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| 1 | Fecal stream diversion and mucosal cytokine levels in collagenous colitis:A case report显示文摘In this case report, we examined the levels of cytokines expressed before and during fecal stream diversion and after intestinal continuity was restored in a patient with collagenous colitis. We report the case of a46-year-old woman with chronic, active collagenous colitis who either failed to achieve clinical remission or experienced adverse effects with the following drugs:loperamide, cholestyramine, budesonide, methotrexate and adalimumab. Due to the intractable nature of the disease and because the patient was having up to 15 watery bowel movements per day, she underwent a temporary ileostomy. Colonic biopsies were analyzed for mucosal cytokine protein levels before and during fecal stream diversion and after intestinal continuity was restored. Mucosal protein levels of interleukin(IL)-1β,IL-2, IL-6, IL-12, IL-17 A, IL-23, TNF, IFN-γ, IL-4, IL-5,IL-10 and IL-13 were all higher during active disease and decreased to non-detectable or considerably lower levels during fecal stream diversion. One month after the restoration of bowel continuity, when the patient experienced a relapse of symptoms, IL-2, IL-23 and IL-21 levels were again increased. Our results indicate that fecal stream diversion in this patient suppressed the levels of all cytokines analyzed in colonic biopsies. With the recurrence of clinical symptoms and histological changes after bowel reconstruction,the levels of primarily proinflammatory cytokines increased. Our findings support the hypothesis that a luminal factor triggers the inflammation observed in collagenous colitis. | Niki Daferera Ashok Kumar Kumawat Elisabeth Hultgren-Honquist Simone Ignatova Magnus Strom Andreas Münch | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 2 | Preparative isolation and purification of ginsenosides Rf, Re, Rd and Rbl from the roots of Panax ginseng with a salt/containing solvent system and flow step-gradient by high performance counter-current chromatographycoupled with an evaporative light scattering detector 显示文摘 | Qi X C Ignatova S Luo G A | 2010 | J Chro- matogrA2010，1217，15： | 1 |
| 3 | Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres显示文摘 | Suslov ON Kukelov VG Ignatova TN | 2002 | Pro Natl Acad Sci USA2002，99，14： | 1 |
| 4 | Multiple dual-mode countercurrent chromatography applied to chiral separations using a(S)-naproxen derivative as chiral selector显示文摘 | RUBIO N IGNATOVA S MINGUILLON C | 2009 | J Chromatogr A2009，1216，48： | 1 |
| 5 | Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro 显示文摘 | Ignatova TN Kukekov VG Laywell ED | 2002 | Glia2002，39，3： | 1 |
| 6 | Development of a strategy and process parameters for a green process in counter-current chromatography; purification of tanshinone Ⅱ A and cryptotanshinone from Salvialx miltiorrhiza Bunge as a case study 显示文摘 | ZHANG M IGNATOVA S HU P | 2011 | J Chromatogr A2011，1218，36： | 1 |
| 7 | Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro 显示文摘 | Ignatova TN Kukekov VG Laywell ED | 2002 | Glia2002，39，3： | 1 |
| 8 | Glucooligosaccharides synthesized by glucosyltransferases from constitutive mutants of Leuconostocmesenteroides strain Lm28显示文摘 | Iliev I Vassileva T Ignatova C | 2008 | Journal of applied microbiology2008，104，1： | 1 |
| 9 | Drug-loaded electrospun materials in wound-dressing applications and in local cancer treatment显示文摘 | Ignatova M Rashkov I Manolova N | 2013 | Expert Opin Drug Deliv2013，10，4： | 1 |
| 10 | Isolation and partial characterization of extracellular keratinase from a wool degrading thermophilic actinomycete strain Therno actinomyces candidus 显示文摘 | Ignatova Z Gousterovw A Spassov G | 1999 | Can J Microbiol1999，45，3： | 1 |
| 11 | Glial tumors contain neural stem 2 like cells expressing as troglial and neuronal markers in vitro显示文摘 | Ignatova TN Kukekov VG Laywell ED | 2002 | Glia2002，39，3： | 1 |
| 12 | Check list of mosses of East Europe and North Asia显示文摘 | IGNATOV M S AFONINA O M IGNATOVA E A | 2006 | Arctoa2006，15，130： | 1 |
| 13 | Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins显示文摘 | Prabhu S Ignatova A Park ST | 1997 | Mol Cell Biol1997，17，10： | 1 |
| 14 | Tumor necrosisfactor-alpha upregulates 11 beta-hydroxysteroid dehydrogenase type 1expression by CCAAT/enhancer binding protein-beta in HepG2 cells显示文摘 | Ignatova ID Kostadinova RM Goldring CE | 2009 | Am J Physiol Endocrinol Metab2009，296，2： | 1 |
| 15 | Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase:biochemical and immunofluorescence confocal microscopic evidence显示文摘 | Belcheva MM Bohn LM | 1999 | J Neurosci1999，19，1： | 1 |
| 16 | Isolation and partial characterization of extracellular keratinase from a wool degraging thermophilic actimomycete strain Thermoatinoc atinomyces candidus 显示文摘 | Ignatova Z Gousterova A Spassov G Nedkov P | 1999 | Canadian Microbiol1999，45，3： | 1 |
| 17 | Review of progress toward the industrial scale-up of CCC显示文摘 | Sutherland I Hawes D Ignatova S | 2005 | J liq Chromatogr Relat Technol2005，28，： | 1 |
| 18 | Design of an tibacterial surfaces by a combination of electrochemis try and controlled radical polymerization 显示文摘 | Voccia S Ignatova M Jerome R | 2006 | Lang muir2006，22，： | 1 |
| 19 | Preparative isolationand purification of ginsenosides Rf, Re, Rd and Rb} fromthe roots of Panax ginseng with a salt/containing solventsystem and flow step-gradient by high performancecounter-current chromatography coupled with anevaporative light scattering detector 显示文摘 | Qi X C Ignatova S Luo G A | 2010 | J Chromatogr A2010，1217，13： | 1 |
| 20 | Combination of electrografting and atom-transfer radical polymerization for making the stainless steel surface antibacterialand protein antiadhesive显示文摘 | Ignatova M Voccia S Gilbert B | 2006 | Langmuir2006，22，1： | 1 |
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