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| 1 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 2 | Experimental Studies on Thermal and Electrical Properties of Platinum Nanofilms显示文摘我们试验性地在 15nm 的厚度学习了热的在里面飞机和推迟的铂 nanofilm 的电的性质。测量结果证明 in-planethermal 传导性,电的传导性和学习 nanofilm 的抵抗温度系数多不到那些体积材料,当 Lorenz 数字比体积大时,珍视。与结果作比较在 28nm 的厚度为铂 nanofilm 以前报导了,我们进一步发现在里面飞机热电导率,电的传导性和抵抗温度系数与 nanofilm 的减少的厚度减少,当 Lorenz 数字与 nanofilm 的减少的厚度增加时。Theseresults 显示强壮的尺寸效果在在里面飞机上存在铂 nanofilms 的热、电的性质。 | 张兴 张清光 曹炳阳 FUJII Motoo TAKAHASHI Koji IKUTA Tatsuya | 2006 | Chinese Physics Letters2006，23，4： | 5 |
| 3 | Iron overload and cofactors with special reference to alcohol,hepatitis C virus infection and steatosis/insulin resistance显示文摘有几个余因子,影响身体铁新陈代谢并且加速铁超载。酒精和肝的病毒的感染是为在铁超载澄清余因子的角色的最典型的例子。处于这些条件,铁在房间和通过 Fenton 反应生产的反应的氧种类(ROS ) 有的 hepatocytes 和 Kupffer 被扔便于 transferrin 固定的铁的细胞的举起的关键角色。而且, hepcidin,主要在肝生产的抗菌剂肽为肠的铁吸收和网状内皮组织的铁版本也负责。在有血浆铜蓝蛋白缺乏的病人,在肝和 neurodegeneration 的贫血症和第二等的铁超载被报导。而且,正在积累没有酒精和肥胖的脂肪酸累积自己修改铁超载状态的证据。无效红血球生成也是一个重要因素加速铁超载,它与象地中海贫血和 myelodysplastic 症候群那样的疾病被联系。当这个条件坚持时,饮食的铁吸收由于骨髓红血球生成的增长被增加,织物铁超载愿望此后发生。在迟发性皮肤卟啉症,铁是在肝积累的在第二。 | Yutaka Kohgo Katsuya Ikuta Takaaki Ohtake Yoshihiro Torimoto Junji Kato | 2007 | World Journal of Gastroenterology2007，13，35： | 4 |
| 4 | Preliminary Study to Identify Criterion for Quench Crack Prevention by Computer Simulation显示文摘A criterion for preventing quench cracks has not been established although much research has been conducted in this field. A few predictions of cracking have been recently reported using simulated results of heat treatment processes. However, these results were insufficient to predict crack generation clearly because the mechanism relates not only to stress distributions in the parts but also to material characteristics. Systematic studies by the combination of experiment and simulation are therefore required to reliably identify a criterion for crack prevention by computer simulation. As a preliminary work before starting the full-scale research, a review of quench cracking research was conducted and existing test methods were classified. Several test results for cylindrical specimens were simulated for considering a cause of the crack generation. Lastly a tentative plan was made for the future research. | Kyozo Arimoto Fumiaki Ikuta Takashi Horino Shigeyuki Tamura Michiharu Narazaki Yoshio Mikita | 2004 | 材料热处理学报2004，25，5： | 2 |
| 5 | Evolution of Invertebrate Deuterostomes and Hox/ParaHox Genes显示文摘Transcription factors encoded by Antennapedia-class homeobox genes play crucial roles in controlling development of animals, and are often found clustered in animal genomes.The Hox and ParaHox gene clusters have been regarded as evolutionary sisters and evolved from a putative common ancestral gene complex, the ProtoHox cluster, prior to the divergence of the Cnidaria and Bilateria (bilaterally symmetrical animals).The Deuterostomia is a monophyletic group of animals that belongs to the Bilateria,and a sister group to the Protostomia.The deuterostomes include the vertebrates(to which we belong),invertebrate chordates,hemichordates,echinoderms and possibly xenoturbellids,as well as acoelomorphs.The studies of Hox and ParaHox genes provide insights into the origin and subsequent evolution of the bilaterian animals.Recently,it becomes apparent that among the Hox and ParaHox genes,there are significant variations in organization on the chromosome,expression pattern,and function.In this review,focusing on invertebrate deuterostomes,I first summarize recent findings about Hox and ParaHox genes.Next,citing unsolved issues,I try to provide clues that might allow us to reconstruct the common ancestor of deuterostomes,as well as understand the roles of Hox and ParaHox genes in the development and evolution of deuterostomes. | Tetsuro Ikuta | 2011 | Genomics, Proteomics & Bioinformatics2011，9，3： | 2 |
