5篇
您的检索式：作者名="In Kyung Rhee"
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| 1 | Mitochondria as therapeutic targets for cancer stem cells显示文摘Cancer stem cells(CSCs) are maintained by theirsomatic stem cells and are responsible for tumor initiation, chemoresistance, and metastasis. Evidence for the CSCs existence has been reported for a number of human cancers. The CSC mitochondria have been shown recently to be an important target for cancer treatment, but clinical significance of CSCs and their mitochondria properties remain unclear. Mitochondriatargeted agents are considerably more effective compared to other agents in triggering apoptosis of CSCs, as well as general cancer cells, via mitochondrial dysfunction. Mitochondrial metabolism is altered in cancer cells because of their reliance on glycolytic intermediates, which are normally destined for oxidative phosphorylation. Therefore, inhibiting cancer-specific modifications in mitochondrial metabolism, increasing reactive oxygen species production, or stimulating mitochondrial permeabilization transition could be promising new therapeutic strategies to activate cell death in CSCs as well, as in general cancer cells. This review analyzed mitochondrial function and its potential as a therapeutic target to induce cell death in CSCs. Furthermore, combined treatment with mitochondriatargeted drugs will be a promising strategy for the treatment of relapsed and refractory cancer. | In Sung Song Jeong Yu Jeong Seung Hun Jeong Hyoung Kyu Kim Kyung Soo Ko Byoung Doo Rhee Nari Kim Jin Han | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 2 | Anticoagulant activity of ilexoside D, a triterpenoid saponin fromIlex pubescens显示文摘 | Yong Nam Han Jae-Ihn Song In Kyung Rhee | 1993 | Archives of Pharmacal Research1993，，3： | 1 |
| 3 | Anti-inflammatory effects of a combined herbal prepara-tion(RAH13) of Phellodendron amurense and Coptischinensis in animal models of inflammation显示文摘 | Eun Kyung Park Hae In Rhee’Hye Sook Jung | 2007 | Phytother-apy Research August2007，21，8： | 1 |
| 4 | Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining显示文摘 | In Kyung Rhee Van de Meent M Ingkaninan K | 2001 | Journal of Chromatography A2001，915，12： | 1 |
| 5 | Procedure-related musculoskeletal symptoms in gastrointestinal endoscopists in Korea显示文摘AIM: To determine the prevalence and risk factors of work-related musculoskeletal disorders in gastrointestinal endoscopists in Korea. METHODS: A survey of musculoskeletal symptoms, using a self-administered questionnaire, was conducted on 55 endoscopists practicing in general hospitals or health promotion centers. RESULTS: Forty-nine (89.1%) endoscopists reported musculoskeletal pain on at least one anatomic location and 37 (67.3%) endoscopists complained of pain at rest. Twenty-six (47.3%) endoscopists had severe musculoskeletal pain defined as a visual analogue score greater than 5.5. Factors related to the development of severe pain were (1) standing position during upper endoscopy, (2) specific posture/ habit during endoscopic procedures, and (3) multiple symptomatic areas. Finger pain was more common in beginners, whereas shoulder pain was more common in experienced endoscopists. Sixteen percent of symptomatic endoscopists have modified their practice or reduced the number of endoscopic examinations. Only a few symptomatic endoscopists had sought professional consultation with related specialists. CONCLUSION: The prevalence of musculoskeletal pain in endoscopists is very high. The location of pain was different between beginners and experienced endoscopists. Measures for the prevention and adequate management of endoscopy-related musculoskeletal symptoms are necessary. | Young Hye Byun Jun Haeng Lee Moon Kyung Park Ji Hyun Song Byung-Hoon Min Dong Kyung Chang Young- Ho Kim Hee Jung Son Poong-Lyul Rhee Jae J Kim Jong Chul Rhee Ji Hye Hwang Dong Il Park Sang Goon Shim In Kyung Sung | 2008 | World Journal of Gastroenterology2008，14，27： | 1 |
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