
| 15 | Polycystic ovarian syndrome, insulin resistance and thickness of the endometrium 显示文摘 | Iatrakis G Tsionis C | 2006 | Eur J Obstet Gyneeol Reprod Biol2006，127，2： | 1 |
| 16 | Transnipple pyramidectomy in pathological nipple discharge:an original minimal surgery technique in a series of 80 cases显示文摘 | Zervoudis S Iatrakis G Navrozoglou I | | 0，，04： | 1 |
| 17 | Polycystic ovarian syndrome insulin resistance and thickness of the endometrium显示文摘 | Iatrakis G Tsionis C Adonakis G | 2006 | Eur J Obstet Gyneeol Rcprod Biot2006，127，2： | 1 |
| 18 | Nipple dischargescreening显示文摘 | ZERVOUDIS S IATRAKIS G ECONOMIDES P | 2010 | Womens Health (Lond Engl)2010，6，1： | 1 |
| 19 | Complementary treatment with oral pidotimod plus vitamin C after laser va- porization for female genital warts : a prospective study 显示文摘 | Zervoudis S Iatrakis G Peitsidis P | 2010 | Med Life2010，3，3： | 1 |
| 20 | Postmenopausal uterine bleeding 显示文摘 | Iatrakis G Diakakis I Kourounis G | 1997 | Clin Exp Obstet Gynecol1997，24，3： | 1 |
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