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| 1 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | Sodium inversion recovery MRI of the knee joint in vivo at 7T显示文摘 | Madelin G Lee JS Inati S et ai | 2010 | J Magn Reson2010，207，1： | 1 |
| 3 | A Muhiservice WLAN Using a Radio Resource Scheduler显示文摘 | INATY E | 2010 | European Transactions on Telecommunica- tions2010，21，1： | 1 |
| 4 | Differentiating BOLD and non -BOLD signals in fMRI time series using multi -echo EPI显示文摘 | Kundu P Inati SJ Evans JW | 2012 | Neuro- image2012，60，3： | 1 |
| 5 | Codedivision multiple access enabled dynamic bandwidth allocation(CDBA)scheme for EPON显示文摘 | Inaty E Raad R Fortier P | 2012 | Journal of Optical Communications and Networking2012，4，3： | 1 |
| 6 | Multirate optical fast frequency hopping CDMA system using power control显示文摘 | Inaty E Shalaby H M H Fortier P | 2002 | Journal of Lightwave Technology2002，20，2： | 1 |
| 7 | Code division multiple access enabled dynamic bandwidth allocation ( CDBA ) Scheme for EPON 显示文摘 | INATY E RAAD R FORTIER P | 2012 | Journal of Optical Communications and Networking2012，4，3： | 1 |
| 8 | Efficacy and tolerability of peginterferon alpha-2a with or without ribavirin in thalassemia major patients with chronic hepatitis C virus infection显示文摘 | Inati A Taher A Ghorra S | 2005 | Br J Hematol2005，130，4： | 1 |
| 9 | Functional connectivity:Integrating behavioral,diffusion tensor imaging,and functional magnetic resonance imaging data sets显示文摘 | Baird A.A Colvin M.K VanHorn J.D Inati S & Gazzaniga M.S | | 0，，： | 1 |
| 10 | Evidence for area CA1 as a match/mismatch detector:a high-resolution fMRI study of the human显示文摘 | Duncan K Ketz N Inati SJ | | 0，，3： | 1 |
| 11 | Evidence for area CA1 as a match/mismatch detector: a high-resolu- tion fMRI study of the human hippocampus显示文摘 | Duncan K Ketz N Inati S J Davachi L | 2012 | Hippo- campus2012，22，： | 1 |
| 12 | Imaging degeneration of the substantia nigra in Parkinson' s disease with inversion recovery MR1 显示文摘 | M inati L Grisoli M Carella F | 2007 | AJNR Am J Neuroradiology2007，28，： | 1 |
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