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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Robust Array Beamforming with Sidelobe Control Using Support Vector Machines 显示文摘 | Cesar C G Ignacio S Javier V | 2007 | IEEE Trans on Signal Processing2007，55，2： | 1 |
| 3 | Robust array beam- forming wit h sidelobe cont rolusing support vector machines 显示文摘 | Cesar C G Ignacio S J avier V | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 4 | Robust array beamforming with sidelobe control using support vector machines显示文摘 | CESAR C G JAVIER V IGNACIO S | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 5 | Manage- ment innovation and leadership: the moderating role of organizational size 显示文摘 | Ignacio G V Justin J P J Frans A J V | 2012 | Journal of Management Studies2012，1，49： | 1 |
| 6 | Intestinal, probiotics, and cirrhosis 显示文摘 | IGNACIO G H ALDO T D FLORENCIA V V | 2008 | Annals Hepatol2008，7，2： | 1 |
| 7 | Differences between carbon nanofibers produced using Fe and Ni catalysts in a floating catalyst reactor 显示文摘 | IGNACIO M G JOSE V JUAN A C JOSE L G | 2006 | Carbon2006，44，8： | 1 |
| 8 | Determination of lead and cadmium using an ionic liquid and dispersive liquid -liquid microextraction followed by electrothermal atomic absorption spectrometry 显示文摘 | Ignacio L G Yesica V M Manuel H C | 2013 | Talanta2013，110，： | 1 |
| 9 | Robust Array Beamformingwith Sidelobe Control Using Support Vector Machines显示文摘 | Cesar C G Javier V Ignacio S | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 10 | Acomparative evaluation of microalgae for the degrada-tion ofpiggery wastewater under photosynthetic oxygenation 显示文摘 | IGNACIO D G VIRGINIA A V SAUL B | 2010 | Bioresource Technology2010，101，14： | 1 |
| 11 | Robust array beamforming with sidelobe control using support vector machines显示文摘 | Cesar C G Ignacio S Javier V | 2007 | IEEE Trans Signal Processing2007，55，2： | 1 |
| 12 | Fire hazard in bridges:review, assessment and repair strate- gies 显示文摘 | MARIA G IGNACIO P Z KODUR V K R | 2012 | Engineering Structures2012，35，1： | 1 |
| 13 | Fire Haz-ard in Bridges: Review, Assessment and Repair Strat- egies显示文摘 | Maria G Ignacio P Z Kodur V K R etal | 2012 | Engineering Structures2012，35，1： | 1 |
| 14 | Fire Hazard in Bridges:Review,Assessment and Repair Strategies显示文摘 | Maria G Ignacio P Z Kodur V K R | 2012 | Engineering Structures2012，35，1： | 1 |
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