| 6 | Effectiveness of impedance monitoring during radiofrequency ablation for predicting popping显示文摘AIM:To retrospectively evaluate the effectiveness of impedance monitoring for predicting popping during radiofrequency ablation(RFA) using internally cooled electrodes.METHODS:We reviewed 140 patients(94 males,46 females;age range 73.0 ± 11.1 year) who underwent RFA between February 2006 and November 2008 with a modified protocol using a limited power delivery rather than a conventional one to avoid popping.All the patients provided their written informed consent,and the study was approved by the institutional review board.Intraprocedural impedances were measured for the study subjects,and the tumors were classified into three types according to the characteristics of their impedance curves:increasing,flat,or decreasing.The tumors were further sorted into seven subtypes(A-G) depending on the curvature of the impedance curve' s increase or decrease.Relative popping rates were determined for the three types and seven subtypes.A chi-square test was performed to estimate statistical significance.RESULTS:A total of 148 nodules treated by RFA were analyzed.The study samples included 132 nodules of hepatocellular carcinoma,14 nodules of metastatic liver cancer,and two nodules of intrahepatic cholangiocarcinoma.The numbers of nodules with each impedance curve type were as follows:37 increasing-type nodules,43 flat-type nodules,and 68 decreasing-type nodules.Popping occurrence rates were 24.3%,46.5% and 64.7%,respectively.Flat-type nodules exhibited a significantly higher rate of popping compared to increasing-type nodules(P = 0.039).Decreasing-type nodules exhibited a significantly higher rate of popping compared to increasing-type nodules(P < 0.0001).Notably,nodules that showed a sharp decrease in impedance in the latter ablation period(subtype E) exhibited a significantly higher rate of popping compared to other subtypes.CONCLUSION:Intraprocedural impedance monitoring can be a useful tool to predict the occurrence of popping during liver tumor RFA performed with internally cooled electrodes. | Hiroya Iida Tsukasa Aihara Shinichi Ikuta Naoki Yamanaka | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 7 | Molecular characterization of brazilian infectious bursal disease virus 显示文摘 | Ikuta N Attrache JEL Villegas P | 2001 | Avian Disease2001，45，： | 1 |
| 8 | Promotor hypermethy- lation of pl4ARF is a key alteration for progression of oral squamous cell carcinoma 显示文摘 | Ishida E Nakamura M Ikuta M | 2005 | Oral Oncol2005，41，6： | 1 |
| 9 | Detection of epsteinbarr virus in salivas and throat washings in healthy adults and children 显示文摘 | Ikuta K Satoh Y Hoshikawa Y | 2000 | Microbes and Infection2000，2，2： | 1 |
| 10 | (2006) Current status and perspective of angiogenesis and antivascular therapeutic strategy: Non small cell lung cancer显示文摘 | Yano S Matsumori Y Ikuta K | 2006 | International Journal of Clinical Oncology2006，11，2： | 1 |
| 11 | The use of autologous blood in the surgical treatment of spinal disorders 显示文摘 | Oga M Ikuta H Sugioka Y | 1992 | Spine1992，17，13： | 1 |
| 12 | Tissue inhibitor of metalloproteinase-1 in the liver of patients with chronic liver disease显示文摘 | Murawaki Y Ikuta Y Idobe Y | 1997 | J Heptol1997，26，6： | 1 |
| 13 | Mechanism of electrode surface damage and material removal in high current discharges显示文摘 | Watson A Donaldson A Ikuta K | | 0，，06： | 1 |
| 14 | 12- O -Tetradecanoylphorbol-13-acetate Induces Epstein–Barr Virus Reactivation via NF-κB and AP-1 as Regulated by Protein Kinase C and Mitogen-Activated Protein Kinase显示文摘 | Xiangrong Gao Kazufumi Ikuta Masako Tajima Takeshi Sairenji | 2001 | Virology2001，，： | 1 |
| 15 | Cy clability and dissolution of manganese i n substituted stoichiometric and non-sto ichiometric lithium manganese oxides at high temperature 显示文摘 | IKUTA H WAKIHARA M | 2000 | Electrochemistry2000，68，6： | 1 |
| 16 | Triterpenoids of Paeonia japonica callussue 显示文摘 | Ikuta A Itokawa H | 1988 | Phytochemistry1988，27，9： | 1 |
| 17 | The spinel phases LiM(y) nn(2-y) 0(4) ( M = Co, Cr, Ni) as the cathode for rechargeable lithium batteries 显示文摘 | Li G H Ikuta H Uchida T | 1996 | J Electrochem Soc1996，143，1： | 1 |
| 18 | Singel phase region of cation substituted spinel LiMyMn2- yO4-δ( M = Cr, Co and Ni) and cathode pro-perty for lithium secondary battery显示文摘 | Hosoya M Ikuta H Wakihara M | 1998 | Solid State Ionics1998，111，12： | 1 |
| 19 | Spinel phases LiAlyMn2-yO4(y=0,1/12,1/9,1/6,1/3) and Li(Al,M)1/6Mn11/6O4(M = Cr,Co) as the cathode for rechargeable lithium batteries显示文摘 | Song D Ikuta H Uchida T | 1999 | Solid State Ionics1999，117，12： | 1 |
| 20 | Chronic liver disease increa- ses the risk of linezolid-related thrombocytopenia in methicillin- resistant Staphylococcus aureus-infected patients after digestive surgery显示文摘 | Ikuta S Tanimura K Yasui C | 2011 | J Infect Chemother2011，17，3： | 1 |
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