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| 1 | Non-variceal upper gastrointestinal bleeding: Rescue treatment with a modified cyanoacrylate显示文摘AIM To evaluate the safety and efficacy of a modified cyanoacrylate [N-butyl-2-cyanoacrylate associated with methacryloxysulfolane(NBCA + MS)] to treat nonvariceal upper gastrointestinal bleeding(NV-UGIB).METHODS In our retrospective study we took into account 579 out of 1177 patients receiving endoscopic treatment for NV-UGIB admitted to our institution from 2008 to 2015; the remaining 598 patients were treated with other treatments. Initial hemostasis was not achieved in 45 of 579 patients; early rebleeding occurred in 12 of 579 patients. Thirty-three patients were treated with modified cyanoacrylate: 27 patients had duodenal, gastric or anastomotic ulcers, 3 had post-mucosectomy bleeding, 2 had Dieulafoy's lesions, and 1 had duodenal diverticular bleeding.RESULTS Of the 45 patients treated endoscopically without initialhemostasis or with early rebleeding, 33(76.7%) were treated with modified cyanoacrylate glue, 16(37.2%) underwent surgery, and 3(7.0%) were treated with selective transarterial embolization. The mean age of patients treated with NBCA + MS(23 males and 10 females) was 74.5 years. Modified cyanoacrylate was used in 24 patients during the first endoscopy and in 9 patients experiencing rebleeding. Overall, hemostasis was achieved in 26 of 33 patients(78.8%): 19 out of 24(79.2%) during the first endoscopy and in 7 out of 9(77.8%) among early rebleeders. Two patients(22.2%) not responding to cyanoacrylate treatment were treated with surgery or transarterial embolization. One patient had early rebleeding after treatment with cyanoacrylate. No late rebleeding during the follow-up or complications related to the glue injection were recorded.CONCLUSION Modified cyanoacrylate solved definitively NV-UGIB after failure of conventional treatment. Some reported life-threatening adverse events with other formulations, advise to use it as last option. | Roberto Grassia Pietro Capone Elena Iiritano Katerina Vjero Fabrizio Cereatti Mario Martinotti Gabriele Rozzi Federico Buffoli | 2016 | World Journal of Gastroenterology2016，22，48： | 8 |
| 2 | Neuroendocrine carcinomas arising in ulcerative colitis:Coincidences or possible correlations?显示文摘Patients with in· ammatory bowel disease (IBD) are at increased risk of colorectal malignancies. Adenocarcinoma is the commonest type of colorectal neoplasm associated with ulcerative colitis (UC) and Crohn's disease, but other types of epithelial and non-epithelial tumors have also been described in inflamed bowel. With regards to non-epithelial malignancies, lymphomas and sarcomas represent the largest group of tumors reported in association with IBD, especially in immunosuppressed patients. Carcinoids and in particular neuroendocrine neoplasms other than carcinoids (NENs) are rare tumors and are infrequently described in the setting of IBD. Thus, this association requires further investigation. We report two cases of neoplasms arising in mild left-sided UC with immuno-histochemical staining for neuroendocrine markers: a large cell and a small cell neuroendocrine carcinoma of the rectum. The two patients were different in age (35 years vs 77 years) and disease duration (11 years vs 27 years), and both had never received immuno-suppressant drugs. Although the patients underwent regular endoscopic and histological follow-up, the two neoplasms were locally advanced at diagnosis. One of the two patients developed multiple liver metastases and died 15 mo after diagnosis. These findings confirm the aggressiveness and the poor prognosis of NENs compared to colorectal adenocarcinoma. While carcinoids seem to be coincidentally associated with IBD, NENs may also arise in this setting. In fact, long-stand-ing in· ammation could be directly responsible for thedevelopment of pancellular dysplasia involving epithelial, goblet, Paneth and neuroendocrine cells. It has yet to be established which IBD patients have a higher risk of developing NENs. | Roberto Grassia Paolo Bodini Paolo Dizioli Teresa Staiano Elena Iiritano Guglielmo Bianchi Federico Buffoli | 2009 | World Journal of Gastroenterology2009，15，33： | 4 |
| 3 | Endoscopic “retroperitoneal fatpexy” of a large ERCP-related jejunal perforation by using a new over–the-scope clip device in Billroth II anatomy (with video)显示文摘 | Federico Buffoli Roberto Grassia Elena Iiritano Guglielmo Bianchi Paolo Dizioli Teresa Staiano | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 4 | Pseudogene-mediatedposttranscriptional silencing of HMGA1 can result in insulin resist- ance and type 2 diabetes显示文摘 | Chiefari E Iiritano S Paonessa F | 2010 | Nat Commun2010，1，： | 1 |
| 5 | The HMGA1-IGF-I/IGFBP System: A Novel Pathway for Modulating Glucose Uptake显示文摘 | Stefania Iiritano Eusebio Chiefari Valeria Ventura Biagio Arcidiacono Katiuscia Possidente Aurora Nocera Maria T. Nevolo Monica Fedele Adelaide Greco Manfredi Greco Giuseppe Brunetti Alfredo Fusco Daniela Foti Antonio Brunetti | 2012 | Molecular Endocrinology2012，，9： | 1 |
| 6 | Treatment of radiation-induced hemorrhagic gastritis with endoscopic band ligation显示文摘 | Teresa Staiano Roberto Grassia Elena Iiritano Guglielmo Bianchi Paolo Dizioli Federico Buffoli | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 7 | Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet显示文摘 | Zentilin P Iiritano E Dulbecco P | 2006 | Dig Liver Dis2006，38，4： | 1 |
| 8 | Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet显示文摘 | Zentilin P Iiritano E Dulbecco P | 2006 | Dig Liver Dis2006，38，4： | 1 |
| 9 | Insulin resistance and cancer risk:an overview of the pathogenetic mechanisms显示文摘 | Arcidiacono B Iiritano S Nocera A | 2012 | Exp Diabetes Res2012，2012，78： | 1 |
| 10 | Insulin resistance and cancer risk:an overview of the pathogenetic mechanisms显示文摘 | Arcidiacono B Iiritano S Nocera A | | 0，，： | 1 |
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