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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine显示文摘Hepatocellular carcinoma(HCC) is the leading primary liver cancer and its clinical outcome is still poor. MicroRNAs(mi RNAs) have demonstrated an interesting potential to regulate gene expression at post-transcriptional level. Current findings suggest that mi RNAs deregulation in cancer is caused by genetic and/or epigenetic, transcriptional and post-transcriptional modifications resulting in abnormal expression and hallmarks of malignant transformation: aberrant cell growth, cell death, differentiation, angiogenesis, invasion and metástasis. The important role of mi RNAs in the development and progression of HCC has increased the efforts to understand and develop mechanisms of control overt this single-stranded RNAs. Several studies have analyzed tumoral response to the regulation and control of deregulated mi RNAs with good results in vitro and in vivo, proving that targeting aberrant expression of mi RNAs is a powerful anticancer therapeutic. Identification of up and/or down regulated mi RNAs related to HCC has led to the discovery of new potential application for detection of their presence in the affected organism. Mi RNAs represent a relevant new target for diagnosis, prognosis and treatment in a wide variety of pathologic entities, including HCC. This manuscript intends to summarize current knowledge regarding mi RNAs and their role in HCC development. | Iván Lyra-González Laura E Flores-Fong Ignacio González-García David Medina-Preciado Juan Armendáriz-Borunda | 2015 | World Journal of Hepatology2015，7，11： | 9 |
| 3 | Supply chain optimization in continuous flexible process networks显示文摘 | Jin-Kwang Bok Ignacio E Grossmann Sunwon Park | 2000 | Ind Eng Chem Res2000，39，5： | 2 |
| 4 | Design of Distillation Sequences:from Conventional to Fully Thermally Coupled Distillation System显示文摘 | José A Caballero Ignacio E Grossmann | 2004 | Computers and Chemical Engineering2004，28，： | 1 |
| 5 | Ethanol production from steam-explosion pretreated wheat straw显示文摘 | IGNACIO BALLESTEROS MA JOS(E) NEGRO JOS(E) MIGUEL OLIVA | 2006 | Applied Biochemistry and Biotechnology2006，130，13： | 1 |
| 6 | A systematic modeling framework of superstructure optimization in process synthesis 显示文摘 | Yeomans Hector Ignacio E | 1999 | Computers&Chemical Engineering1999，23，： | 1 |
| 7 | Kinetic studies on the anaerobic degradation of soluble and particulate matter in potato wastewater 显示文摘 | Ignacio Durruty Noemi E Zaritzky Jorge F Gonzalez | 2012 | Biosystems Engineering2012，，2： | 1 |
| 8 | Optimum startingup protocol of a pilot plant scale acetifier for vinegar production显示文摘 | Ignacio deory Luis E Domingo Cantero | | 0，，： | 1 |
| 9 | Con'osion Protection of Carbon Steel with Thermoplastic Coatings and Alkyd Res- ins Containing Polyaniline as Conductive Polymer 显示文摘 | JOS'E IGNACIO Iribarren Lacoa FRANCISCO Cadena Vil- lotab FRANCISCO Liesa Mestres | 2005 | Pro- gress in Organic Coatings2005，52，： | 1 |
| 10 | Early alterations in energy metabolism in the hippocampusof APPswe/PS 1 dE9 mouse model of Alzheimer’s disease显示文摘 | Ignacio Pedros Dmitry Petrov Michael Allgaier e/ al | 2014 | Biochim Biophys Acta2014，1842，9： | 1 |
| 11 | A model predictive control strategy for supply chain opti-mization显示文摘 | Edgar Perea-Lopez B Erik Ydstie Ignacio E Grossmann | 2003 | Computers and Chemical Engineering2003，27，： | 1 |
| 12 | Integration of Utilities Infrastructures in a Future Internet Enabled Smart City Framework 显示文摘 | Luis S 6 nchez Ignacio E Javier C | 2013 | Sensors2013，13，14： | 1 |
| 13 | A structural optimization approach in process synthesis (Ⅰ):Utility systems显示文摘 | Papoulias Soterios A Grossmann Ignacio E | | 0，，06： | 1 |
| 14 | Phylogeny of hydradephagan water beetles inferred from 18S rRNA sequences 显示文摘 | IGNACIO R JAMES E H VOGLER A P | 2002 | Mol Phylogenet Evo12002，23，1： | 1 |
| 15 | A Decomposition Approach for the Scheduling of a Steel Plant Production显示文摘 | Iiro Harjunkoski Ignacio E Grossmann | 2001 | Computers and Chemical Engineering2001，25，1112： | 1 |
| 16 | Conceptual framework for combining artificial intelligence and optimization in engineering design 显示文摘 | CAGAN Jonathan GROSSMANN E Ignacio HOOKER John | 1997 | Research in Engineering Design-Theory Applications and Concurrent Engineering1997，9，1： | 1 |
| 17 | Poly- (silsesquioxanes) derived from the ydrolytic condensation of organotrialkoxysilanes containing hydroxyl groups显示文摘 | IGNACIO E D E DIANA P F ROBERTO J J W | 2003 | J Org Metal Chem2003，686，12： | 1 |
| 18 | Nannochloropsis (Eustigmatophyceae) as source of commercially valuable pigment显示文摘 | Lubian L M Olimpio Montero Ignacio Moreno-Garrido Huertas I E Cristina Sobrino Manuel Gonzalez-del Valle Griselda Pares | 2000 | Journal of AppliedPhycology2000，12，： | 1 |
| 19 | A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge 显示文摘 | Llilianne Ganges Maritza Barrera Jos e Ignacio N u ez | 2005 | Vaccine2005，23，28： | 1 |
| 20 | Moni- toring and prediction of fouling in coal-fired utility boilers using neural networks显示文摘 | TERUEL E CORTES C IGNACIO DIEZ L | 2005 | Chemical Engineering Science2005，60，18： | 1 |
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