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| 1 | Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence显示文摘BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is questionable.Artificial intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after PD.AIM To develop a risk prediction platform for POPF using an AI model.METHODS Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven algorithms.The algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing values.The area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF prediction.RESULTS The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition 2016.After median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with NN.The maximal AUC using NN with RFE was 0.74.Sixteen risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary decompression.We developed a web-based POPF prediction platform,and this application is freely available at http://gffzz52cab37b8d4e4d2ch060xq5ncc9b96qoo.ffgz.tsg.suse.edu.cn This study is the first to predict POPF with multiple risk factors using AI.This platform is reliable(AUC 0.74),so it could be used to select patients who need especially intense therapy and to preoperatively establish an effective treatment strategy. | In Woong Han Kyeongwon Cho Youngju Ryu Sang Hyun Shin Jin Seok Heo Dong Wook Choi Myung Jin Chung Oh Chul Kwon Baek Hwan Cho | 2020 | World Journal of Gastroenterology2020，26，30： | 12 |
| 2 | Effect of external beam radiotherapy on patency of uncovered metallic stents in patients with inoperable bile duct cancer显示文摘BACKGROUND: Although biliary decompression with metallic stenting is the preferred treatment for inoperable bile duct cancer(BDC), maintenance of patency is still unsatisfactory.We tried to assess the effectiveness and safety of external beam radiotherapy(EBRT) for prolonging stent patency in patients having uncovered metallic stents.METHOD: We retrospectively reviewed 50 patients who received endoscopic stenting, of whom 18 received EBRT(RT group) and 32 did not(non-RT group).RESULTS: No difference was found in baseline characteristics between the two groups. Although stent patency was longer in the RT group than that in the non-RT group(140.7±51.3 vs136.4±34.9 days, P=0.94), the difference was not statistically significant. There were a lower rate of stent occlusion(27.8% vs50.0% of patients, P=0.12) and a longer overall survival(420.1 ±73.2 vs 269.1±41.7 days, P=0.11) in the RT group than in the non-RT group, and the difference again was not statistically significant. The development of adverse reactions did not differ(55.6% vs 53.1% of patients, P=0.91). There was no serious adverse reaction in both groups(P=0.99).CONCLUSIONS: EBRT did not significantly improve stent patency in patients with inoperable BDC having uncovered metallic stents. However, EBRT was safe. Future trials withrefined protocols for better efficacy are expected. | Jun Kyu Lee Won Kwon Kwack Sang Hyub Lee Jin Hee Jung Jae Hyun Kwon In Woong Han Jin Ho Lee | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 3 |
| 3 | Second to fourth digit ratio: a predictor of adult penile ength显示文摘第二与雄激素受体(AR ) 的敏感为出生前的睾丸激素和 covaries 作为通常认为的 biomarker 被建议了到第四位比率(2D:4D ) 。出生前的睾丸激素和 AR 在阴茎生长起一个中央作用。在这研究,我们调查了在位比率和阴茎长度之间的关系。在一个单个第三级的学术中心为 urological 外科被就医的朝鲜的人在这被检查给了知情同意的 20 岁以上的学习,和 144 个人有希望地被注册。右边的秒位和第四位的长度被一个单个调查者在阴茎长度的测量以前测量。在麻醉下面,松驰、拉长的阴茎长度被另一个调查者测量没测量也不有任何东西关于位长度的信息。用线性回归模型的 Univariate 和 multivariate 分析证明那唯一的高度是为松驰的阴茎长度的一个重要预兆的因素(univariate 分析:r=0.185, P=0.026;multivariate 分析:r=0.172, P=0.038 ) 并且那唯一的位比率是为拉长的阴茎长度的一个重要预兆的因素(univariate analysis:r=− 0.216, P=0.009;multivariate 分析:r=− 0.201, P=0.024;拉长的阴茎 length=− 9.201 ×位比率 +20.577 ) 。把证据基于这,我们建议位比率能预言成年阴茎尺寸并且出生前的睾丸激素的效果可以部分地在成年阴茎长度解释差别。 | In Ho Choi Khae Hawn Kim Han Jung Sang Jin Yoon Soo Woong Kim Tae Beom Kim | 2011 | Asian Journal of Andrology2011，13，5： | 2 |
| 4 | Catheter Tract Recurrence After Percutaneous Biliary Drainage for Hilar Cholangiocarcinoma显示文摘 | Mee Joo Kang Yun-Suk Choi Jin-Young Jang In Woong Han Sun-Whe Kim | 2013 | World Journal of Surgery2013，，2： | 1 |
| 5 | Early versus delayed laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage显示文摘 | In Woong Han Jin-Young Jang Mee Joo Kang Kyoung Bun Lee Seung Eun Lee Sun-Whe Kim | 2012 | Journal of Hepato - Biliary - Pancreatic Sciences2012，，2： | 1 |
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