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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | Perturbations in the HDL metabolic pathway predispose to the development of osteoar- thritis in mice following long - term exposure to western - type diet 显示文摘 | Triantaphyllidou IE Kalyvioti E Karavia E | 2013 | Osteoarthritis Cartilage2013，21，： | 1 |
| 3 | Connective tissue growth faetor-a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats 显示文摘 | Ahmed MS O ie E Vinge LE | 2004 | J Mol Cell Cardiol2004，36，3： | 1 |
| 4 | Single-stage posterior veterbrectomy and replacement combinedwith posterior instrumentation for spinal metastasis显示文摘 | Akeyson E McCutcheon IE | 1996 | J Neurosurg1996，85，3： | 1 |
| 5 | Induction of myocardial connective tissue growth factor in pacing-induced heart failure in pigs 显示文摘 | Ahmed MS von Lueder TG ?ie E | 2005 | Acta Physiol Scand2005，184，1： | 1 |
| 6 | Difference in DNA fragmenta- tion following transient cerebral or decapitation ischemia in rats显示文摘 | MacManas JP Hill IE Preston E | 1995 | J Cereb Blood flow Metab1995，15，5： | 1 |
| 7 | Reversible sple- nial lesion syndrome ( I!ESLES ) : what' s in a name? 显示文摘 | Garcia-Monco JC Cortina IE Ferreira E | 2011 | J Neuroimaging2011，21，2： | 1 |
| 8 | Open, randomized muhicenter comparative trial of rabeprazole, ofloxacin and amoxicillin therapy for Helicobater pylori eradication ;7 vs 14 day treatment 显示文摘 | OBSQUES-PADILLA FJ GARZA-GONZALEZ E CALDERONLOZANO IE | 2004 | Helicobacter2004，9，5： | 1 |
| 9 | Tidal Wetland Record of Holocene Sea-LevelMovements and Climate History 显示文摘 | Fletcher IE C H Van Pelt J E Brush G S | 1993 | Palaeogeography Palaeoclimatology Palaeoecology1993，102，： | 1 |
| 10 | Profile-Based String Kernels for Remote Homology Detection and Motif Extraction显示文摘 | Kuang R Ie E Wang K | 2005 | Journal of Bioinformatics and Computational Biology2005，3，3： | 1 |
| 11 | Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy显示文摘 | Connick E Kane MA White IE | | 0，，： | 1 |
| 12 | Reduction in haemoglobin after knee joint replacement surgery显示文摘 | Pattison E Protheroe K Pring Ie R | 1973 | J Ann Rheumdis1973，32，6： | 1 |
| 13 | Isoxida tive stress the pathogenic mechanism underlying insulin resistance,diabetes,and cardiovascu lar disease The common soil hypothesis revisited显示文摘 | Cer ie llo A Mo tz E | 2004 | A rterioscler Thromb Vasc Biol2004，24，5： | 1 |
| 14 | Adnexal masses in pregnancy显示文摘 | Schwartz N Timor-Tritsch IE Wang E | | 0，，04： | 1 |
| 15 | Evaluation of neutron dose in the maze of medical electron accelerators显示文摘 | Carinou E Kamenopoulou V Stamatelatos IE | 1999 | Med Phys1999，26，12： | 1 |
| 16 | Health-related quality of life and pouch function in continent ileostomy patients : a 30-year perspective显示文摘 | Berndtsson IE Lindholm E Oresland T | 2004 | Dis Colon Rectum2004，47，21： | 1 |
| 17 | Pi- lot trial of sunitinib therapy in patients with Von Hippel- Lindaudisease显示文摘 | Jonasch E McCutcheon IE Waguespack SG | 2011 | Ann Oncol2011，22，12： | 1 |
| 18 | Cryoextraetion:A novel ap- proach to remove aspirated chewing gum 显示文摘 | Rubio E Gupta P Ie S | 2013 | Annals of Thoracic Medicine2013，8，1： | 1 |
| 19 | Health-related quality of life and pouch function in continent ileostomy patients: a 30-year perspective 显示文摘 | Berndtsson IE Lindholm E | 2004 | Dis Colon Rectum2004，47，12： | 1 |
| 20 | Circulating soluble vascular adhesion,protein 1 in patients with inflammatory bowel disease显示文摘 | Koutroubakis IE Petinaki E Vardas E | 2002 | Eur J Gastroenterol Hepatol2002，14，： | 1 |
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