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| 1 | Impact of comorbidities on the severity of chronic hepatitis B at presentation显示文摘AIM:To evaluate the clinical relevance of each cofactor on clinical presentation of chronic hepatitis B.METHODS:Out of 1366 hepatitis B surface antigen(HBsAg) positive subjects consecutively observed in 79 Italian hospitals,53(4.3%) showed as the only cofactor hepatitis D virus(HDV) infection [hepatitis B virus(HBV)/HDV group],130(9.5%) hepatitis C virus(HCV)(group HBV/HCV),6(0.4%) human immunodeficiencyvirus(HIV)(group HBV/HIV),138(10.2%) alcohol abuse(group HBV/alcohol);109(8.0%) subjects had at least two cofactors and 924 were in the cofactor-free(CF) group.RESULTS:Compared with patients in group CF those in group HBV/alcohol were older and more frequently had cirrhosis(P < 0.001),those in group HBV/HDV were younger(P < 0.001),more frequently resided in the south of the country and had cirrhosis(P <0.001),those in group HBV/HCV were older(P < 0.001) and more frequently had cirrhosis(P < 0.001).These cofactors were all independent predictors of liver cirrhosis in HBsAg positive patients.Multivariate analysis showed that an older age [odds ratio(OR) 1.06,95% CI:1.05-1.08],alcohol abuse with more than 8 drinks daily(OR 2.89,95% CI:1.81-4.62) and anti-HDV positivity(OR 3.48,95% CI:2.16-5.58) are all independently associated with liver cirrhosis.This association was found also for anti-HCV positivity in univariate analysis,but it was no longer associated(OR 1.23,95% CI:0.84-1.80) at multivariate analysis.CONCLUSION:Older age,HDV infection and alcohol abuse are the major determinants of severe liver disease in chronic HBV infection,while HCV replication plays a lesser role in the severity of hepatic damage. | Evangelista Sagnelli Tommaso Stroffolini Alfonso Mele Michele Imparato Caterina Sagnelli Nicola Coppola Piero Luigi Almasio | 2012 | World Journal of Gastroenterology2012，18，14： | 4 |
| 2 | Effect of drying time and the presence of plaque on the in vitro performance of laser florescence in occlusal caries of primary teeth显示文摘 | Mendes FM Hissadomi M Imparato JC | 2004 | Caries Res2004，38，2： | 1 |
| 3 | The cause of perioperative stroke after carotid endarterectomy显示文摘 | Riles TS Imparato AM Jacobowits GR | 1994 | J Vasc Surg1994，19，2： | 1 |
| 4 | A new strategy of treatment with low-dosage acetyl salicylic acid in patients affected by central serous chorioretinopathy显示文摘 | Antonio Caccavale Manuela Imparato Filippo Romanazzi Angelo Negri Alessandro Porta Fabio Ferentini | 2009 | Medical Hypotheses2009，，： | 1 |
| 5 | Differential diagnosis and management of focal ground-glass opacities显示文摘 | Infante M Lutman RF Imparato S | 2009 | Eur Respir J2009，33，： | 1 |
| 6 | Anti- bacterial activity of glass-ionomer cement containing antibi- otics on caries lesion microorganisms 显示文摘 | Pinheiro SL Simionato MR Imparato JC & Oda M | 2005 | Am J Dent2005，18，4： | 1 |
| 7 | A new strategy of treatment with low-dosage acetyl salicylic acid in patients affected by central serous chorioretinopathy 显示文摘 | Caccvale A Imparato M Romanazzi F | 2009 | Med Hypotheses2009，73，： | 1 |
| 8 | The cause of perioperative stroke after carotid endarterectomy显示文摘 | Riles TS Imparato AM Jacobowitz GR | 1994 | J Vasc Surg1994，19，2： | 1 |
| 9 | Long-term results of sigmoid vaginoplasty in a consecutive series of 62 patients显示文摘 | IMPARATO E ALFEI A ASPESI G | 2007 | Int Urogynecol J Pelvic Floor Dysfunct2007，18，12： | 1 |
| 10 | Doppler derived mitral deceleration time of early filling as a strong predictor of pulmonary capillary wedge pressure in postinfarction patients with left ventricular systolic dysfunction显示文摘 | Giannuzzi P Imparato A Temporelli PL | 1994 | J Am Coll Cardiol1994，23，： | 1 |
| 11 | Long-term results of sigmoid vaginoplasty in a consecutive series of 62 pa- tients显示文摘 | Imparato E Alfei A Aspesi G | 2007 | Int Urogynecol J Pelvic Floor Dysfunct2007，18，12： | 1 |
| 12 | Long-term results of sigmoid vaginoplasty in a consecutiveseries of 62patients显示文摘 | Imparato E Alfei A Aspesi G | 2007 | Int Urogynecol J Pelvic Floor Dysfunct2007，18，12： | 1 |
| 13 | Short-term resource scheduling in multi-area hydrothermal power systems 显示文摘 | Ferreira L A F M Andersson T Imparato C F | 1989 | Electrical Power and Energy Systems1989，11，3： | 1 |
| 14 | A new strategy of treatment with low-dosage acetyl salicylic acid in patients affected by central serous chofioretinopathy显示文摘 | Caccavale A Imparato M Romanazzi F | 2009 | Med Hypotheses2009，73，： | 1 |
| 15 | The cause of penoperative storke after carotid endarterectomy显示文摘 | Riles TS Imparato AM Jacobowitz GR | 1994 | J Vasc Sug1994，19，2： | 1 |
| 16 | Differential diagnosis and management of focal ground-glass opacities显示文摘 | M Infante RF L utman S Imparato | 2009 | Eur Respir2009，33，4： | 1 |
| 17 | A new strategy of treatment with low-dosage acetyl salicylic acid in patients affected by central serous chorioretinopathy显示文摘 | Caccavale A Imparato M Romanazzi F | 2009 | Med Hypotheses2009，73，： | 1 |
| 18 | Cervical vertebral angioplasty for brain stem ischemia 显示文摘 | Imparato AM Riles TS Kim GE | 1981 | Surgery1981，90，5： | 1 |
| 19 | Angiographic criteria for successful tibial arterial reconstructions显示文摘 | | 1973 | Surgery1973，74，： | 1 |
| 20 | A new strategy of treatmentwith low-dosageacetyl salicylicacid in patientsaffeetedby centralsereus chorioretinopathy 显示文摘 | Caccavale A Imparato M Romanazzi F | 2009 | Med Hypotheses2009，73，3： | 1 |
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